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Ciclopirox

Catalog No. T1482   CAS 29342-05-0
Synonyms: HOE296b

Ciclopirox (HOE296b) exerts its action by binding to and chelating trivalent cations, such as Fe3+ and Al3+, thereby inhibiting the availability of essential co-factors for enzymes. Ciclopirox is a synthetic, broad-spectrum antifungal agent with additional antibacterial and anti-inflammatory activities. This may lead to a loss of activity of enzymes that are essential for cellular metabolism, the organization of cell wall structure and other crucial cell functions. In addition, ciclopirox exerts its anti-inflammatory activity by inhibiting 5-lipoxygenase and cyclooxygenase (COX).

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Ciclopirox Chemical Structure
Ciclopirox, CAS 29342-05-0
Pack Size Availability Price/USD Quantity
25 mg In stock $ 30.00
50 mg In stock $ 43.00
100 mg In stock $ 61.00
200 mg In stock $ 89.00
500 mg In stock $ 148.00
1 mL * 10 mM (in DMSO) In stock $ 48.00
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Purity: 99.41%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Ciclopirox (HOE296b) exerts its action by binding to and chelating trivalent cations, such as Fe3+ and Al3+, thereby inhibiting the availability of essential co-factors for enzymes. Ciclopirox is a synthetic, broad-spectrum antifungal agent with additional antibacterial and anti-inflammatory activities. This may lead to a loss of activity of enzymes that are essential for cellular metabolism, the organization of cell wall structure and other crucial cell functions. In addition, ciclopirox exerts its anti-inflammatory activity by inhibiting 5-lipoxygenase and cyclooxygenase (COX).
In vivo Ciclopirox induces the activity of HIF-1-mediated reporter genes and the expression of endogenous HIF-1 target genes, including increased levels of mRNA expression, transcription, and vascular endothelial growth factor protein. It exerts a dose-dependent inhibitory effect on the growth of Candida albicans yeast and filamentous cells. Ciclopirox prevents mitochondrial damage induced by H2O2 by maintaining mitochondrial transmembrane potential. In adenocarcinoma SK-HEP-1 cells, Ciclopirox decreases MTT reduction (a marker of mitochondrial function) and completely blocks the release of lactate dehydrogenase (a marker of cell death) stimulated by hydrogen peroxide. In astrocytes treated with SIN-1 under glucose deprivation, Ciclopirox increases and maintains high levels of MTP, also preventing the depletion of adenosine triphosphate. Furthermore, Ciclopirox effectively inhibits the opening of mitochondrial permeability transition pores induced by hydrogen peroxide and protects astrocytes from peroxynitrite toxicity by mitigating mitochondrial dysfunction caused by nitrite.
Synonyms HOE296b
Molecular Weight 207.27
Formula C12H17NO2
CAS No. 29342-05-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 20.7 mg/mL (100 mM)

DMSO: 50 mg/mL (241.23 mM)

TargetMolReferences and Literature

1. Linden T, et al. FASEB J,2003, 17(6), 761-763. 2. Sigle HC, et al. J Antimicrob Chemother,2005, 55(5), 663-673. 3. Lee SJ, et al. Br J Pharmacol,2005, 145(4), 469-476. 4. Choi JJ, et al. Neuropharmacology,2002, 43(3), 408-417. 5. Braga PC, et al. Arzneimittelforschung,1992, 42(11), 1368-1371. 6. Huang Y, Su R, Sheng Y, et al. Small-molecule targeting of oncogenic FTO demethylase in acute myeloid leukemia[J]. Cancer Cell. 2019, 35(4): 677-691. e10.

TargetMolCitations

1. Huang Y, Su R, Sheng Y, et al. Small-molecule targeting of oncogenic FTO demethylase in acute myeloid leukemia. Cancer Cell. 2019, 35(4): 677-691. e10.

Related compound libraries

This product is contained In the following compound libraries:
Membrane Protein-targeted Compound Library Anti-Cancer Clinical Compound Library Inhibitor Library Anti-Cancer Approved Drug Library Drug Repurposing Compound Library Anti-Cancer Drug Library Bioactive Compound Library Drug-Fragment Library Approved Drug Library Human Metabolite Library

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Keywords

Ciclopirox 29342-05-0 Apoptosis Autophagy Membrane transporter/Ion channel Microbiology/Virology Ferroptosis ATPase Antibacterial Antifungal Fungal inhibit Inhibitor HOE296b Bacterial inhibitor

 

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