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Search Results for " orthosteric "

20

Compounds

Cat No. Product Name Synonyms Targets
T9238 KI-7 Adenosine Receptor
KI-7 is an adenosine A2B receptor positive allosteric modulator.
T15812 LY2979165 mGlu2 agonist GluR
LY2979165 (mGlu2 agonist) is an orthosteric agonist of mGluR2 and can be used in studies about serving as an anti-depressant.
T29541 AC265347 AC-265347 CaSR
AC265347 is a potent calcium-sensitive receptor (CaSR) agonist and ago-PAM orthosteric modulator with antitumour activity that inhibits neuroblastoma tumour growth by inducing differentiation.AC265347 can be used to stud...
T29135 VU0422288 VU-0422288,ML-396,ML396,VU 0422288,ML 396 GluR
VU0422288 (ML396) is a potent orthosteric modulator of type III mGlu receptors (mGlus).VU0422288 shows inhibition of mGluR4, mGluR7, and mGluR8 in a calcium mobilization assay.VU0422288 can be used to study Rett syndrome...
T24827 SR 16832 SR-16832,SR16832 PPAR
SR 16832 is a dual-site PPARγ inhibitor. It also inhibits the binding of endogenous ligands and transcriptional activity of PPARγ, more effectively than the orthosteric covalent antagonist GW 9662 and T 0070907.
T20941 Cloransulam-methyl Cloransulam methyl Others
Cloransulam-methyl is an effective herbicide that is often applied to soybean fields to control broadleaf weeds.Cloransulam-methyl is rapidly metabolised in the soybean plant but is present in the soil.CBiPES hydrochlori...
T61483 GLP-1R modulator C5 Glucagon Receptor
GLP-1R modulator C5 is a small molecule GLP-1R orthosteric modulator that enhances GLP-1 binding to GLP-1R via transmembrane sites and can be used in the study of type II diabetes.
T29067 Upacicalcet PLS-240,SK-1403,AJT-240 Calcium Channel
Upacicalcet (AJT-240) is an intraventricular calcium mimetic, a SHPT available for human hemodialysis, that inhibits excessive parathyroid hormone (PTH) secretion by directly acting on parathyroid cell membrane calcium-s...
T22638 CBiPES hydrochloride CBiPES HCl GluR
CBiPES hydrochloride (CBiPES HCl) is a potent orthosteric modulator of the mGlu2 receptor with an EC50 value of 92.8 nM.CBiPES hydrochloride blocks the action of WT and mGlu(3) receptors.CBiPES hydrochloride can be used ...
T9180 LUF6096 CF-602 Adenosine Receptor
LUF6096 (CF-602) is a potent allosteric enhancer of the adenosine A3 receptor, exhibiting the capability to enhance agonist binding allosterically while demonstrating low orthosteric affinity across adenosine receptors. ...
T50048 4,4-dimethyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-2-one Others
4,4-dimethyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-2-one is a benzodiazepine derivative. It is an orthosteric modulator of the GABAA receptor and selectively binds to the benzodiazepine site of the GABAA receptor. It h...
T8963 CYM2503 Neuropeptide Y Receptor
CYM2503 is a positive allosteric modulator (PAM) of the GAL2 receptor that potentiates galanin-induced IP1 production in vitro. It has no affinity for the orthosteric galanin binding site of the receptor (as measured by ...
T35841 5-Benzyloxygramine Dopamine Receptor , 5-HT Receptor
5-Benzyloxygramine is a N protein PPI orthosteric stabilizer that exhibits both antiviral and N-NTD protein-stabilizing activities[1]. 5-benzyloxygramine stabilizes the N-NTD dimers through simultaneous hydrophobic inter...
T27961 LY593093 LY 593093,LY-593093
LY593093 is a selective partial orthosteric agonist of M1 muscarinic acetylcholine receptor.
T28070 ML381 VU 0488130,ML-381,ML 381,VU-0488130,VU0488130
ML381 is a M5-orthosteric antagonist with a high selectivity of muscarinic subtype.
T61276 CB1R Allosteric modulator 2
CB1R Allosteric modulator 2 (compound 18) is a potent allosteric modulator of the CB1R receptor. It exhibits negative modulation of the functional activity of orthosteric ligands (NAM) at CB1Rs, as demonstrated in previo...
T12423 PF-06256142 Others
PF-06256142 is a potent and selective orthosteric D1 receptor agonist(D1 EC50=30 nM ).
T62610 LY3154885
LY3154885 is an orally active dopamine D1 receptor orthosteric modulator (PAM) that reduces the risk of drug-drug interactions (DDI).
T74396 NAChR modulator-1
nAChR modulator-1, a insecticide, is a insect nAChR orthosteric modulator [1] .
T74397 NAChR modulator-2
nAChR modulator-2, a insecticide, is a insect nAChR orthosteric modulator [1] .
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