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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
TP1474 | LXW7 | Integrin | |
LXW7 is an octamer disulfide cyclic peptide and αvβ3 integrin ligand, acts as a potent and specific endothelial progenitor cells (EPCs) and endothelial cells (ECs) targeting ligand. LXW7 is a disulfide cyclic octa-pepti... | |||
T6812L | Cyclo(-RGDfK) TFA | Integrin | |
Cyclo(-RGDfK) is a selective αvβ3 integrin inhibitor(IC50 : 0.94 nM). | |||
T6812 | Cyclo(-RGDfK) | Cyclo (-RGDfK) | Integrin |
Cyclo(-RGDfK) (Cyclo (-RGDfK)) is an effective and specific αvβ3 integrin inhibitor. | |||
TP1879L1 | P11 acetate | Integrin | |
P11 acetate is an integrin αvβ3-vitronectin interaction antagonist(IC50 = 2.74 nM). | |||
T6813 | Cyclo(RGDyK) trifluoroacetate | Cyclo(RGDyK) | Integrin |
Cyclo(RGDyK) trifluoroacetate is a potent and selective αVβ3 integrin inhibitor with IC50 of 20 nM. | |||
T6657 | SB273005 | Integrin | |
SB273005 is a potent integrin inhibitor with Ki of 1.2 nM and 0.3 nM for αvβ3 receptor and αvβ5 receptor, respectively. | |||
T2494 | Cilengitide | EMD 121974 | Integrin , Autophagy |
Cilengitide (EMD 121974) is a potent integrin inhibitor for the αvβ3/5 receptor (IC50: 4.1/79 nM, in cell-free assays); ~10-fold selectivity against gpIIbIIIa. | |||
TQ0250 | CWHM-12 | Integrin | |
CWHM-12 is a potent inhibitor of αV integrins (IC50s of 0.2/0.8/1.5/1.8 nM for αvβ8/αvβ3/αvβ6/αvβ1). | |||
T36715 | Tetrac | Tetraiodothyroacetic acid,3,3',5,5'-Tetraiodothyroacetic acid | Apoptosis , EGFR |
Tetrac (Tetraiodothyroacetic acid) is a derivative of L-thyroxine (T4), a thyroxine integrin receptor antagonist.Tetrac induces antiproliferation by blocking EGFR-mediated cell signaling in colorectal cancer cells.Tetrac... | |||
TP2148 | LXW7 TFA (1313004-77-1 free base) | LXW7 TFA | Integrin |
LXW7 TFA, a cyclic peptide containing Arg-Gly-Asp (RGD), is an integrin αvβ3 inhibitor with an anti-inflammatory effect. LXW7 has a high binding affinity to αvβ3 integrin (IC50: 0.68 μM). It increases the phosphorylation... | |||
T16085 | MK-0429 | L-000845704 | Others |
MK-0429 is an orally active, selective, and nonpeptide antagonist of αvβ3 integrin (IC50: 80 nM). | |||
T6806 | Cilengitide TFA | Integrin , Autophagy | |
Cilengitide is a potent integrin inhibitor for αvβ3 receptor and αvβ5 receptor with IC50 of 4.1 nM and 79 nM in cell-free assays, respectively; ~10-fold selectivity against gpIIbIIIa. Phase 2. | |||
TP1459L | Gly-Arg-Gly-Asp-Ser acetate(96426-21-0 free base) | Integrin | |
Gly-Arg-Gly-Asp-Ser (GRGDS) acetate is a cell binding protein domain derived from the cell-binding region of fibronectin. | |||
T11663 | Integrin-IN-2 | Others | |
Integrin-IN-2 is an orally bioavailable pan αv integrin inhibitor.Integrin-IN-2 can increases the αvβ6, αvβ3, αvβ5 and αvβ8 binding affinities with pIC50 values of 7.8, 8.4, 8.4 and 7.4, respectively. | |||
TP2390 | Maraciclatide | NC-100692,NC 100692,NC100692 | |
Maraciclatide is a radiopharmaceutical targeting αvβ3 integrin. | |||
T16851 | SB-267268 | Others | |
SB-267268 inhibits human and mouse αvβ3 (IC50s: 0.68 and 0.29 nM, respectively). SB-267268 is a selective and nonpeptidic alpha(v)beta3 and alpha(v)beta5 integrins antagonist (Kis: 0.9, 0.5 and 0.7 nM for human αvβ3, mon... | |||
T8726 | Cyclo(RGDyK) | Integrin | |
Cyclo(RGDyK) is a potent and selective αVβ3 integrin inhibitor with IC50 of 20 nM. | |||
T69460 | TSRI265 | ||
TSRI265 is a novel αvβ3 ligand, disrupting the integrin-MMP2 interaction and showing antiangiogenic activit, inhibiting angiogenesis and tumor growth in vivo. | |||
T15584 | Integrin Antagonists 27 | Others | |
Integrin Antagonists 27 is a small molecule integrin αvβ3 antagonist. It has a binding affinity of 18 nM and as a novel anticancer agent. | |||
TP1879 | HSDVHK-NH2 | P11 | |
Potent antagonist of the integrin αvβ3-vitronectin interaction (IC50 = 25.72 nM). Blocks proliferation and induces apoptosis in HUVECs; antiangiogenic. |