Powder: -20°C for 3 years | In solvent: -80°C for 1 year
RS 67333 hydrochloride (RO5203648) is a potent, selective partial agonist of the 5-HT4 receptor (5-HT4R) with a pKi value of 8.7 in guinea-pig striatum. It demonstrates lower binding affinities for other receptors, including 5-HT1A, 5-HT1D, 5-HT2A, 5-HT2C, dopamine D1 and D2, and muscarinic M1-M3 receptors. Notably, RS 67333 hydrochloride exhibits neuroprotective properties, rendering it useful in Alzheimer's disease research.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 31.00 | |
5 mg | In stock | $ 72.00 | |
10 mg | In stock | $ 122.00 | |
25 mg | In stock | $ 288.00 | |
50 mg | In stock | $ 452.00 | |
100 mg | In stock | $ 665.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 79.00 |
Description | RS 67333 hydrochloride (RO5203648) is a potent, selective partial agonist of the 5-HT4 receptor (5-HT4R) with a pKi value of 8.7 in guinea-pig striatum. It demonstrates lower binding affinities for other receptors, including 5-HT1A, 5-HT1D, 5-HT2A, 5-HT2C, dopamine D1 and D2, and muscarinic M1-M3 receptors. Notably, RS 67333 hydrochloride exhibits neuroprotective properties, rendering it useful in Alzheimer's disease research. |
In vitro | RS 67333 hydrochloride exhibits affinities for the sigma 1 (pKi = 8.9) and sigma 2 (pKi = 8.0) binding sites. At the 5-HT4 receptor mediating relaxation of the carbachol-precontracted oesophagus, RS 67333 hydrochloride acts as a potent (pEC50 of 8.4), partial agonists (intrinsic activities, with respect to 5-HT is 0.5) with respect to 5-HT [1]. |
Synonyms | RS 67333 (hydrochloride), RS 67333 HCl |
Molecular Weight | 389.36 |
Formula | C19H30Cl2N2O2 |
CAS No. | 168986-60-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 9mg/ml (23.1mM)
You can also refer to dose conversion for different animals. More
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RS 67333 hydrochloride 168986-60-5 GPCR/G Protein Neuroscience 5-HT Receptor RS67333 RS 67333 Hydrochloride RS-67333 RS 67333 RS-67333 Hydrochloride RS 67333 (hydrochloride) RS 67333 HCl RS67333 Hydrochloride inhibitor inhibit