Home Tools

Chalcone

Catalog No. T2S0961 CAS 94-41-7

Synonyms: benzylideneacetophenone, phenyl styryl ketone, Cinnamophenone, benzalacetophenone, β-phenylacrylophenone

Chalcone (Cinnamophenone) is an aromatic ketone that forms the central core for a variety of important biological compounds, which are known collectively as chalcones.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Chalcone, CAS 94-41-7

Pack Size	Availability	Price/USD
100 mg	In stock	$ 41.00
200 mg	In stock	$ 64.00
500 mg	In stock	$ 116.00

Bulk Inquiry

Select Batch

Purity: 97.89%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Chalcone (Cinnamophenone) is an aromatic ketone that forms the central core for a variety of important biological compounds, which are known collectively as chalcones.
Targets&IC50	EGFR:10 µM (in A431 cells)
In vitro	AG99, a potent inhibitor of EGFR, was shown to inhibit the appearance of pp145 to some extent. AG99 promotes cell death of normal and cancer cells via activation of caspase-like proteases in vitro [2].
Cell Research	Human bladder carcinoma cell line 5637 was maintained in RPMI1640 medium supplemented with 10% fetal calf serum (FCS), 1 mM L-glutamine, and antibiotics. Cells were grown at 37°C in a humidified 5% CO2 atmosphere. For all experiments, confluent cells were trypsinized, and aliquots of single-cell suspension were re-seeded at 0.5×10^6 cells/dish (100-mm diameter) or 0.1×106 cells/dish (60-mm diameter) and cultured in poly-L-lysine-coated new culture dishes containing normal culture media for 24-48 hours. After the normal growth treatment, cells were treated under several different conditions as specified in the text. When cell number and cell viability were determined, both attached cells and unattached cells were collected by trypsinization and sedimentation of the culture media, respectively, and combined in one tube. The cells were washed twice with phosphate-buffered saline (PBS) and aliquots of the cells were stained with Trypan Blue solution. After the staining, cells were mounted in a hemocytometer for microscopic observation. Total cell number was determined by counting more than 300 cells per condition. The percentage of Trypan-Blue-stained cells (versus total cell number) was determined by calculation of data obtained with three independent counting of more than 100 cells. When nuclear morphology was evaluated, cells were grown and treated in glass-bottom dishes. After treatment, the cells were washed three times with PBS, fixed with 4% paraformaldehyde in PBS for 10 minutes, permeabilized with 0.2% Triton X-100 in PBS for 2 minutes and blocked with 3% BSA in PBS for 1 hour. Cells were then treated with propidium iodide at 2 μg/ml in PBS for 1 hour. After washing with PBS (three times 5 minutes), samples were mounted in PBS containing 50 mg/ml 1,4-diazabicyclo[2,2,2]octane and 90% glycerol and subjected to confocal microscopic observation. The fluorescence was detected at 543 nm argon excitation using optics of a 590 nm long-pass barrier filter.The fluorescent images were recorded and reconstituted with the use of software Adobe Photoshop CS [2].

Synonyms	benzylideneacetophenone, phenyl styryl ketone, Cinnamophenone, benzalacetophenone, β-phenylacrylophenone
Molecular Weight	208.26
Formula	C15H12O
CAS No.	94-41-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 201.7 mM

H2O: 4.8 mM

References and Literature

1. Hsu YL, et al. Chalcone inhibits the proliferation of human breast cancer cell by blocking cell cycle progression and inducing apoptosis. Food Chem Toxicol. 2006 May;44(5):704-13.

Related compound libraries

This product is contained In the following compound libraries：

Kinase Inhibitor Library Antiparasitic Natural Product Library Anti-Cancer Active Compound Library Membrane Protein-targeted Compound Library Anti-Parasitic Compound Library Tobacco Monomer Library Tyrosine Kinase Inhibitor Library Tibetan medicine Compound Library Angiogenesis related Compound Library RO5 Drug-like Natural Product Library

Related Products

Related compounds with same targets

Khellin Olmutinib Daphnetin PP2 Zorifertinib AZD3759 hydrochloride Depatuxizumab ALK/EGFR-IN-1

Dose Conversion

You can also refer to dose conversion for different animals. More

In vivo Formulation Calculator (Clear solution)

Step One: Enter information below

Dosage

mg/kg

Average weight of animals

Dosing volume per animal

Number of animals

Step Two: Enter the in vivo formulation

% DMSO+

% +

% Tween 80+

% ddH₂O

%DMSO+

Calculate Reset

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

Calculator

Molarity Calculator

Dilution Calculator

Reconstitution Calculation

Molecular Weight Calculator

Mass

Concentration

Volume

Molecular Weight

Molarity Calculator allows you to calculate the

Mass of a compound required to prepare a solution of known volume and concentration
Volume of solution required to dissolve a compound of known mass to a desired concentration
Concentration of a solution resulting from a known mass of compound in a specific volume

See Example

An example of a molarity calculation using the molarity calculator
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
Enter 197.13 into the Molecular Weight (MW) box
Enter 10 into the Concentration box and select the correct unit (millimolar)
Enter 10 into the Volume box and select the correct unit (milliliter)
Press calculate
The answer of 19.713 mg appears in the Mass box

Concentration (Start)

Volume (Start)

Concentration (End)

Volume (End)

Calculator the dilution required to prepare a stock solution

Calculate the dilution required to prepare a stock solution
The dilution calculator is a useful tool which allows you to calculate how to dilute a stock solution of known concentration. Enter C1, C2 & V2 to calculate V1.

See Example

An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
Enter 10 into the Concentration (start) box and select the correct unit (millimolar)
Enter 50 into the Concentration (final) box and select the correct unit (micromolar)
Enter 20 into the Volume (final) box and select the correct unit (milliliter)
Press calculate
The answer of 100 microliter (0.1 ml) appears in the Volume (start) box

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

Calculate the volume of solvent required to reconstitute your vial.

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial.
Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Molecule Formula

Molecular Weight g/mol

Enter the chemical formula of a compound to calculate its molar mass and elemental composition

Tip: Chemical formula is case sensitive: C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:
To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.
Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed n the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

bottom

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Chalcone 94-41-7 Angiogenesis JAK/STAT signaling Microbiology/Virology Tyrosine Kinase/Adaptors EGFR Antibacterial anti-parasitic anti-inflammatory b-phenylacrylophenone beta-phenylacrylophenone benzylideneacetophenone phenyl styryl ketone antibacterial Cinnamophenone Inhibitor Bacterial antioxidative benzalacetophenone β-phenylacrylophenone anticancer inhibit inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.