pancreatic β cell — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T8982	RH01687		Others
	RH01687 is a potent β-cell protector , exhibits β-cell-protective activities against endoplasmic reticulum (ER) stress.		Others
T2055	WS3		EGFR , IκB/IKK
	WS3, a β cell proliferation inducer, regulates Erb3 binding protein-1 (EBP1) and the IκB kinase pathway.		EGFR , IκB/IKK
T15159	Dorzagliatin	HMS5552	Glucokinase
	Dorzagliatin (HMS5552) is a dual-acting glucokinase (GK) activator. It also improves glycaemic control and pancreatic β-cell function in type 2 diabetes.		Glucokinase
TP1125	Insulin(cattle)	Insulin from bovine pancreas	IGF-1R
	Insulin bovine (Insulin from bovine pancreas) is a biologically derived two-chain polypeptide hormone, synthesized in vivo by pancreatic β cells. It is frequently utilized as a growth supplement in cell culture applicati...		IGF-1R
T4400	DIM-C-pPhOH	CDIM8	Apoptosis , Others
	DIM-C-pPhOH (CDIM8) is a nur77 (NR4A1) antagonist,inhibits TGF-β induced cell migration of breast cancer cell lines,promotes ROS/endoplasmic reticulum stress and proapoptotic pathways in pancreatic cancer cell lines,mimi...		Apoptosis , Others
T6961	PX-478	PX-478 2HCl	HIF/HIF Prolyl-Hydroxylase , HIF , Autophagy
	PX-478 is a HIF-1α inhibitor with selectivity, oral activity, and blood-brain barrier permeability. PX-478 has antitumor activity and also protects pancreatic β-cell function in diabetes mellitus and is used in type 2 di...		HIF/HIF Prolyl-Hydroxylase , HIF , Autophagy
T27736	KM10103	KM-10103,KM 10103	Others
	KM10103 exhibits β-cell-protective activities against ER stress, which plays an important role in the decline in pancreatic β cell function and mass observed in type 2 diabetes.		Others
T26895	BRD0476	BRD-0476,ML 187,ML187,ML-187,BRD 0476	Others
	BRD0476 is a suppressor of pancreatic β-cell apoptosis. BRD0476 inhibits interferon-gamma (IFN-γ)-induced Janus kinase 2 (JAK2) and signal transducer and activation of transcription 1 (STAT1) signaling to promote β-cell ...		Others
TN4383	Kazinol U		IL Receptor , IκB/IKK , NOS , NF-κB
	Kazinol U may have therapeutic value in delaying pancreatic β-cell destruction in type 1 diabetes by blocking the NF-ÎºB pathway in pancreatic β-cells reduces cell damage. Kazinol U shows estrogenic activity with ligand-...		IL Receptor , IκB/IKK , NOS , NF-κB
T28157	Nephrin		Others
	Nephrin is a cell surface signaling receptor protein that regulates podocyte function and plays a role in β-cell survival signaling; it is a protein necessary for the proper functioning of the renal filtration barrier. N...		Others
T29154	WB403	WB-403,WB 403	Others
	WB403 is a TGR5 activator. WB403 significantly decreases fasting blood glucose, postprandial blood glucose and HbA1c, improves glucose tolerance in type 2 diabetic mice. WB403 increases pancreatic β-cells and restores th...		Others
T38764	Amylin (8-37), human
	Amylin (8-37), human, derived from human Amylin, possesses direct vasodilator effects in isolated mesenteric resistance arteries of rats. Human Amylin is a small pancreatic β-cell hormone that forms aggregates in the abs...
T61040	Vin-F03		Others
	Vin-F03 can be used in the research of type 2 diabetes mellitus that is an effective protective agent of pancreatic β-cells (EC50 = 0.27 μM). Vin-F03 potently promotes the survival of β-cell and protects β-cells from apo...		Others
T60743	Vin-C01		Others
	Vin-C01 can be used for the research of type 2 diabetes mellitus that is a potent protective agent of pancreatic β-cells (EC 50 = 0.22 μM). Vin-C01 effectively protects β-cells from apoptosis induced by STZ and promotes ...		Others
T35625	Aminoacetone (hydrochloride)		Others
	Aminoacetone is a threonine and glycine catabolite that can be converted to methylglyoxal by amine oxidases. It has been identified as one of several endogenous sources of methylglyoxal found in the plasma of diabetes pa...		Others
T68976	Piragliatin		Others
	Piragliatin, also known as RO4389620, is a glucokinase activator. Piragliatin greatly enhances glucose-induced pancreatic islet respiration and insulin release. Piragliatin lowers plasma glucose both in the postabsorptiv...		Others
T69380	Cinnamic acid, hydrazide		Others
	Cinnamic acid, hydrazide is an unsaturated carboxylic acid and precursor to aspartame via enzyme-catalysed amination to phenylalanine. Cinnamic acid may be useful in prevention or treatment of Diabetes through various me...		Others
T76480	Amylin (1-37) (human)
	Amylin (1-37) (human) (hIAPP (1-37)), a peptide hormone found in pancreatic beta-cell secretory granules, features an amidated C-terminus and a disulfide bond between cysteine residues 2 and 7 [1].
T25739	Linogliride	McN-3935,McN3935,McN 3935,Linogliridum,Linoglirida	Others
	Linogliride is a guanidine-based inhibitor of insulin secretion and a structural analog of pirogliride with hypoglycemic activity. It blocks ATP-sensitive potassium channels in the pancreatic beta cell membrane, thereby ...		Others
T63019	GKA50 quarterhydrate		Others
	GKA50 quarterhydrate is a potent glucokinase activator with an EC50 value of 33 nM. GKA50 quarterhydrate is a glucose-like activator of β-cell metabolism in rodent and human pancreatic islets and a Ca2+-dependent regulat...		Others