Powder: -20°C for 3 years | In solvent: -80°C for 1 year
ADH-503 (GB1275) is a potent agonist of the integrin CD11b to mitigate myeloid cell immunosuppression.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 48.00 | |
10 mg | In stock | $ 77.00 | |
25 mg | In stock | $ 129.00 | |
50 mg | In stock | $ 207.00 | |
100 mg | In stock | $ 288.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 54.00 |
Description | ADH-503 (GB1275) is a potent agonist of the integrin CD11b to mitigate myeloid cell immunosuppression. |
In vitro | The partial activation of CD11b by a small-molecule agonist (ADH-503) leads to the repolarization of tumor-associated macrophages, reduction in the number of tumor-infiltrating immunosuppressive myeloid cells, and enhanced dendritic cell responses.?These actions, in turn, improve antitumor T cell immunity and render checkpoint inhibitors effective in previously unresponsive PDAC models.?These data demonstrate that molecular agonism of CD11b reprograms immunosuppressive myeloid cell responses and potentially bypasses the limitations of current clinical strategies to overcome resistance to immunotherapy. |
In vivo | ADH-503 had the mean half-life of 4.68 and 3.95 hours, a maximum concentration of 1716 and 2594 ng/mL and AUC0-t in the plasma of 6950 and 13962 ng.h/mL at 30 and 100 mg/kg dosing, respectively. |
Animal Research | Animal Model:Male rats.Dosage:30,100 mg/kg (Pharmacokinetic Analysis). Administration:Oral gavage twice a day; on days 1 and 5 |
Synonyms | GB1275 |
Molecular Weight | 524.7 |
Formula | C27H28N2O5S2 |
CAS No. | 2055362-74-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 5.25 mg/mL (10 mM)
You can also refer to dose conversion for different animals. More
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ADH-503 2055362-74-6 Immunology/Inflammation Complement System GB1275 tumor-infiltrating ADH 503 CD11b GB 1275 Inhibitor tumorassociated dendritic immunosuppressive ADH503 macrophages repolarization allosteric inhibit orally GB-1275 inhibitor