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Amuvatinib

Catalog No. T2516 CAS 850879-09-3

Synonyms: MP470, HPK 56

Amuvatinib (MP470) is an orally bioavailable synthetic carbothioamide with potential antineoplastic activity.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Amuvatinib, CAS 850879-09-3

Pack Size	Availability	Price/USD
1 mg	In stock	$ 44.00
2 mg	In stock	$ 62.00
5 mg	In stock	$ 93.00
10 mg	In stock	$ 150.00
25 mg	In stock	$ 275.00
50 mg	In stock	$ 441.00
100 mg	In stock	$ 556.00
1 mL * 10 mM (in DMSO)	In stock	$ 101.00

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Purity: 99.54%

Purity: 99.38%

Purity: 98.48%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Amuvatinib (MP470) is an orally bioavailable synthetic carbothioamide with potential antineoplastic activity.
Targets&IC50	c-Kit (D816H):10 nM, PDGFRα (V561D):40 nM, FLT3 (D835Y):81 nM
Kinase Assay	Kinase inhibition assay of c-Kit and PDGFRα: For the testing of inhibitory activity against c-Kit and PDGFRα, enzymes are incubated with varying concentrations of MP-470 and radiolabeled γ-32P-ATP. After 30 min, the reaction mixtures are electrophoresed on an acrylamide gel and autophosphorylation, quantitated by the amount of radioactivity incorporated into the enzyme, is assayed.
Cell Research	Cells are plated at a density of 2 × 103 to 1 × 104 cells per well in 100 μL medium on day 0 in 96-well Falcon microtitier plates. On day 1, ten μL of serial dilutions of MP-470 are added to the plates in quadruplicates. After incubation for 4 days, the cells are fixed with 10% Trichloroacetic acid solution. Subsequently, they are labeled with 0.04% Sulforhodamine B (SRB) in 1% acetic acid. After multiple washes to remove the excess dye, 100 μL of 50 mM Tris solution is added to each well in order to dissolve the dye. The absorbance of each well is read on a plate reader at 570 nm. Date are expressed as the percentage of survival of control calculated from the absorbance corrected for background absorbance. The surviving percent of cells is determined by dividing the mean absorbance values of the monoclonal antibody by mean absorbance values of the control and multiplying by 100.(Only for Reference)

Synonyms	MP470, HPK 56
Molecular Weight	447.51
Formula	C23H21N5O3S
CAS No.	850879-09-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 30 mg/mL (67 mM)

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

References and Literature

2. Hurley LH, et al. World Patent, WO/2005/037825. 3. Mahadevan D, et al. Oncogene, 2007, 26(27), 3909-3919. 4. Qi W, et al. BMC Cancer, 2009, 9, 142. 5. Welsh JW, et al. Radiat Oncol, 2009, 4, 69. 6. Han H W, Hahn S, Jeong H Y, et al. LINCS L1000 dataset-based repositioning of CGP-60474 as a highly potent anti-endotoxemic agent[J]. Scientific reports. 2018 Oct 8;8(1):14969.

Citations

1. Han H W, Hahn S, Jeong H Y, et al. LINCS L1000 dataset-based repositioning of CGP-60474 as a highly potent anti-endotoxemic agent. Scientific Reports. 2018 Oct 8;8(1):14969

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Anti-Cancer Drug Library Anti-Cancer Clinical Compound Library Drug Repurposing Compound Library Anti-Cancer Active Compound Library Tyrosine Kinase Inhibitor Library Human Metabolite Library Clinical Compound Library Reprogramming Compound Library Angiogenesis related Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Amuvatinib 850879-09-3 Angiogenesis Apoptosis Cell Cycle/Checkpoint DNA Damage/DNA Repair Tyrosine Kinase/Adaptors DNA/RNA Synthesis c-Met/HGFR c-RET FLT PDGFR c-Kit HPK56 MP 470 MP-470 HPK-56 Fms like tyrosine kinase 3 Cluster of differentiation antigen 135 RET FLT3 CD117 CD135 Platelet-derived growth factor receptor SCFR MP470 Inhibitor RAD51 HPK 56 inhibit inhibitor

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