Powder: -20°C for 3 years | In solvent: -80°C for 1 year
MK-0608 is an orally bioavailable HCV replication inhibitor in vitro(EC50 = 0.3 μM and EC90=1.3 μM in the subgenomic-replicon assay).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 74.00 | |
2 mg | In stock | $ 97.00 | |
5 mg | In stock | $ 178.00 | |
10 mg | In stock | $ 289.00 | |
25 mg | In stock | $ 552.00 | |
50 mg | In stock | $ 793.00 | |
100 mg | In stock | $ 1,090.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 193.00 |
Description | MK-0608 is an orally bioavailable HCV replication inhibitor in vitro(EC50 = 0.3 μM and EC90=1.3 μM in the subgenomic-replicon assay). |
Targets&IC50 | HCV replication:(EC50)0.3 μM |
In vivo | MK-0608 inhibit viral RNA replication in the subgenomic HCV genotype 1b replicon, with a 50% effective concentration (EC(50)) of 0.3 microM (EC(90) = 1.3 microM). A?robust antiviral effect on the administration of MK-0608 to HCV-infected chimpanzees. |
Animal Research | MK-0608 was administered to HCV-infected chimpanzees, resulting in dose- and time-dependent decreases in plasma viral loads.?In separate experiments, chimpanzees dosed for 7 days with MK-0608 at 0.2 and 2 mg per kg of body weight per day by intravenous administration experienced average reductions in viral load of 1.0 and >5 log(10) IU/ml, respectively.?Two other HCV-infected chimpanzees received daily doses of 1 mg MK-0608 per kg via oral administration.?After 37 days of oral dosing, one chimpanzee with a high starting viral load experienced a reduction in viral load of 4.6 log(10), and the viral load in the other chimpanzee fell below the limit of quantification (LOQ) of the HCV TaqMan assay (20 IU/ml).?Importantly, viral load remained below the LOQ throughout the duration of dosing and for at least 12 days after dosing ended. |
Molecular Weight | 280.28 |
Formula | C12H16N4O4 |
CAS No. | 443642-29-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 27.5 mg/mL (98.12 mM)
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
MK-0608 443642-29-3 Microbiology/Virology Proteases/Proteasome HCV Protease inhibit Inhibitor HCV MK0608 Hepatitis C virus MK 0608 inhibitor