replicon — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T9577	HCV-IN-31		HCV Protease
	HCV-IN-31 is a HCV inhibitor with an EC50/EC95 of 15.7 μM.		HCV Protease
T15573	Inarigivir soproxil	SB9200	HCV Protease
	Inarigivir soproxil (SB9200) is an agonist of innate immunity. It also displays effective antiviral activity against resistant hepatitis C virus (HCV) variants (EC50s of 2.2 and 1.0 μM for HCV 1a/1b in cells of genotype ...		HCV Protease
T6229	Daclatasvir	Daklinza,EBP 883,BMS-790052	HCV Protease
	Daclatasvir (EBP 883) (BMS-790052) is a highly selective inhibitor of HCV NS5A with EC50 of 9-50 pM, for a broad range of HCV replicon genotypes and the JFH-1 genotype 2a infectious virus in cell culture. Phase 3.		HCV Protease
T1786	Daclatasvir dihydrochloride	BMS-790052 dihydrochloride	HCV Protease
	Daclatasvir dihydrochloride (BMS-790052 dihydrochloride) is an orally available antiviral agent that inhibits the NS5A region of the hepatitis C virus (HCV) and is used in combination with other oral antiviral agents to ...		HCV Protease
T22142	RO8191	RO4948191,CDM-3008	HCV Protease , HBV , JAK , IFNAR , STAT
	RO8191 (CDM-3008) (CDM-3008) is an agonist of interferon (IFN) receptor.		HCV Protease , HBV , JAK , IFNAR , STAT
T16088	MK-0608		HCV Protease
	MK-0608 is an orally bioavailable HCV replication inhibitor in vitro(EC50 = 0.3 μM and EC90=1.3 μM in the subgenomic-replicon assay).		HCV Protease
TQ0162	R-1479	4'-Azidocytidine	HCV Protease
	R-1479 (4'-Azidocytidine) is an RdRp inhibitor with an IC50 value of 1.28 μM for HCV RNA replication in the HCV subgenomic replicon system.		HCV Protease
T9249	ITMN4077		Antiviral
	ITMN4077 has antiviral activity against Hepatitis C virus infected in human HuH7 cells assessed as inhibition of HCV subgenomic replicon replication with an EC50 of 2.131μM.		Antiviral
T4988	Boceprevir	SCH 503034,EBP 520	HCV Protease , SARS-CoV
	Boceprevir (SCH 503034) is a novel, potent, highly selective, orally bioavailable HCV NS3 protease inhibitor with Ki of 14 nM in both enzyme assay and EC90 of 350 nM in cell-based replicon assay.		HCV Protease , SARS-CoV
T7215	NM107	NM-107,2'-C-Methylcytidine	HCV Protease
	NM107 (2'-C-Methylcytidine) is a ribonucleoside with broad-spectrum antiviral activity, is an nucleoside inhibitor of the hepatitis C virus (HCV) NS5B polymerase, NM 107 in the wild-type replicon cells with the EC50 of 1...		HCV Protease
T60440	Antiviral agent 17
	Antiviral agent 17 (Compound 4) is an anti-infection agent that retains its strong antiviral effect in a human replicon assay with an EC50 of 0.015 μM. Antiviral agent 17 shows good antiviral activity against murine noro...
T6729	Lomibuvir	VX-222,VCH-222	HCV Protease
	Lomibuvir (VCH-222) (VX-222) is a selective, non-nucleoside allosteric inhibitor of HCV NS5B polymerase (RdRp) with a Kd of 17 nM. Lomibuvir inhibits the 1b/Con1 HCV subgenomic replicon with an EC 50 of 5.2 nM. Lomibuvir...		HCV Protease
T3334	Velpatasvir	GS-5816	HCV Protease , SARS-CoV
	Velpatasvir (GS-5816), also known as GS-5816, is a potent and selective Hepatitis C virus NS5A inhibitor. GS-5816 has demonstrated pan-genotypic activity and a high barrier to resistance in HCV replicon assays. GS-5816 d...		HCV Protease , SARS-CoV
T60531	2'-C-Methyladenosine		HCV Protease
	2'-C-Methyladenosine is an inhibitor of hepatitis C virus (HCV) replication and a ribonucleoside diphosphate reductase inhibitor from Corynebacterium renalis.2'-C-Methyladenosine inhibits HCV replicon and NS5B-catalyzed ...		HCV Protease
T6200	Ledipasvir	GS-5885	HCV Protease , SARS-CoV
	Ledipasvir (GS-5885) is a Hepatitis C Virus NS5A Inhibitor. The mechanism of action of ledipasvir is as a P-Glycoprotein Inhibitor, and Breast Cancer Resistance Protein Inhibitor.		HCV Protease , SARS-CoV
T38237	2′-O-Methylcytidine		Nucleoside Antimetabolite/Analog , HCV Protease
	2'-O-Methylcytidine is a nucleoside derivative and an inhibitor of hepatitis C virus (HCV) non-structural protein 5B (NS5B; IC50= 3.8 μM).1It inhibits HCV replication in a replicon assay (IC50= 21.2 μM). 1.Migliaccio, G....		Nucleoside Antimetabolite/Analog , HCV Protease
T27125	DBPR-110	MB110,MB 110,MB-110
	DBPR-110 is a nonstructural protein 5A (NS5A) inhibitor. DBPR-110 reduced the reporter expression of the HCV1b replicon with a EC(50) and a selective index value of 3.9 ± 0.9 pM and >12,800,000, respectively. DBPR-110 re...
T64202	HCV-IN-40
	HCV-IN-39 (Compound 18a) is a potent, orally active nucleoside inhibitor of hepatitis C virus (HCV) that acts on the GT1a replicon (EC50: 0.259 μM), GT1b replicon (EC50: 0.434 μM) and GT1b CES1 replicon (EC50. 0.069 μM).
T70274	FR171456
	FR171456 is a natural specific inhibitor of mammalian nsdhl and yeast erg26p, inhibiting an artificial hepatitis c viral replicon, and showung broad antifungal activity
T11832	Ledipasvir D-tartrate	GS-5885 D-tartrate	Others
	Ledipasvir D-tartrate with EC50 values of 34 pM against GT1a and 4 pM against GT1b replicon. is an inhibitor of the hepatitis C virus NS5A.		Others