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Bemnifosbuvir hemisulfate

Catalog No. T9331 CAS 2241337-84-6

Synonyms: AT-527

Bemnifosbuvir hemisulfate (AT-527) is a potent inhibitor of HCV virus replication.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Bemnifosbuvir hemisulfate Chemical Structure

Bemnifosbuvir hemisulfate, CAS 2241337-84-6

Pack Size	Availability	Price/USD
1 mg	In stock	$ 115.00
5 mg	In stock	$ 247.00
10 mg	In stock	$ 413.00
25 mg	In stock	$ 692.00
50 mg	In stock	$ 985.00
100 mg	In stock	$ 1,330.00

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Purity: 99.74%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Bemnifosbuvir hemisulfate (AT-527) is a potent inhibitor of HCV virus replication.
Targets&IC50	SARS-CoV-2:0.47μM(EC90), HCV:5-28nM
In vitro	The potent in vitro activity of AT-511, the free base of bemnifosbuvir hemisulfate, against several coronaviruses, including SARS-CoV-2. In normal human airway epithelial cells, the concentration of AT-511 required to inhibit replication of SARS-CoV-2 by 90% (EC90) was 0.47?μM, very similar to its EC90 against human coronavirus (HCoV)-229E, HCoV-OC43, and SARS-CoV in Huh-7 cells[1].
In vivo	When given orally to rats and monkeys, bemnifosbuvir hemisulfate preferentially delivered high levels of AT-9010 in the liver in vivo.These favorable preclinical attributes support bemnifosbuvir hemisulfate may increase SVR rates[2].

Synonyms	AT-527
Molecular Weight	1261.15
Formula	C48H68F2N14O18P2S
CAS No.	2241337-84-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 170 mg/mL (269.60 mM), Sonication is recommended.

References and Literature

1. Good S S , Westover J , Jung K H , et al. AT-527, a Double Prodrug of a Guanosine Nucleotide Analog, Is a Potent Inhibitor of SARS-CoV-2 In Vitro and a Promising Oral Antiviral for Treatment of COVID-19[J]. Antimicrobial agents and chemotherapy, 65(4):e02479-20. 2. Good S S , Moussa A , Zhou X J , et al. Preclinical evaluation of AT-527, a novel guanosine nucleotide prodrug with potent, pan-genotypic activity against hepatitis C virus[J]. PLoS ONE, 2020, 15(1):e0227104-.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Infection Compound Library NO PAINS Compound Library Covalent Inhibitor Library Anti-Viral Compound Library Clinical Compound Library Bioactive Compound Library Orally Active Compound Library Bioactive Compounds Library Max Nucleotide Compound Library Drug Repurposing Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Bemnifosbuvir hemisulfate 2241337-84-6 Microbiology/Virology Proteases/Proteasome HCV Protease SARS-CoV Inhibitor antiviral phosphoramidate HCV AT-527 nucleotide Bemnifosbuvir pangenotypic AT 527 Bemnifosbuvir Hemisulfate guanosine SARS coronavirus AT527 Hepatitis C virus inhibit inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.