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P11 acetate

Catalog No. TP1879L1   CAS TP1879L1

P11 acetate is an integrin αvβ3-vitronectin interaction antagonist(IC50 = 2.74 nM).

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P11 acetate Chemical Structure
P11 acetate, CAS TP1879L1
Pack Size Availability Price/USD Quantity
1 mg In stock $ 82.00
5 mg In stock $ 167.00
10 mg In stock $ 283.00
25 mg In stock $ 512.00
50 mg In stock $ 743.00
100 mg In stock $ 1,050.00
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Biological Description
Chemical Properties
Storage & Solubility Information
Description P11 acetate is an integrin αvβ3-vitronectin interaction antagonist(IC50 = 2.74 nM).
Targets&IC50 αVβ3 integrin:2.74 nM
In vitro P11 acetate showed a strong antagonism against avb3-GRGDSP interaction(IC50 = 25.72 nM)[1]. P11 acetate inhibited the HUVEC proliferation due to the induction of HUVEC cell death through caspases activations and its mechanism is related with increased p53 expression[2].P11 acetate significantly inhibited bFGF-induced cell migration compared to the PBS control group[3].
Molecular Weight 720.78
Formula C30H48N12O9
CAS No. TP1879L1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

TargetMolReferences and Literature

1. Youngjin Choi, et al. Site-specific inhibition of integrin alpha v beta 3-vitronectin association by a ser-asp-val sequence through an Arg-Gly-Asp-binding site of the integrin. Proteomics. 2010 Jan;10(1):72-80. 2. Ji-Young Bang, et al. Pharmacoproteomic analysis of a novel cell-permeable peptide inhibitor of tumor-induced angiogenesis. Mol Cell Proteomics. 2011 Aug;10(8):M110.005264. 3. Yoonsuk Lee, et al. High-throughput screening of novel peptide inhibitors of an integrin receptor from the hexapeptide library by using a protein microarray chip. J Biomol Screen. 2004 Dec;9(8):687-94.

Related compound libraries

This product is contained In the following compound libraries:
Peptide Compound Library Inhibitor Library Bioactive Compounds Library Max Preclinical Compound Library Bioactive Compound Library Cytoskeletal Signaling Pathway Compound Library PPI Inhibitor Library

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Keywords

P11 acetate TP1879L1 Cytoskeletal Signaling Integrin P11 Acetate P 11 Acetate P-11 Acetate inhibitor inhibit

 

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