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Trovafloxacin

Catalog No. T13231   CAS 147059-72-1

Trovafloxacin is a broad-spectrum quinolone antibiotic with potent activity against Gram-positive.

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Trovafloxacin Chemical Structure
Trovafloxacin, CAS 147059-72-1
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Purity: 99.27%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Trovafloxacin is a broad-spectrum quinolone antibiotic with potent activity against Gram-positive.
Targets&IC50 PANX1:4 μM (IC50)
In vitro In HepG2 cells, Trovafloxacin (20 μM; 24 hours; ) and tumor necrosis factor (TNF; 4 ng/mL) incubation induces apoptosis and increases leakage of lactate dehydrogenase (LDH)[1]. Trovafloxacin (20 μM; 24 hours; HepG2 cells) and TNF (4 ng/mL) incubation increases expression of early NF-κB-related factors A20 and IκBα[1]. Trovafloxacin prolongs TNF-induced activation of MAPKs and IKKα/β activation in HepG2[1]. Trovafloxacin is a potent TO-PRO-3 uptake inhibitor by apoptotic cells. Trovafloxacin also inhibits ATP release from apoptotic cells. Trovafloxacin is equally active against both penicillin-susceptible and -resistant pneumococci, with MICs of 0.06-0.25 mg/mL reported for more than 700 isolates. The MICs of Trovafloxacin at which 90% of isolates are inhibited for 55 isolates of pneumococci is 0.125 μg/mL[3].
In vivo In male C57BL/6 J mice, TNF-induced p65 nuclear translocation disrupted by Trovafloxacin (150 mg/kg; oral administration). Trovafloxacin treatment increases expression of early NF-κB-related factors A20 and IκBα[1]. Trovafloxacin increased serum levels of alanine amino transferases (ALT) and pro-inflammatory cytokines when administered in combination with lipopolysaccharide (LPS) or TNF to mice induces severe liver toxicity associated with vast apoptotic areas in the liver[1].
Molecular Weight 416.35
Formula C20H15F3N4O3
CAS No. 147059-72-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: Insoluble

DMSO: 4.16 mg/ml (10 mM), Sonification is recommended

TargetMolReferences and Literature

1. Giustarini G, et al. The hepatotoxic fluoroquinolone trovafloxacin disturbs TNF- and LPS-induced p65 nuclear translocation in vivo and in vitro. Toxicol Appl Pharmacol. 2020 Mar 15;391:114915. 2. Poon IK, et al. Unexpected link between an antibiotic, pannexin channels and apoptosis. Nature. 2014 Mar 20;507(7492):329-34. 3. Gootz TD, et al. Activity of the new fluoroquinolone trovafloxacin (CP-99,219) against DNA gyrase and topoisomerase IV mutants of Streptococcus pneumoniae selected in vitro. Antimicrob Agents Chemother. 1996 Dec;40(12):2691-7.

Related compound libraries

This product is contained In the following compound libraries:
ReFRAME Related Library DNA Damage & Repair Compound Library Antibiotics Library Orally Active Compound Library Approved Drug Library

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Fleroxacin Tryptanthrin Ciprofloxacin monohydrochloride Novobiocin Sodium Zoliflodacin Enoxacin hydrate Novobiocin Levofloxacin hydrochloride

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Keywords

Trovafloxacin 147059-72-1 DNA Damage/DNA Repair Microbiology/Virology Antibiotic DNA gyrase Topoisomerase Antibacterial NF-κB inhibit PANX1 DNA gyrase LPS pro-inflammatory hepatotoxicity topoisomerase-IV Inhibitor pneumococci Bacterial broad-spectrum TNF inhibitor

 

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