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Bacoside A3

Catalog No. TN1425 CAS 157408-08-7

Bacoside A3 is one of the components of Bacopa monnieri (L.) Wettst. bacoside A with antioxidant potential. Bacoside A3 shows comparatively higher neuroprotective response analysed as higher cell viability and decreased intracellular ROS.

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Bacoside A3, CAS 157408-08-7

Pack Size	Availability	Price/USD
1 mg	In stock	$ 68.00
5 mg	In stock	$ 160.00
10 mg	In stock	$ 235.00
1 mL * 10 mM (in DMSO)	In stock	$ 268.00

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Description	Bacoside A3 is one of the components of Bacopa monnieri (L.) Wettst. bacoside A with antioxidant potential. Bacoside A3 shows comparatively higher neuroprotective response analysed as higher cell viability and decreased intracellular ROS.
In vitro	The cytoprotective effects of individual bacoside A components were evaluated towards oxidative stressed neuronal cells. Bacoside A was screened for neuronal cell viability (MTT assay) and change in intracellular reactive oxygen species (ROS), anti-apoptotic properties and mitochondrial membrane potential (MMP) using fluorescence microscopy. Different bacoside A components showed decrease in N2a cell viability below 100 (%) after bacoside A concentration of 0.4 mg/ml. Further, cytoprotective effect of optimized dose of bacoside A was analysed for alleviating oxidative stressed, apoptosis and MMP in H2 O2 stressed neuronal cells. Results showed increase in MMP, and decrease in apoptotic induction, without much change in nuclear integrity in stressed neuronal cells. Results showed Bacoside A3 and bacopaside II have comparatively higher cytoprotective ability whilst isomer of bacopasponin C, bacopasaponin C and mixture showed comparatively less response[1]
Source	Natural Products > Scrophulariaceae > Bacopa

Molecular Weight	929.1
Formula	C47H76O18
CAS No.	157408-08-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 60 mg/mL (64.58 mM)

References and Literature

1. Bhardwaj P, Jain CK, Mathur A. Comparative evaluation of four triterpenoid glycoside saponins of bacoside A in alleviating sub-cellular oxidative stress of N2a neuroblastoma cells. J Pharm Pharmacol. 2018 Nov;70(11):1531-1540. 2. Vini C Sekhar, et al. Insights Into the Molecular Aspects of Neuroprotective Bacoside A and Bacopaside I. Curr Neuropharmacol. 2019;17(5):438-446.

Related compound libraries

This product is contained In the following compound libraries：

Membrane Protein-targeted Compound Library Natural Product Library for HTS Cuproptosis Compound Library Neuronal Signaling Compound Library

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Keywords

Bacoside A3 157408-08-7 Immunology/Inflammation Membrane transporter/Ion channel Neuroscience ATPase ROS P-gp Inhibitor Bacoside A-3 Bacoside A 3 inhibit inhibitor

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