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Daclatasvir dihydrochloride

Catalog No. T1786 CAS 1009119-65-6

Synonyms: BMS-790052 dihydrochloride

Daclatasvir dihydrochloride (BMS-790052 dihydrochloride) is an orally available antiviral agent that inhibits the NS5A region of the hepatitis C virus (HCV) and is used in combination with other oral antiviral agents to treat chronic hepatitis C. Elevations in serum enzyme levels during daclatasvir therapy are uncommon, and it has yet to be convincingly implicated in cases of clinically apparent liver injury with jaundice.

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Daclatasvir dihydrochloride Chemical Structure

Daclatasvir dihydrochloride, CAS 1009119-65-6

Pack Size	Availability	Price/USD
5 mg	In stock	$ 35.00
10 mg	In stock	$ 43.00
25 mg	In stock	$ 55.00
50 mg	In stock	$ 65.00
100 mg	In stock	$ 74.00
500 mg	In stock	$ 173.00
1 g	In stock	$ 256.00
1 mL * 10 mM (in DMSO)	In stock	$ 44.00

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Purity: 99.84%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Daclatasvir dihydrochloride (BMS-790052 dihydrochloride) is an orally available antiviral agent that inhibits the NS5A region of the hepatitis C virus (HCV) and is used in combination with other oral antiviral agents to treat chronic hepatitis C. Elevations in serum enzyme levels during daclatasvir therapy are uncommon, and it has yet to be convincingly implicated in cases of clinically apparent liver injury with jaundice.
Targets&IC50	HCV 1a:50 pM (EC50), HCV 3a:146 pM (EC50), NS5A26-202:210 nM (Kd), HCV 5a:33 pM (EC50), NS5A33-202:8 nM (Kd), HCV 4a:12 pM (EC50), OCI:3.27 µM (IC50), HCV 2a:71 pM (EC50), OATP1B:1.5 µM (IC50), HCV 1b:9 pM (EC50)
Kinase Assay	CDK assays are performed in 96-well filter plates. All CDK-cyclin kinase complexes are expressed in insect cells through baculovirus infection and purified. The substrate for the assays is a fragment (amino acids 792-928) of pRb fused to GST (GST·RB-Cterm). The total volume in each well is 0.1 mL containing a final concentration of 20 mM Tris-HCl, pH 7.4, 50 mM NaCl, 1 mM dithiothreitol, 10 mM MgCl2, 25 μM ATP (for CDK4-cyclin D1, CDK6-cyclin D2, and CDK6-cyclin D3) or 12 μM ATP (for CDK2-cyclin E, CDK2-cyclin A, and CDC2-cyclin B) containing 0.25 μCi of [γ-32P]ATP, 20 ng of enzyme, 1 μg of GST·RB-Cterm, and Palbociclib (0.001-0.1 μM). All components except the [γ-32P]ATP are added to the wells, and the plate is placed on a plate mixer for 2 min. The reaction is started by adding the [γ-32P]ATP and the plate is incubated at 25°C for 15 min. The reaction is terminated by addition of 0.1 mL of 20% trichloroacetic acid and the plate is kept at 4°C for at least 1 hour to allow the substrate to precipitate. The wells are then washed 5 times with 0.2 mL of 10% trichloroacetic acid and radioactive incorporation is determined with a β plate counter.

Synonyms	BMS-790052 dihydrochloride
Molecular Weight	811.8
Formula	C40H52Cl2N8O6
CAS No.	1009119-65-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 55 mg/mL (67.75 mM)

References and Literature

1. Fridell RA et al. Antimicrob Agents ChemOthers. 2010 Sep;54(9):3641-50.

Related compound libraries

This product is contained In the following compound libraries：

Drug Repurposing Compound Library Inhibitor Library EMA Approved Drug Library NO PAINS Compound Library Clinical Compound Library Immunology/Inflammation Compound Library FDA-Approved & Pharmacopeia Drug Library Anti-Viral Compound Library Bioactive Compounds Library Max Target-Focused Phenotypic Screening Library

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Keywords

Daclatasvir dihydrochloride 1009119-65-6 Microbiology/Virology Proteases/Proteasome HCV Protease EBP-883 BMS 790052 genotypes Inhibitor BMS790052 inhibit JFH-1 Daclatasvir BMS790052 Dihydrochloride OATP1B3 antiviral NS5A Hepatitis C virus OATP1B1 BMS-790052 dihydrochloride replicon BMS-790052 EBP883 BMS 790052 Dihydrochloride Daclatasvir Dihydrochloride HCV EBP 883 BMS-790052 Dihydrochloride inhibitor

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