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Gatifloxacin hydrochloride

Catalog No. T8384 CAS 121577-32-0

Synonyms: AM-1155 (hydrochloride), BMS-206584 (hydrochloride), PD135432 (hydrochloride)

Gatifloxacin hydrochloride (AM-1155 hydrochloride) is an antibiotic of the fourth-generation fluoroquinolone family, which can inhibit the bacterial enzyme DNA rotase and topoisomerase IV.

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Gatifloxacin hydrochloride Chemical Structure

Gatifloxacin hydrochloride, CAS 121577-32-0

Pack Size	Availability	Price/USD	Quantity
500 mg	In stock	$ 41.00
1 mL * 10 mM (in DMSO)	In stock	$ 50.00

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Purity: 100%

Purity: 99.65%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Gatifloxacin hydrochloride (AM-1155 hydrochloride) is an antibiotic of the fourth-generation fluoroquinolone family, which can inhibit the bacterial enzyme DNA rotase and topoisomerase IV.
Targets&IC50	Topo II:36.7 μM
In vivo	All eyes showed evidence of infection by 48 hours postinoculation with 36 of 41 eyes (87.8%) exhibiting moderate-to-severe keratitis. All eyes exhibited corneal healing by day 15, with no significant differences among groups. Three of 4 groups receiving gatifloxacin tended to have smaller fluorescein retention area scores than did the ciprofloxacin group. No eyes tested positive for Pseudomonas at the end of the study. No corneal precipitates were found following as many as 48 doses/day of gatifloxacin[1].
Animal Research	Heptanol-induced corneal ulcers in New Zealand White rabbits (n = 41; 8 females/group) were inoculated with 10(6) CFU of Pseudomonas aeruginosa. Gatifloxacin 0.3% dosing varied among 4 groups with frequencies of 16-48 doses/day (days 1-2), 3-16 doses/day (days 3-7), and maintenance dosing of 3-4 doses/day (days 8-22). Ciprofloxacin 0.3% was administered as labeled for corneal ulcers, with 44 doses on day 1, 16 doses on day 2, and 4 doses/day on days 3-21[1]

Synonyms	AM-1155 (hydrochloride), BMS-206584 (hydrochloride), PD135432 (hydrochloride)
Molecular Weight	411.86
Formula	C19H23ClFN3O4
CAS No.	121577-32-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 10 mg/mL (24.28 mM), Sonication is recommended.

DMSO: 5 mg/mL (12.14 mM), Sonication is recommended.

References and Literature

1. Jensen, H., et al., Comparison of ophthalmic gatifloxacin 0.3% and ciprofloxacin 0.3% in healing of corneal ulcers associated with Pseudomonas aeruginosa-induced ulcerative keratitis in rabbits. J Ocul Pharmacol Ther, 2005. 21(1): p. 36-43. 2. Fukuda, H., S. Hori, and K. Hiramatsu, Antibacterial activity of gatifloxacin (AM-1155, CG5501, BMS-206584), a newly developed fluoroquinolone, against sequentially acquired quinolone-resistant mutants and the norA transformant of Staphylococcus aureus. Antimicrob Agents Chemother, 1998. 42(8): p. 1917-22.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Drug Repurposing Compound Library Immunology/Inflammation Compound Library Anti-infective Natural Product Library Drug-induced Liver Injury (DILI) Compound Library Anti-Bacterial Compound Library FDA-Approved Drug Library Anti-Aging Compound Library Natural Product Library DNA Damage & Repair Compound Library

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Related compounds with same targets

Moxifloxacin hydrochloride Dxd Irinotecan Karenitecin LMP744 hydrochloride AuM1Phe Gatifloxacin Sparfloxacin

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Keywords

Gatifloxacin hydrochloride 121577-32-0 DNA Damage/DNA Repair Microbiology/Virology Antibiotic Antibacterial Topoisomerase AM1155 BMS-206584 E. coli,?Pseudomonas aeruginosa,?Micrococcus luteus Gatifloxacin PD-135432 BMS 206584 conjunctivitis N. brasiliensis actinomycetoma AM-1155 (hydrochloride) Inhibitor S. aureus Bacterial BMS-206584 (hydrochloride) inhibit hypoglycemia AM 1155 Gatifloxacin Hydrochloride diabetic PD135432 (hydrochloride) PD135432 hyperglycemia PD 135432 BMS206584 AM-1155 inhibitor

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