striatum — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T8702	SKF-83566		Dopamine Receptor , 5-HT Receptor , AChR
	SKF-83566 is a blood-brain permeable and orally active antagonist of D1-like dopamine receptor and a weaker competitive 5-HT2 receptor antagonist with Ki of 11 nM		Dopamine Receptor , 5-HT Receptor , AChR
T7180	Sultopride hydrochloride	LIN-1418 hydrochloride	Dopamine Receptor
	Sultopride hydrochloride (LIN-1418 hydrochloride) is a selective dopamine D2 and D3 receptor antagonist.		Dopamine Receptor
T27252	ELB-139	ELB139
	ELB-139 is a GABA A receptor agonist. ELB139 increases 5-HT in the striatum and prefrontal cortex of rats.
T14083	Abaperidone		Dopamine Receptor , 5-HT Receptor
	Abaperidone is a potent 5-HT2A receptor and dopamine D2 receptor antagonist with an IC50 of 6.2 for 5-HT2A receptors and 17 nM for dopamine D2 receptors.Abaperidone is a potentially atypical anti-psychotropic compound th...		Dopamine Receptor , 5-HT Receptor
T12483	Piperidine-MO-1		Others
	Piperidine-MO-1 is a dopamine receptor modulator, with an ED50 of 68 μmol/kg on increase of DOPAC in the rat striatum.		Others
T6951	Pramipexole dihydrochloride hydrate	Pramipexole 2HCl Monohydrate,Mirapex	Dopamine Receptor
	Pramipexole dihydrochloride hydrate (Mirapex) is the hydrochloride salt of pramipexole, a benzothiazole derivative. As a nonergot dopamine agonist, pramipexole binds to D2 and D3 dopamine receptors in the striatum and su...		Dopamine Receptor
TP1597L	Secretoneurin, rat acetate	Secretoneurin, rat acetate(149146-12-3 Free base)	Others
	Secretoneurin, rat acetate is a 33-amino acid polypeptide generated by proteolytic processing of secretogranin II (SgII). Secretoneurin, rat acetate induces dopamine release in the rat striatum in vivo and in vitro, and ...		Others
TP1920L1	Acein acetate		RAAS
	Acein acetate is a high-affinity angiotensin-converting enzyme (ACE) ligand (Kd = 2.79 nM). Concentrations up to 500 nM had no significant effect on ACE enzyme activity. Enhanced NMDA + D-serine-induced dopamine release ...		RAAS
T22781L	FFN 511 hydrochloride	FFN 511 hydrochloride(1004548-96-2 Free base)
	FFN 511 hydrochloride is a fluorescent pseudo-neurotransmitters (FFNs) targeting neuronal vesicular monoamine transporter 2 (VMA T2).FFN 511 hydrochloride inhibits the binding of 5-hydroxytryptamine to VMA T2-containing ...
T6S2227	Spinosin	Flavoayamenin	Others
	1. Spinosin (Flavoayamenin) ameliorated memory impairment induced through AβO, the serotonergic neurotransmitter system, and these effects were regulated, in part, through neuroprotective activity via the anti-inflammato...		Others
T23265	RS 67333 hydrochloride	RS 67333 (hydrochloride),RS 67333 HCl	5-HT Receptor
	RS 67333 hydrochloride (RO5203648) is a potent, selective partial agonist of the 5-HT4 receptor (5-HT4R) with a pKi value of 8.7 in guinea-pig striatum. It demonstrates lower binding affinities for other receptors, inclu...		5-HT Receptor
T37190	L-Allylglycine		Dehydrogenase , GABA Receptor
	L-Allylglycine is an amino acid derivative that reduces glutamate decarboxylase (GAD) activity by 60% when administered at a dose of 39.8 μmol/g per hour ex vivo in mouse brain preparations. L-Allylglycine (1.2 mmol/kg, ...		Dehydrogenase , GABA Receptor
T33656	Neurotensin (1-6)
	Neurotensin (1-6) affects dopamine release from striatum.
T26993	CGP 56999A	CGP56999A,CGP-56999A
	CGP 56999A is an antagonist of GABA(B) receptor, it enhances expression of brain-derived neurotrophic factor and attenuates dopamine depletion in the rat corpus striatum.
T23722	AMG-7980	AMG7980
	AMG-7980 is a highly specific phosphodiesterase 10A ligand. It shows a good uptake in the striatum.
T38221	N,N-Dipropyldopamine (hydrobromide)
	N,N-Dipropyldopamine is a dopamine receptor agonist.1,2,3 It decreases dihydrophenylalanine (DOPA) levels in the limbic forebrain and striatum of reserpinized rats (ED50s = 25 and 20 μmol/kg, respectively), as well as re...
T69449	Cyclindole
	Cyclindole is an antipsychotic with a tricyclic structure that was never marketed. It displaces spiperone binding in vitro and elevates dopamine levels in the striatum, indicating it acts as a D₂ receptor antagonist.
T36233	Dicrotalic anhydride	3-hydroxy-3-Methylglutaric anhydride	Others
	Dicrotalic anhydride(3-hydroxy-3-Methylglutaric anhydride) induces DNA damage in rat striatum.		Others
T10542	Bifeprunox		Others
	Bifeprunox is a potent partial agonist of dopamine D2-like and 5-HT1A receptor (pEC50: 6.37 for hippocampus 5-HT1A; pKis: 7.19 and 8.83 for cortex 5-HT1A and striatum D2). It is an antipsychotic for the research of schiz...		Others
T27455	GSK-215083	GSK215083
	GSK-215083 is a PET radioligand for the 5-HT6 receptor. GSK 215083 is a quinoline based compounds and acts by antagonising the 5-HT6 receptor. GSK-215083 binds to receptors 5-hydroxytrypamine-6 (5HT6) in the striatum and...