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D-AP5

Catalog No. T10930 CAS 79055-68-8

Synonyms: D-APV, D-2-Amino-5-phosphonovaleric acid

D-AP5 (D-APV) is a NMDA receptor antagonist.

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D-AP5, CAS 79055-68-8

Pack Size	Availability	Price/USD
1 mg	In stock	$ 30.00
2 mg	In stock	$ 40.00
5 mg	In stock	$ 64.00
10 mg	In stock	$ 113.00
25 mg	In stock	$ 239.00
50 mg	In stock	$ 477.00
1 mL * 10 mM (in DMSO)	In stock	$ 62.00

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Purity: 100%

Biological Description

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Description	D-AP5 (D-APV) is a NMDA receptor antagonist.
Targets&IC50	NMDA:1.4 μM(kd)
In vivo	D-AP5 is an NMDA receptor antagonist. Chronic intraventricular injection of D-AP5 can cause dose-dependent parallel damage to spatial learning and long-term enhancement (LTP) in vivo. When preventing spatial learning, the concentration of D-AP5 in the brain cannot cause any measurable sensorimotor disturbances. Compared with the test, D-AP5 infusion will cause a gradual decrease in swimming speed. D-AP5 causes sensorimotor disturbances in space tasks, but gradually deteriorates due to the inability of animals to learn. Rats treated with D-AP5 showed spatially dependent delay-dependent defects in the delayed matching placement protocol of the water maze.

Synonyms	D-APV, D-2-Amino-5-phosphonovaleric acid
Molecular Weight	197.13
Formula	C5H12NO5P
CAS No.	79055-68-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: < 1 mg/mL (insoluble)

H2O: 27.78 mg/mL (140.92 mM), Sonification is recommended.

References and Literature

1. Davis S, et al. The NMDA receptor antagonist D-2-amino-5-phosphonopentanoate (D-AP5) impairs spatial learning and LTP in vivo at intracerebral concentrations comparable to those that block LTP in vitro. J Neurosci. 1992 Jan;12(1):21-34. 2. Morris RG, et al. N-methyl-d-aspartate receptors, learning and memory: chronic intraventricular infusion of the NMDA receptor antagonist d-AP5 interacts directly with the neural mechanisms of spatial learning. Eur J Neurosci. 2013 Mar;37(5):700-17.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Anti-Neurodegenerative Disease Compound Library Anti-Alzheimer's Disease Compound Library Bioactive Compounds Library Max Bioactive Compound Library NO PAINS Compound Library Neurotransmitter Receptor Compound Library Neuronal Signaling Compound Library Anti-Cancer Compound Library Antidepressant Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Keywords

D-AP5 79055-68-8 Membrane transporter/Ion channel Neuroscience NMDAR iGluR inhibit D-AP-5 Ionotropic glutamate receptors DAP5 D-APV Inhibitor D AP5 D-2-Amino-5-phosphonovaleric acid inhibitor

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