Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Trovafloxacin is a broad-spectrum quinolone antibiotic with potent activity against Gram-positive.
Description | Trovafloxacin is a broad-spectrum quinolone antibiotic with potent activity against Gram-positive. |
Targets&IC50 | PANX1:4 μM (IC50) |
In vitro | In HepG2 cells, Trovafloxacin (20 μM; 24 hours; ) and tumor necrosis factor (TNF; 4 ng/mL) incubation induces apoptosis and increases leakage of lactate dehydrogenase (LDH)[1]. Trovafloxacin (20 μM; 24 hours; HepG2 cells) and TNF (4 ng/mL) incubation increases expression of early NF-κB-related factors A20 and IκBα[1]. Trovafloxacin prolongs TNF-induced activation of MAPKs and IKKα/β activation in HepG2[1]. Trovafloxacin is a potent TO-PRO-3 uptake inhibitor by apoptotic cells. Trovafloxacin also inhibits ATP release from apoptotic cells. Trovafloxacin is equally active against both penicillin-susceptible and -resistant pneumococci, with MICs of 0.06-0.25 mg/mL reported for more than 700 isolates. The MICs of Trovafloxacin at which 90% of isolates are inhibited for 55 isolates of pneumococci is 0.125 μg/mL[3]. |
In vivo | In male C57BL/6 J mice, TNF-induced p65 nuclear translocation disrupted by Trovafloxacin (150 mg/kg; oral administration). Trovafloxacin treatment increases expression of early NF-κB-related factors A20 and IκBα[1]. Trovafloxacin increased serum levels of alanine amino transferases (ALT) and pro-inflammatory cytokines when administered in combination with lipopolysaccharide (LPS) or TNF to mice induces severe liver toxicity associated with vast apoptotic areas in the liver[1]. |
Molecular Weight | 416.35 |
Formula | C20H15F3N4O3 |
CAS No. | 147059-72-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: Insoluble
DMSO: 4.16 mg/ml (10 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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Trovafloxacin 147059-72-1 DNA Damage/DNA Repair Microbiology/Virology Antibiotic DNA gyrase Topoisomerase Antibacterial NF-κB inhibit PANX1 DNA gyrase LPS pro-inflammatory hepatotoxicity topoisomerase-IV Inhibitor pneumococci Bacterial broad-spectrum TNF inhibitor