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Dorzagliatin

Catalog No. T15159 CAS 1191995-00-2

Synonyms: HMS5552

Dorzagliatin (HMS5552) is a dual-acting glucokinase (GK) activator. It also improves glycaemic control and pancreatic β-cell function in type 2 diabetes.

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Dorzagliatin, CAS 1191995-00-2

Pack Size	Availability	Price/USD
1 mg	In stock	$ 34.00
2 mg	In stock	$ 48.00
5 mg	In stock	$ 79.00
10 mg	In stock	$ 125.00
25 mg	In stock	$ 253.00
50 mg	In stock	$ 397.00
100 mg	In stock	$ 597.00
1 mL * 10 mM (in DMSO)	In stock	$ 87.00

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Purity: 99.74%

Purity: 98.52%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Dorzagliatin (HMS5552) is a dual-acting glucokinase (GK) activator. It also improves glycaemic control and pancreatic β-cell function in type 2 diabetes.
In vivo	In diabetic rats, Dorzagliatin (low-dose 10?mg/kg, and high-dose 30?mg/kg; administered intragastrically; daily 8:00 AM for one month) shows a glucose-lowering effect on the glucose levels[2].

Synonyms	HMS5552
Molecular Weight	462.93
Formula	C22H27ClN4O5
CAS No.	1191995-00-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 125 mg/mL (270.02 mM), Sonification is recommended.

References and Literature

1. Zhu XX, et al. Dorzagliatin (HMS5552), a novel dual-acting glucokinase activator, improves glycaemic control and pancreatic β-cell function in patients with type 2 diabetes: A 28-day treatment study using biomarker-guided patient selection. Diabetes Obes Metab. 2018 Sep;20(9):2113-2120. 2. Wang P, et al. Effects of a Novel Glucokinase Activator, HMS5552, on Glucose Metabolism in a Rat Model of Type 2 Diabetes Mellitus. J Diabetes Res. 2017;2017:5812607.

Related compound libraries

This product is contained In the following compound libraries：

Drug Repurposing Compound Library Anti-Cancer Metabolism Compound Library Bioactive Compound Library Human Metabolite Library Bioactive Compounds Library Max Metabolism Compound Library Glycolysis Compound Library NO PAINS Compound Library Glycometabolism Compound Library Kinase Inhibitor Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Dorzagliatin 1191995-00-2 Metabolism Glucokinase HMS5552 diabetes inhibit β-cell Hexokinase IV Inhibitor glycaemic type 2 Hexokinase D pancreatic HMS-5552 HMS 5552 inhibitor

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