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Calmidazolium chloride

Catalog No. T10667   CAS 57265-65-3
Synonyms: R 24571

Calmidazolium chloride (R 24571) is a calmodulin (CaMK) antagonist (Kd = 3 nM), antagonizing CaM-dependent phosphodiesterase(IC50 = 0.15 μM) and calmodulin-induced activation of erythrocyte Ca2+-transporting ATPase(IC50 = 0.35 μM). Calmidazolium chloride also induces apoptosis in certain cancer cell lines.

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Calmidazolium chloride Chemical Structure
Calmidazolium chloride, CAS 57265-65-3
Pack Size Availability Price/USD Quantity
5 mg In stock $ 57.00
10 mg In stock $ 89.00
25 mg In stock $ 148.00
50 mg In stock $ 226.00
100 mg In stock $ 337.00
200 mg In stock $ 491.00
1 mL * 10 mM (in DMSO) In stock $ 87.00
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Purity: 98.06%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Calmidazolium chloride (R 24571) is a calmodulin (CaMK) antagonist (Kd = 3 nM), antagonizing CaM-dependent phosphodiesterase(IC50 = 0.15 μM) and calmodulin-induced activation of erythrocyte Ca2+-transporting ATPase(IC50 = 0.35 μM). Calmidazolium chloride also induces apoptosis in certain cancer cell lines.
Targets&IC50 calmodulin-induced activation of erythrocyte Ca2+-transporting ATPase:0.35 μM, calmodulin:8.18 μM(mouse F9 ECCs), calmodulin:3 nM(kd), calmodulin:12.69 μM(mouse E14 ESCs), CaM-dependent phosphodiesterase:0.15 μM
In vitro Calmidazolium chloride also induces apoptosis in certain cancer cell lines. Calmidazolium chloride (3, 5, 7, 10 μM, 30 minutes-24 hours) inhibits the growth of mouse F9 ECCs [2].
Synonyms R 24571
Molecular Weight 687.7
Formula C31H23Cl7N2O
CAS No. 57265-65-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 100 mg/mL (145.41 mM)

TargetMolReferences and Literature

1. Gietzen K, et al. Comparison of the calmodulin antagonists compound 48/80 and calmidazolium. Biochem J. 1983 Dec 15;216(3):611-6. 2. Lee J, et al. Calmidazolium chloride inhibits growth of murine embryonal carcinoma cells, a model of cancer stem-like cells. Toxicol In Vitro. 2016 Sep;35:86-92. 3. Budu A, et al. Calmidazolium evokes high calcium fluctuations in Plasmodium falciparum. Cell Signal. 2016 Mar;28(3):125-135.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Active Compound Library Neuronal Signaling Compound Library Inhibitor Library Kinase Inhibitor Library Anti-Cancer Compound Library Bioactive Compounds Library Max Bioactive Compound Library

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Keywords

Calmidazolium chloride 57265-65-3 Autophagy Neuroscience CaMK R-24571 Calmidazolium Inhibitor inhibit R 24571 Calmodulin-dependent protein kinases Calmodulin-dependent kinases R24571 Calmidazolium Chloride inhibitor

 

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