Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CGP 37849 is a competitive orally active N-methyl-D-aspartate (NMDA) receptor antagonist ((Ki = 35 nM)) with potency.CGP 37849 is an anticonvulsant in rodents and also has antidepressant and anxiolytic properties.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 163.00 | |
5 mg | In stock | $ 372.00 | |
10 mg | In stock | $ 556.00 | |
25 mg | In stock | $ 896.00 | |
50 mg | In stock | $ 1,220.00 | |
100 mg | In stock | $ 1,650.00 |
Description | CGP 37849 is a competitive orally active N-methyl-D-aspartate (NMDA) receptor antagonist ((Ki = 35 nM)) with potency.CGP 37849 is an anticonvulsant in rodents and also has antidepressant and anxiolytic properties. |
Targets&IC50 | Seizures:21 mg/kg(ED50), l-[3H]-glutamate:220 nM(Ki), [3H]-(±)-3-(2-carboxypiperazin-4-yl)propyl-1-phosphonate (CPP):35 nM(Ki) |
In vitro | Within the hippocampal slice in vitro, CGP 37849 demonstrates reversible and selective antagonism against NMDA-induced increases in the firing rate of CA1 pyramidal cells. In the presence of a low Mg2+ level medium, concentrations of CGP 37849 up to 10 μM effectively inhibit burst firing evoked in CA1 neurons by stimulating Schaffer collateral-commissural fibers, while leaving the magnitude of the initial population spike unaffected.[1] |
In vivo |
In vivo, oral administration to rats of CGP 37849 selectively blocks firing in hippocampal neurons induced by ionophoretically-applied NMDA, without affecting the responses to quisqualate or kainate.[1]
Oral administration to mice of CGP 37849 suppresses maximal electroshock-induced seizures in mice with an ED50 of 21 mg/kg.[1] |
Synonyms | CGP-37849, CGP37849 |
Molecular Weight | 209.14 |
Formula | C6H12NO5P |
CAS No. | 127910-31-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 90.0 mg/mL (430.3 mM)
DMSO: Soluble
You can also refer to dose conversion for different animals. More
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CGP 37849 127910-31-0 Membrane transporter/Ion channel Neuroscience NMDAR iGluR CGP-37849 CGP37849 inhibitor inhibit