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Gatifloxacin

Catalog No. T1293 CAS 112811-59-3

Synonyms: BMS 206584-01, PD 135432, CG5501, BMS-206584, AM-1155

Gatifloxacin (CG5501) is an antibiotic of the fourth-generation fluoroquinolone family, that like other members of that family, inhibits the bacterial enzymes DNA gyrase and topoisomerase IV.

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Gatifloxacin, CAS 112811-59-3

Pack Size	Availability	Price/USD	Quantity
500 mg	In stock	$ 41.00
1 g	In stock	$ 48.00

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Purity: 99.96%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Gatifloxacin (CG5501) is an antibiotic of the fourth-generation fluoroquinolone family, that like other members of that family, inhibits the bacterial enzymes DNA gyrase and topoisomerase IV.
Targets&IC50	Topo II:36.7 μM (IC50)
In vitro	Gatifloxacin increases serum adrenaline levels in both normal and diabetic rats, and concurrently reduces serum glucose concentrations in these subjects.
In vivo	Gatifloxacin exhibits potent inhibitory activity against bacterial type II topoisomerases, with half-maximal inhibitory concentrations (IC50) of 13.8 mg/mL and 0.109 mg/mL for Staphylococcus aureus topoisomerase and Escherichia coli DNA gyrase, respectively. Its inhibitory effect on HeLa cell topoisomerase II is minimal, with an IC50 of 265 mg/mL. Gatifloxacin inhibits Mycobacterium tuberculosis ATCC 35801 with a minimum inhibitory concentration (MIC) of 0.125 μg/mL. When used in combination with ciprofloxacin, gatifloxacin demonstrates a synergistic effect on 19% of 31 strains of Pseudomonas aeruginosa. However, gatifloxacin's activity is two-fold lower than that of ciprofloxacin and two-fold less potent than ofloxacin against Enterobacteriaceae. Gatifloxacin shows strong antimicrobial activity against Haemophilus influenzae, Legionella, and Helicobacter pylori (MIC90s, 0.03-0.06 mg/L), and at least an eight-fold greater efficacy against Chlamydiaceae and Mycoplasmataceae (gatifloxacin MIC90s, 0.13 mg/L).

Synonyms	BMS 206584-01, PD 135432, CG5501, BMS-206584, AM-1155
Molecular Weight	375.39
Formula	C19H22FN3O4
CAS No.	112811-59-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 3.8 mg/mL (10 mM), Heating is recommended.

References and Literature

1. Alvirez-Freites EJ, et al. Antimicrob Agents Chemother, 2002, 46(4), 1022-1025. 2. Takei M, et al. Antimicrob Agents Chemother, 1998, 42(10), 2678-2681. 3. Dawis MA, et al. J Antimicrob Chemother, 2003, 51(5), 1203-1211. 4. Pankey GA, et al. Antimicrob Agents Chemother, 2005, 49(7), 2959-2964. 5. Fung-Tomc J, et al. J Antimicrob Chemother, 2000, 45(4), 437-446.

Related compound libraries

This product is contained In the following compound libraries：

Drug Repurposing Compound Library Inhibitor Library FDA-Approved & Pharmacopeia Drug Library Human Metabolite Library CNS-Penetrant Compound Library DNA Damage & Repair Compound Library Target-Focused Phenotypic Screening Library FDA-Approved Drug Library Bioactive Compound Library Anti-Aging Compound Library

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Gatifloxacin 112811-59-3 DNA Damage/DNA Repair Microbiology/Virology Topoisomerase Antibacterial Antibiotic Inhibitor S. aureus BMS 206584-01 E. coli,?Pseudomonas aeruginosa,?Micrococcus luteus hyperglycemia N. brasiliensis conjunctivitis AM1155 CG-5501 PD 135432 Bacterial PD-135432 BMS206584 inhibit CG5501 diabetic hypoglycemia AM 1155 BMS-206584 AM-1155 PD135432 actinomycetoma BMS 206584 CG 5501 inhibitor

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