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Maraciclatide

Catalog No. TP2390 CAS 489427-17-0

Synonyms: NC-100692, NC 100692, NC100692

Maraciclatide is a radiopharmaceutical targeting αvβ3 integrin.

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Maraciclatide, CAS 489427-17-0

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

Maraciclatide is a radiopharmaceutical targeting αvβ3 integrin.

Synonyms	NC-100692, NC 100692, NC100692
Molecular Weight	1698.05
Formula	C72H120N20O21S3
CAS No.	489427-17-0

Storage

keep away from moisture

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Cook GJR, Azad GK, Taylor BP, Lee E, Morrison MS, Hughes S, Morris S, Rudman S, Chowdhury S, Goh V. Imaging α(v)β(3) integrin expression in skeletal metastases with (99m)Tc-maraciclatide single-photon emission computed tomography: detection and therapy response assessment. Eur J Nucl Med Mol Imaging. 2018 Jun;45(6):898-903. doi: 10.1007/s00259-017-3926-7. Epub 2018 Feb 2. PubMed PMID: 29396636; PubMed Central PMCID: PMC5915496. 2. O'Connor MK, Morrow MMB, Hunt KN, Boughey JC, Wahner-Roedler DL, Conners AL, Rhodes DJ, Hruska CB. Comparison of Tc-99m maraciclatide and Tc-99m sestamibi molecular breast imaging in patients with suspected breast cancer. EJNMMI Res. 2017 Dec;7(1):5. doi: 10.1186/s13550-017-0255-6. Epub 2017 Jan 14. PubMed PMID: 28091980; PubMed Central PMCID: PMC5237435. 3. Vancraeynest D, Roelants V, Bouzin C, Hanin FX, Walrand S, Bol V, Bol A, Pouleur AC, Pasquet A, Gerber B, Lesnik P, Huby T, Jamar F, Vanoverschelde JL. αVβ3 integrin-targeted microSPECT/CT imaging of inflamed atherosclerotic plaques in mice. EJNMMI Res. 2016 Dec;6(1):29. doi: 10.1186/s13550-016-0184-9. Epub 2016 Mar 24. PubMed PMID: 27009066; PubMed Central PMCID: PMC4805679.

Dose Conversion

You can also refer to dose conversion for different animals. More

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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An example of a molarity calculation using the molarity calculator
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
Enter 197.13 into the Molecular Weight (MW) box
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The answer of 19.713 mg appears in the Mass box

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Calculator the dilution required to prepare a stock solution

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The dilution calculator is a useful tool which allows you to calculate how to dilute a stock solution of known concentration. Enter C1, C2 & V2 to calculate V1.

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An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
Enter 10 into the Concentration (start) box and select the correct unit (millimolar)
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The answer of 100 microliter (0.1 ml) appears in the Volume (start) box

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Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed n the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Maraciclatide 489427-17-0 NC-100692 NC 100692 NC100692 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.