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Search Results for " muscarinic-m4 "

20

Compounds

Cat No. Product Name Synonyms Targets
T9889 M4 mAChR agonist-1  4-Piperidinecarboxamide, 1-(5,6-dimethylthieno[2,3-d]pyrimidin-4-yl)- AChR
M4 mAChR agonist-1 (4-Piperidinecarboxamide, 1-(5,6-dimethylthieno[2,3-d]pyrimidin-4-yl)-) is an effective agonist of M4 mAChR (EC50 >10 μM).
T81893 M1/M4 muscarinic agonist 2
Compound 40 is a selective M1/M4 muscarinic antagonist with an IC50 of 19 nM for M1 receptors and 42 nM for M4 receptors [1].
T4494 CLOZAPINE N-OXIDE Dopamine Receptor , 5-HT Receptor , AChR , Drug Metabolite
Clozapine N-oxide is the major metabolite of Clozapine and is blood-brain barrier permeable. Clozapine N-oxide is an agonist of DREADDs and activates the DREADD receptors hM3Dq and hM4Di. Clozapine N-oxide is also a dopa...
T23297 (S)-(+)-Dimethindene maleate AChR , Histamine Receptor
(S)-(+)-Dimethindene maleate is an orally available, selective muscarinic M2 receptor and histamine H1 receptor antagonist that inhibits muscarinic M1, M3, and M4 receptors.
T6575 LY2119620 AChR
LY2119620 is a specific, and allosteric agonist of human M2 and M4 muscarinic acetylcholine receptors.
T17244 VU0467154 AChR
VU0467154 is a positive allosteric modulator of the M4 muscarinic acetylcholine receptor. The response to ACh with pEC50s of 7.75, 6.2, and 6 for a rat, human, and cynomolgus monkey M4 receptor, respectively.
T9694 Emraclidine CVL-231 AChR
Emraclidine (CVL-231) is a muscarinic M4 receptor positive allosteric modulator and can be used in neurological diseases studies.
T8219 VU0238441 AChR
VU0238441 is agonist of Muscarinic acetylcholine receptor M5 (human) with EC50 of 2.1μM.
T0862 Diphenidol hydrochloride Diphenidol HCl,Difenidol hydrochloride Sodium Channel , AChR
Diphenidol hydrochloride (Difenidol hydrochloride), a muscarinic antagonist, is employed as an anti-vertigo and as an antiemetic drug.
T1475 Fesoterodine fumarate Toviaz,SPM 907 AChR
Fesoterodine fumarate (Toviaz) is the fumarate salt form of fesoterodine, a competitive muscarinic receptor antagonist with muscle relaxant and urinary antispasmodic properties. Fesoterodine is rapidly hydrolyzed in vivo...
T1281 Tropicamide Ro 1-7683 AChR
Tropicamide (Ro 1-7683) is a synthetic muscarinic antagonist with actions similar to atropine and with an anticholinergic property. Upon ocular administration, tropicamide binds to and blocks the muscarinic receptors in ...
T23124 PD 102807 Others
M4 muscarinic receptor antagonist
T39543 VU6000918
VU6000918 is a positive allosteric modulator that targets the muscarinic acetylcholine receptor subtype M4. It exhibits a half maximal effective concentration (EC50) of 19 nM for the human M4 receptor.
T13924 Thiochrome Others
Thiochrome is a selective enhancer of M4 muscarinic receptor of acetylcholine (ACh) affinity.
T17245 VU0467485 AZ13713945 Others
VU0467485 is a potent and selective muscarinic acetylcholine receptor 4 positive allosteric modulator. VU0467485 potentiates the activity of ACh at M4 (EC50s: 26.6 nM and 78.8 nM at the rat and human M4 receptors, respec...
T13322 VU6005806 AZN-00016130 Others
VU6005806 is a potent positive allosteric modulator (PAM) of muscarinic acetylcholine receptor subtype 4 (M4) (EC50s: 94 nM, 28 nM, 87 nM, and 68 nM for human, rat, dog, and cyno M4, respectively), and used in the study ...
T39010 Xanomeline tartrate LY 246708 tartrate,Xanomeline tartrate
Xanomeline (LY 246708), a potent agonist of muscarinic M1/M4 receptors, exhibits antipsychotic-like activity and enhances neuronal excitability. It is a valuable compound for studying schizophrenia.
T36662 Imidafenacin Metabolite M4 Imidafenacin Metabolite M4
Imidafenacin metabolite M4 is a metabolite of the muscarinic acetylcholine receptor antagonist imidafenacin.1It is formed from imidafenacin by the cytochrome P450 (CYP) isoform CYP3A4. 1.Kanayama, N., Kanari, C., Masuda,...
T23763 Atropine Oxide NSC 72861,NSC72861,NSC-72861
Atropine Oxide is a derivative of Atropine. Atropine is a competitive antagonist of the muscarinic acetylcholine receptor types M1, M2, M3, M4, and M5. Atropine is a medication to treat certain types of nerve agents and ...
T16443 PCS1055 dihydrochloride Others
PCS1055 dihydrochloride is an effective, selective, and competitive muscarinic M4 receptor antagonist (IC50: 18.1 nM and a Kd: 5.72 nM). PCS1055 dihydrochloride is also a potent AChE inhibitor (IC50 s: 22 nM and 120 nM f...
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