Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SB273005 is a potent integrin inhibitor with Ki of 1.2 nM and 0.3 nM for αvβ3 receptor and αvβ5 receptor, respectively.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 4-6 weeks | $ 1,520.00 | |
50 mg | 4-6 weeks | $ 1,980.00 | |
1 mL * 10 mM (in DMSO) | 4-6 weeks | $ 970.00 |
Description | SB273005 is a potent integrin inhibitor with Ki of 1.2 nM and 0.3 nM for αvβ3 receptor and αvβ5 receptor, respectively. |
Targets&IC50 | αvβ5 receptor:0.3 nM, αvβ3 receptor:1.2 nM |
In vitro | In vitro, SB273005 inhibits human osteoclast-mediated bone resorption with IC50 of 11 nM. [1] In blood containing MDA-MB-231 cells, a combination of SB273005 and lamifiban inhibits tumor cell adhesion to vascular extracellular matrix (ECM). [3] |
In vivo | In rat models of bone resorption and osteoporosis, SB273005 (30 mg/kg, p.o.) inhibits the parathyroid hormone-stimulated calcemic response, and inhibits bone loss. [1] In rat with adjuvant-induced arthritis, SB273005 (60 mg/kg, p.o.) significantly reduces the symptoms of adjuvant-induced arthritis. [2] SB273005 (1000 mg/kg/day, p.o.) causes acute, transient necrosis of vascular smooth muscle cell (VSMC) in aorta and renal arteries of mice. [4] In pregnant mice, SB273005 reverses the reduction of Th1 cell-produced IL-2 levels and the increase of Th2 cell-derived IL-10 levels. [5] |
Molecular Weight | 451.44 |
Formula | C22H24F3N3O4 |
CAS No. | 205678-31-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: <1 mg/mL
Ethanol: 10 mg/mL(22.2 mM)
DMSO: 83 mg/mL (183.9 mM)
You can also refer to dose conversion for different animals. More
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SB273005 205678-31-5 Cytoskeletal Signaling Integrin Inhibitor SB-273005 inhibit SB 273005 inhibitor