topoisomerase-iv — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T13231L	Trovafloxacin mesylate		Others , DNA/RNA Synthesis , Topoisomerase , Antibacterial
	Trovafloxacin is a broad-spectrum fluoroquinolone antibiotic that inhibits the activity of DNA gyrase and topoisomerase IV, enzymes involved in DNA replication. It also acts as an effective and specific inhibitor of the ...		Others , DNA/RNA Synthesis , Topoisomerase , Antibacterial
T72153	Topoisomerase IV inhibitor 1		Topoisomerase
	Topoisomerase IV inhibitor 2 (compound 7d) is a potent inhibitor of DNA topoisomerase IV (TOPO IV), exhibiting IC50 values of 0.23 μM for TOPO IV and 0.43 μM for DNA gyrase. It also demonstrates antibacterial efficacy, w...		Topoisomerase
T72154	Topoisomerase IV inhibitor 2		Topoisomerase
	Topoisomerase IV inhibitor 2 (compound 5d) is a potent inhibitor of DNA topoisomerase IV (TOPO IV), exhibiting IC50 values of 0.35 μM for TOPO IV and 0.55 μM for DNA gyrase. It also demonstrates antibacterial properties,...		Topoisomerase
T7804	Garenoxacin mesylate hydrate	Garenoxacin mesylate [USAN],BMS284756 (Mesylate hydrate)	Antibacterial
	Garenoxacin mesylate hydrate (Garenoxacin mesylate [USAN]) with potent antimicrobial activity, against common respiratory pathogens, including resistant strains.		Antibacterial
T13231	Trovafloxacin		DNA gyrase , Topoisomerase , Antibacterial , Antibiotic
	Trovafloxacin is a broad-spectrum quinolone antibiotic with potent activity against Gram-positive.		DNA gyrase , Topoisomerase , Antibacterial , Antibiotic
T7179	Garenoxacin	BMS284756	Antibacterial
	Garenoxacin (BMS284756) is a novel oral des-fluoro(6) quinolone for the treatment of Gram-positive and Gram-negative bacterial infections.		Antibacterial
T6567	Levofloxacin	Levaquin,Cravit,Tavanic,Fluoroquinolone,(-)-Ofloxacin	Topoisomerase , Antibacterial , Antibiotic
	Levofloxacin (Fluoroquinolone) is a broad-spectrum antibiotic topoisomerase II and topoisomerase IV inhibitor, used to treat respiratory, urinary tract, gastrointestinal, and abdominal infections.		Topoisomerase , Antibacterial , Antibiotic
T0902	Ofloxacin	DL8280,Hoe-280,Floxin,Tarivid,Oxaldin	Topoisomerase , Antibacterial , Antibiotic
	Ofloxacin (Oxaldin) is a fluoroquinolone antibacterial antibiotic. Ofloxacin binds to and inhibits bacterial topoisomerase II (DNA gyrase) and topoisomerase IV, enzymes involved in DNA replication and repair, resulting i...		Topoisomerase , Antibacterial , Antibiotic
T1060	Flumequine	Flumigal,R-802	Topoisomerase , Antibacterial , Antibiotic
	Flumequine (R-802) is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria. It functions by inhibiting DNA gyrase, a type II topoisomerase, and topoisomerase IV, enzymes necess...		Topoisomerase , Antibacterial , Antibiotic
T5394	Prulifloxacin	AF 3012,Pruvel,NM441	Topoisomerase , Antibacterial , Antibiotic
	Prulifloxacin (NM441) is a broad-spectrum fluoroquinolone antibiotic. It Inhibits bacterial DNA synthesis by inhibiting the activity of bacterial DNA topoisomerase II and IV.		Topoisomerase , Antibacterial , Antibiotic
T8384	Gatifloxacin hydrochloride	AM-1155 (hydrochloride),BMS-206584 (hydrochloride),PD135432 (hydrochloride)	Topoisomerase , Antibacterial , Antibiotic
	Gatifloxacin hydrochloride (AM-1155 hydrochloride) is an antibiotic of the fourth-generation fluoroquinolone family, which can inhibit the bacterial enzyme DNA rotase and topoisomerase IV.		Topoisomerase , Antibacterial , Antibiotic
T1293	Gatifloxacin	BMS 206584-01,PD 135432,CG5501,BMS-206584,AM-1155	Topoisomerase , Antibacterial , Antibiotic
	Gatifloxacin (CG5501) is an antibiotic of the fourth-generation fluoroquinolone family, that like other members of that family, inhibits the bacterial enzymes DNA gyrase and topoisomerase IV.		Topoisomerase , Antibacterial , Antibiotic
T1492	Gemifloxacin mesylate	LB-20304a,SB-265805S,Gemifloxacin mesylate	DNA gyrase , Topoisomerase , Antibacterial
	Gemifloxacin mesylate (Gemifloxacin mesylate) inhibits activities of DNA gyrase and topoisomerase IV, thereby inhibiting DNA replication and eventually bacterial growth. Gemifloxacin Mesylate is the mesylate salt form of...		DNA gyrase , Topoisomerase , Antibacterial
T71459	PD 163449
	PD 163449 is a bioactive molecule of 4-pyridone group that inhibits bacterial type IIA topoisomerase (DNA gyrase and topoisomerase IV).
T22797	Gatifloxacin mesylate		Others
	Gatifloxacin (mesylate) is an antibiotic of the fourth-generation fluoroquinolone family. It also inhibits the bacterial enzymes DNA gyrase and topoisomerase IV.		Others
T26963	CBR-2092	TNP2092,CBR2092,TNP-2092,TNP 2092
	CBR-2092 is a DNA-directed RNA polymerase and DNA topoisomerase inhibitor. CBR-2092 exhibited rifampin-like potency as an inhibitor of RNA polymerase, was an equipotent (balanced) inhibitor of DNA gyrase and DNA topoisom...
T61054	Type II topoisomerase inhibitor 1
	Type II topoisomerase inhibitor 1 is able to be used in the antibacterial area. Type II topoisomerase inhibitor 1 is a potent and selective inhibitor of E. coli DNA gyrase with a IC50 value of 1.7 nM as well as forms hyd...
T63275	NBTIs-IN-4
	NBTIs-IN-4 is able to act on a wide range of Gram-positive pathogens with significant antibacterial effects, exhibiting inhibition of DNA rotamases and topoisomerase IV with low resistance rates.
T61481	TP0480066
	TP0480066, a selective topoisomerase II inhibitor, demonstrates excellent inhibitory activity against DNA gyrase (IC50 = 1.10 nM) and topo IV (IC50 = 62.89 nM). This compound exhibits potent efficacy against multiple bac...
T11289	Finafloxacin		Others
	Finafloxacin, a fluoroquinolone antimicrobial agent from a new 8-cyano subclass, is most effective in slightly acidic environments (pH 5.0-6.0), a condition where other fluoroquinolones typically reduce in activity. It s...		Others