kynurenine — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T4928	L-Kynurenine	(S)-Kynurenine	AhR , Aryl Hydrocarbon Receptor , Endogenous Metabolite
	L-Kynurenine ((S)-Kynurenine) is a key intermediate in the breakdown pathway of tryptophan. L-Kynurenine is a substrate of kynureninase, KMO, and KAT associated with the suppression of antitumor immune responses. It has ...		AhR , Aryl Hydrocarbon Receptor , Endogenous Metabolite
T10938	D-Kynurenine	(R)-2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid,ZINC901103	GPR , AhR , Endogenous Metabolite
	D-Kynurenine (ZINC901103) is a metabolite of D-tryptophan and an agonist of GPR109B. D-Kynurenine activates AhR and promotes the conversion of the epithelium to mesenchyme. D-Kynurenine serves as a substrate in the fluor...		GPR , AhR , Endogenous Metabolite
T3011L	Kynurenine sulfate monohydrate	L-Kynurenine sulfate monohydrate
	Kynurenine sulfate monohydrate is a precursor of kynurenic acid which is the only recognized endogenous excitatory amino acid receptor antagonist agent in the central nervous system. L-Kyn is known to be a pigment genera...
T3011	2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid	Kynurenine,Dl-Kynurenine,Kynurenin,3-Anthraniloylalanine	Others , Endogenous Metabolite
	2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid (3-Anthraniloylalanine) is a ketone and an amino acid derivative with diverse biological functions, including vasodilatory, immunoregulatory and neuromodulatory activities. 2-...		Others , Endogenous Metabolite
T37683	3-Hydroxykynurenine	3-hydroxy-DL-Kynurenine,DL-3-Hydroxykynurenine	Others
	3-Hydroxykynurenine (3-hydroxy-DL-Kynurenine) is an active metabolite of tryptophan and inhibits yeast and rat liver aldehyde dehydrogenase by 97 and 69%.		Others
T72430	L-Kynurenine sulfate
	L-Kynurenine sulfate, an aryl hydrocarbon receptor (AHR) agonist, activates AHR-driven polarization of naive T cells towards the anti-inflammatory Treg phenotype.
T1896	Ro 61-8048		Hydroxylase
	Ro 61-8048 is a potent and selective inhibitor of kynurenine hydroxylase with an IC50 value of 37 nM.		Hydroxylase
T4410	LM10		Others
	Selective tryptophan 2, 3-dioxygenase (TDO) inhibitor (IC50 values are 0.62 and 2 μM for human and mouse TDO, respectively). Exhibits selectivity for TDO over IDO, MAO-A, MAO-B, and a panel of receptors and transporters....		Others
T71760	4-Chlorokynurenine
	4-Chlorokynurenine is a prodrug of 7-Cl-kynurenic acid (7-Cl-KYNA), a potent, selective antagonist of the NMDA/glycine receptor.
T4096	Quinolinic acid	pyridine-2,3-dicarboxylic acid,QUIN	Endogenous Metabolite , NMDAR , iGluR
	Quinolinic acid (QUIN) is an endogenous N-methyl-D-aspartate (NMDA) receptor agonist synthesized from L-tryptophan via the kynurenine pathway.		Endogenous Metabolite , NMDAR , iGluR
T28368	PF-04859989 HCl	PF 04859989,PF04859989,PF-04859989HCl,PF-04859989	Others
	PF-04859989 HCl is a brain-penetrable irreversible inhibitor of kynurenine amino transferase II (KAT II), the enzyme responsible for most of the brain synthesis of kynurenic acid. PF-04859989 HCl has been implicated in s...		Others
T4707	3-Hydroxyanthranilic acid	3-HYDROXY-2-AMINOBENZOIC ACID	Others , Endogenous Metabolite
	3-Hydroxyanthranilic acid (3-HYDROXY-2-AMINOBENZOIC ACID), also known as 2-amino-3-hydroxy-benzoate or 3-ohaa, belongs to the class of organic compounds known as hydroxybenzoic acid derivatives. 3-Hydroxyanthranilic acid...		Others , Endogenous Metabolite
T26785	BFF122	BFF 122,BF5,BFF-122
	BFF122 is an inhibitor of kynurenine aminotransferase II (KAT II).
T70041	GSK065
	GSK065 is a potent inhibitor of kynurenine-3-monooxygenase (KMO).
T70701	CHDI340246
	CHDI-340246 is a potent and selective kynurenine mono-oxygenase (KMO) inhibitor.
T13258L	UPF-648		Others
	UPF-648 is a potent kynurenine 3-monooxygenase inhibitor. It also shows highly active at 1 uM (81 ± 10% KMO inhibition).		Others
T13258	UPF-648 sodium salt		Others
	UPF-648 sodium salt is an inhibitor of kynurenine 3-monooxygenase (KMO) and exhibits highly active at 1 uM (81 ± 10% KMO inhibition).		Others
T11470	GSK 366		Hydroxylase
	GSK 366 is a potent kynurenine-3-monooxygenase (KMO) inhibitor (IC50s: 0.7 nM and 2.3 nM for P. fluorescens-KMO and human KMO).		Hydroxylase
T15426	GSK180		Hydroxylase
	GSK180 is a selective competitive inhibitor of kynurenine 3-monooxygenase (KMO; IC50: ~6 nM), an enzyme involved in tryptophan metabolism.		Hydroxylase
T69944	NLG802 HCl
	NLG802 is an orally bioavailable prodrug of indoximod, a methylated tryptophan, with immune checkpoint inhibitory and antineoplastic activities. Upon oral administration, the indoximod prodrug NLG802 is converted to indo...