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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T9238 | KI-7 | Adenosine Receptor | |
KI-7 is an adenosine A2B receptor positive allosteric modulator. | |||
T15812 | LY2979165 | mGlu2 agonist | GluR |
LY2979165 (mGlu2 agonist) is an orthosteric agonist of mGluR2 and can be used in studies about serving as an anti-depressant. | |||
T29541 | AC265347 | AC-265347 | CaSR |
AC265347 is a potent calcium-sensitive receptor (CaSR) agonist and ago-PAM orthosteric modulator with antitumour activity that inhibits neuroblastoma tumour growth by inducing differentiation.AC265347 can be used to stud... | |||
T29135 | VU0422288 | VU-0422288,ML-396,ML396,VU 0422288,ML 396 | GluR |
VU0422288 (ML396) is a potent orthosteric modulator of type III mGlu receptors (mGlus).VU0422288 shows inhibition of mGluR4, mGluR7, and mGluR8 in a calcium mobilization assay.VU0422288 can be used to study Rett syndrome... | |||
T24827 | SR 16832 | SR-16832,SR16832 | PPAR |
SR 16832 is a dual-site PPARγ inhibitor. It also inhibits the binding of endogenous ligands and transcriptional activity of PPARγ, more effectively than the orthosteric covalent antagonist GW 9662 and T 0070907. | |||
T20941 | Cloransulam-methyl | Cloransulam methyl | Others |
Cloransulam-methyl is an effective herbicide that is often applied to soybean fields to control broadleaf weeds.Cloransulam-methyl is rapidly metabolised in the soybean plant but is present in the soil.CBiPES hydrochlori... | |||
T61483 | GLP-1R modulator C5 | Glucagon Receptor | |
GLP-1R modulator C5 is a small molecule GLP-1R orthosteric modulator that enhances GLP-1 binding to GLP-1R via transmembrane sites and can be used in the study of type II diabetes. | |||
T29067 | Upacicalcet | PLS-240,SK-1403,AJT-240 | Calcium Channel |
Upacicalcet (AJT-240) is an intraventricular calcium mimetic, a SHPT available for human hemodialysis, that inhibits excessive parathyroid hormone (PTH) secretion by directly acting on parathyroid cell membrane calcium-s... | |||
T22638 | CBiPES hydrochloride | CBiPES HCl | GluR |
CBiPES hydrochloride (CBiPES HCl) is a potent orthosteric modulator of the mGlu2 receptor with an EC50 value of 92.8 nM.CBiPES hydrochloride blocks the action of WT and mGlu(3) receptors.CBiPES hydrochloride can be used ... | |||
T9180 | LUF6096 | CF-602 | Adenosine Receptor |
LUF6096 (CF-602) is a potent allosteric enhancer of the adenosine A3 receptor, exhibiting the capability to enhance agonist binding allosterically while demonstrating low orthosteric affinity across adenosine receptors. ... | |||
T50048 | 4,4-dimethyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-2-one | Others | |
4,4-dimethyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-2-one is a benzodiazepine derivative. It is an orthosteric modulator of the GABAA receptor and selectively binds to the benzodiazepine site of the GABAA receptor. It h... | |||
T8963 | CYM2503 | Neuropeptide Y Receptor | |
CYM2503 is a positive allosteric modulator (PAM) of the GAL2 receptor that potentiates galanin-induced IP1 production in vitro. It has no affinity for the orthosteric galanin binding site of the receptor (as measured by ... | |||
T35841 | 5-Benzyloxygramine | Dopamine Receptor , 5-HT Receptor | |
5-Benzyloxygramine is a N protein PPI orthosteric stabilizer that exhibits both antiviral and N-NTD protein-stabilizing activities[1]. 5-benzyloxygramine stabilizes the N-NTD dimers through simultaneous hydrophobic inter... | |||
T27961 | LY593093 | LY 593093,LY-593093 | |
LY593093 is a selective partial orthosteric agonist of M1 muscarinic acetylcholine receptor. | |||
T28070 | ML381 | VU 0488130,ML-381,ML 381,VU-0488130,VU0488130 | |
ML381 is a M5-orthosteric antagonist with a high selectivity of muscarinic subtype. | |||
T61276 | CB1R Allosteric modulator 2 | ||
CB1R Allosteric modulator 2 (compound 18) is a potent allosteric modulator of the CB1R receptor. It exhibits negative modulation of the functional activity of orthosteric ligands (NAM) at CB1Rs, as demonstrated in previo... | |||
T12423 | PF-06256142 | Others | |
PF-06256142 is a potent and selective orthosteric D1 receptor agonist(D1 EC50=30 nM ). | |||
T62610 | LY3154885 | ||
LY3154885 is an orally active dopamine D1 receptor orthosteric modulator (PAM) that reduces the risk of drug-drug interactions (DDI). | |||
T74396 | NAChR modulator-1 | ||
nAChR modulator-1, a insecticide, is a insect nAChR orthosteric modulator [1] . | |||
T74397 | NAChR modulator-2 | ||
nAChR modulator-2, a insecticide, is a insect nAChR orthosteric modulator [1] . |