inhaled — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T25376	Ensifentrine	Ensifentrina,Ensifentrinum	PDE
	Ensifentrine (Ensifentrinum) is a PDE3/4 inhibitor, although its affinity for PDE3(IC50: 0.4 nM) is 3,440 times higher than that for PDE4(IC50: 1479 nM), that is under clinical development for the treatment of asthma and...		PDE
T9124	Laninamivir octanoate	CS-8958	Influenza Virus
	Laninamivir octanoate (CS-8958) is a long acting influenza neuraminidase (NA) inhibitor which shows superior anti-influenza virus activity.		Influenza Virus
T0094	Budesonide	Entocort,Pulmicort,Rhinocort	Glucocorticoid Receptor
	Budesonide (Pulmicort), an anti-inflammatory corticosteroid, has shown the effective glucocorticoid activitie and few mineralocorticoid activities. According to reports, Budesonide has extensively inhibitory effects agai...		Glucocorticoid Receptor
T5159	Olodaterol hydrochloride	BI-1744 HCl,BI 1744 hydrochloride	Adrenergic Receptor
	Olodaterol hydrochloride (BI-1744 HCl) is a novel, long-acting β2-adrenergic agonist (EC50s: 97.7 nM for the human β2-adrenoceptor) that exerts its pharmacological effect by binding and activating β2-adrenergic receptors...		Adrenergic Receptor
T5121	TD139		Galectin
	TD139 is an inhaled galectin-3 inhibitor (Kd: 14 nM).		Galectin
T9826	GDC-0214		JAK
	GDC-0214 is an inhaled small-molecule JAK1 inhibitor and reduces fractional exhaled nitric oxide (Feno).		JAK
T8900	Seralutinib	GB002	PDGFR
	Seralutinib (GB002) is an inhibitor of inhaled PDGFRα and PDGFRβ. It is used in the study for pulmonary arterial hypertension.		PDGFR
T14377	AZD5423		Glucocorticoid Receptor
	AZD5423 is an inhaled, potent, selective, and non-steroidal modulator of glucocorticoid receptor (GR) and it effectively reduces allergen-induced responses in subjects with mild allergic asthma.		Glucocorticoid Receptor
T72918	JNJ-49095397	RV568
	JNJ-49095397 (RV568), an inhaled narrow-spectrum kinase inhibitor (NSKI), targets the α and γ isoforms of p38 MAPK and the SRC kinase family, particularly haematopoietic kinase (HCK). Demonstrating potent anti-inflammato...
T35319	Zy 15109	N-Acetyl-aspartyl magnesium glutamate,Zy15109,Magnesium N-acetyl-aspartylglutamate
	Zy 15109 can be used as inhaled mast cell stabilizer.
T39684	AZD8154	AZD8154
	AZD8154 is a newly developed inhaled compound that selectively inhibits dual PI3Kγδ, aimed at treating airway inflammatory diseases.
T30264	Navafenterol	AZD8871,LAS-191351,AZD 8871,LAS191351,AZD-8871,LAS 191351
	AZD-8871 can present a novel treatment approach to chronic obstructive pulmonary disease [COPD] and potentially also asthma (in combination with an inhaled corticosteroid [ICS]).
T25136	Aztreonam lysine	Corus 1020,Corus1020,Corus-1020,Aztreonam lysinate
	Aztreonam lysine is an inhaled anti-pseudomonal treatment for people who have pulmonary Pseudomonas aeruginosa infection with cystic fibrosis (CF).
T70402	LAS195319
	LAS195319 is a potent and selective inhaled PI3Kδ Inhibitor (IC50 = 0.5 nM) for the Treatment of Respiratory Diseases.
T68272	Batefenterol Succinate
	Batefenterol Succinate is a first-in-class inhaled bifunctional bronchodilator possessing muscarinic receptor antagonist and β2-adrenoceptor agonist properties.
T29518	Abediterol	LAS100977,LAS 100977,LAS-100977
	Abediterol (LAS100977) is a new potent, long-acting inhaled beta (2) -adrenergic receptor agonist being developed for the treatment of asthma and chronic obstructive pulmonary disease.
T16439	PC786		Others
	PC786 shows effective antiviral activity against RSV-A (IC50 <0.09 to 0.71 nM) and RSV-B (IC50, 1.3 to 50.6 nM). PC786 is an inhaled respiratory syncytial virus L protein polymerase inhibitor.		Others
T67962	Sulukast
	Sulukast is a potent inhaled leukotriene antagonist, which was found to be effective in preventing both leukotriene_x0002_and antigen-induced bronchospasm in guinea-pigs.
T16477	PF-03715455		p38 MAPK
	PF-03715455 potently inhibits LPS-induced TNFα production in human whole blood (IC50=1.7 nM). PF-03715455 is an effective inhibitor of inhaled p38 MAPK. PF-03715455 displays some selectivity for p38α over p38β (respectiv...		p38 MAPK
T63709	Nezulcitinib
	Nezulcitinib (TD-0903) is an inhaled, lung-selective inhibitor of pan-Janus kinase (JAK) that can be used to study COVID-19-associated acute lung injury and impaired oxygenation.