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ASP3026

Catalog No. T1962 CAS 1097917-15-1

Synonyms: ASP 3026

ASP3026 has been used in trials studying the treatment of Solid Tumor, B-Cell Lymphoma, Advanced Malignancies, Positive for Anaplastic Lymphoma Kinase, and Positive for Proto-Oncogene Tyrosine-Protein Kinase ROS.

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ASP3026, CAS 1097917-15-1

Pack Size	Availability	Price/USD
2 mg	In stock	$ 35.00
5 mg	In stock	$ 54.00
10 mg	In stock	$ 79.00
25 mg	In stock	$ 134.00
50 mg	In stock	$ 198.00
100 mg	In stock	$ 328.00
1 mL * 10 mM (in DMSO)	In stock	$ 123.00

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Purity: 98.78%

Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	ASP3026 has been used in trials studying the treatment of Solid Tumor, B-Cell Lymphoma, Advanced Malignancies, Positive for Anaplastic Lymphoma Kinase, and Positive for Proto-Oncogene Tyrosine-Protein Kinase ROS.
Targets&IC50	ALK:3.5 nM
In vitro	Mice harboring subcutaneous NCI-H2228 tumor xenografts were treated twice daily with the oral administration of ASP3026 for 14 days, which induced a dose-dependent antitumor effect, starting at 1 mg/kg and showing a pronounced reduction at 10, 30, and 100 mg/kg.
In vivo	ASP3026 inhibits the growth of the NCI-H2228 human NSCLC tumor cell line, which endogenously expresses the EML4-ALK variant 3, with an IC50 value of 64.8 nM. ASP3026 demonstrates enhanced selectivity in inhibiting ALK activity in tyrosine kinases compared to PF02341066.
Kinase Assay	Recombinant truncated FLAG-tagged mTOR expressed in HEK 293 cells is used in biochemical assays, together with a biotinylated p70S6K peptide substrate. Streptavidin donor and protein A acceptor beads are used to assemble the capture complex for generation of the assay signal. The activity of the lipid kinases, PI3K alpha, beta, delta, and gamma are measured using recombinant proteins and the lipid PIP2 as substrate. Assays for ATM and DNA-PK activity are performed. The mTOR cellular activity is measured in MDAMB468 cells, using an Acumen laser scanning cytometer to analyze the levels of phosphorylation of S6 (Ser235/236) and AKT (Ser473)[1].

Synonyms	ASP 3026
Molecular Weight	580.74
Formula	C29H40N8O3S
CAS No.	1097917-15-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 11.6 mg/mL (20 mM)

References and Literature

1. Sadao Kuromitsu, et al. AACR 102nd Annual Meeting, 2011.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Anti-Cancer Drug Library Anti-Cancer Clinical Compound Library Kinase Inhibitor Library Anti-Cancer Active Compound Library Drug Repurposing Compound Library Tyrosine Kinase Inhibitor Library Clinical Compound Library Angiogenesis related Compound Library Apoptosis Compound Library

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Keywords

ASP3026 1097917-15-1 Angiogenesis Apoptosis Tyrosine Kinase/Adaptors ALK inhibit ALK tyrosine kinase receptor Anaplastic lymphoma kinase (ALK) Inhibitor ASP-3026 Cluster of differentiation 246 ASP 3026 Anaplastic lymphoma kinase CD246 inhibitor

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