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Cholic acid sodium

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Catalog No. T4537Cas No. 361-09-1
Alias SodiumCholate

Cholic acid sodium (SodiumCholate) exhibits a strong spermicidal and antiviral [anti-human immunodeficiency virus (HIV)-1] activity.

Cholic acid sodium
Other Forms of Cholic acid sodium:

Cholic acid sodium

🥰Excellent
Purity: 99.86%
Catalog No. T4537Alias SodiumCholateCas No. 361-09-1
Cholic acid sodium (SodiumCholate) exhibits a strong spermicidal and antiviral [anti-human immunodeficiency virus (HIV)-1] activity.
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1 g$29In Stock
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Purity:99.86%
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Product Introduction

Bioactivity
Description
Cholic acid sodium (SodiumCholate) exhibits a strong spermicidal and antiviral [anti-human immunodeficiency virus (HIV)-1] activity.
In vivo
Cholic acid (sodium cholate) exhibits a strong spermicidal and antiviral [anti-human immunodeficiency virus (HIV)-1] activity.?The same effects are observed for F-5 Gel, the active mixture of a new contraceptive sponge (Protectaid), which contains sodium cholate in association with low concentrations (0.5%) of nonoxynol-9 and benzalkonium chloride.?Both cholic acid and the F-5 Gel exert a dose-dependent, in-vitro inhibitory effect (i) on the activity of HIV-1 associated reverse transcriptase in an acellular system and (ii) on the potential of HIV-1 efficiently to infect human lymphocytes.
SynonymsSodiumCholate
Chemical Properties
Molecular Weight430.55
FormulaC24H39NaO5
Cas No.361-09-1
SmilesO[C@H]1[C@@]2([H])[C@@]3([H])[C@@]([C@@](CC3)([H])[C@H](C)CCC([O-])=O)([C@H](C[C@]2([H])[C@@]4([C@](C[C@@H](CC4)O)([H])C1)C)O)C.[Na+]
Relative Density.0.999 g/cm3 at 20.09℃
ColorWhite
AppearanceSolid
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
H2O: 62.5 mg/mL (145.16 mM), Sonication is recommended.
DMSO: 50 mg/mL (116.13 mM), Sonication is recommended.
Solution Preparation Table
DMSO/H2O
1mg5mg10mg50mg
1 mM2.3226 mL11.6131 mL23.2261 mL116.1305 mL
5 mM0.4645 mL2.3226 mL4.6452 mL23.2261 mL
10 mM0.2323 mL1.1613 mL2.3226 mL11.6131 mL
20 mM0.1161 mL0.5807 mL1.1613 mL5.8065 mL
50 mM0.0465 mL0.2323 mL0.4645 mL2.3226 mL
100 mM0.0232 mL0.1161 mL0.2323 mL1.1613 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
% DMSO
%
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% Saline/PBS/ddH2O

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

taurineInhibitorinhibitHIVProteaseHIV ProteaseHIVHepG2glycineEndogenousMetaboliteEndogenous MetaboliteCholic acid sodiumCholic acidcholesterol excretion
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