insomnia — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T1463	Ramelteon	TAK-375	Melatonin Receptor , MT Receptor
	Ramelteon (TAK-375) is a Melatonin Receptor Agonist. The mechanism of action of ramelteon is as a Melatonin Receptor Agonist.		Melatonin Receptor , MT Receptor
T12877L	Seltorexant	JNJ-42847922	OX Receptor
	Seltorexant (JNJ-42847922) crosses the blood-brain barrier and quickly occupies OX2R binding sites in the rat brain. Seltorexant is a high-affinity and selective orexin-2 receptor antagonist (pKi: 8.0 and 8.1 for human a...		OX Receptor
T3722	MK-1064	Urokinase inhibitor 1,MK 1064	OX Receptor
	MK-1064 (Urokinase inhibitor 1) is a selective orexin 2 receptor antagonist (2-SORA).		OX Receptor
T14983	Clomethiazole	Distraneurin,Chlormethiazole,5-(2-CHLOROETHYL)-4-METHYLTHIAZOLE	P450 , GABA Receptor
	Clomethiazole (Distraneurin) is an orally active GABAA agonist and it is an anticonvulsant agent. It also has the potential for treating convulsive status epilepticus. Chlormethiazole inhibits cytochrome P450 isoforms: C...		P450 , GABA Receptor
T41143	PCPA methyl ester hydrochloride	4-Chloro-DL-phenylalanine methyl ester hydrochloride	5-HT Receptor , Hydroxylase
	pCPA methyl ester hydrochloride (4-Chloro-DL-phenylalanine methyl ester hydrochloride) is an inhibitor of tryptophan hydroxylase inhibitor and 5-HT synthesis. pCPA methyl ester hydrochloride is permeable across the blood...		5-HT Receptor , Hydroxylase
TL0002	Liquiritin apioside		Others
	Liquiritin Apioside is one of the main active components in Suan-Zao-Ren decoction as a treatment for insomnia.		Others
T67782	Daridorexant hydrochloride	Nemorexant hydrochloride,Quviviq	OX Receptor
	Daridorexant hydrochloride (Nemorexant hydrochloride) is a New Dual Orexin Receptor Antagonist. Daridorexant hydrochloride can be used for Insomnia research.		OX Receptor
T5500	DORA-22		OX Receptor
	DORA-22 is a dual orexin receptor antagonist, improves mild stress-induced insomnia with minimal effect on memory		OX Receptor
T30188L	Atagabalin HCl	PD-0200390 HCl,Atagabalin HCl(223445-75-8 Free base）	Calcium Channel
	Atagabalin HCl is a novel voltage-dependent calcium channel (VDCC) α2δ subunit (1 and 2) ligand that affects slow-wave sleep and can be used to treat insomnia.		Calcium Channel
T37979	N-Desmethyl Pimavanserin	AC-279	5-HT Receptor
	N-Desmethyl Pimavanserin (AC-279) is the active metabolite of Pimavanserin, a 5-HT2A receptor inverse agonist, which is used in the treatment of sleep disorders such as insomnia.		5-HT Receptor
T1619	Trazodone hydrochloride	KB-831,Trazodone HCl,AF-1161	5-HT Receptor , Adrenergic Receptor , Histamine Receptor
	Trazodone hydrochloride (Trazodone HCl) is a serotonin uptake inhibitor that is used as an antidepressive agent. It has been shown to be effective in patients with major depressive disorders and other subsets of depressi...		5-HT Receptor , Adrenergic Receptor , Histamine Receptor
T22530	6-Chloromelatonin		Melatonin Receptor , Dopamine Receptor
	6-Chloromelatonin is a potent melatonin receptor agonist, a 5-methoxyindole compound that competes for the same presynaptic melatonin receptor sites in the rabbit retina and inhibits the calcium-dependent release of [3H]...		Melatonin Receptor , Dopamine Receptor
T69715	ORN-0829 hydrate
	ORN-0829 hydrate is a potent dual orexin 1/2 receptor antagonist for the treatment of insomnia.
T61088	Propiomazine
	Propiomazine is an orally active antihistamine agent that possesses sedative properties. It finds utility in insomnia research [1] [2].
T29008	Triclofos Sodium	SCH-10159,SCH 10159,SCH10159
	Triclofos Sodium is used to treat insomnia and used for sedation.
T26061	Reposal	WT-161,Reposamal,Reposal novo,WT161,WT 161
	Reposal is a barbiturate derivative invented in the 1960s in Denmark. It has hypnotic, sedative, and anticonvulsant properties, and was used primarily for the therapy of insomnia.
T69063	Orvepitant
	Orvepitant is a potent and selective NK1 antagonist, which may be potentially useful for patients with major depressive disorder (MDD), anxiety and insomnia.
T68469	NBI-75043
	NBI-75043 is a histamine H1 receptor antagonist, for potential use in the treatment of insomnia.
T32105	Cipepofol	HSK3486,HSK 3486,HSK-3486
	HSK3486 is similar to propofol and is a general anesthetic, which may have therapeutic potential in insomnia, migraine, anxiety, analgesia, and other aspects.
T22357	Lobeline sulfate	Lobelin sulphate	Others
	Lobelin sulphate is an alkaloid that has actions similar to nicotine on nicotinic cholinergic receptors but is less potent. It has a variety of therapeutic uses including in insomnia, and smoking cessation, peripheral va...		Others