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TD139

Catalog No. T5121 CAS 1450824-22-2

TD139 is an inhaled galectin-3 inhibitor (Kd: 14 nM).

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TD139, CAS 1450824-22-2

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	TD139 is an inhaled galectin-3 inhibitor (Kd: 14 nM).
Targets&IC50	galectin-3:14 nM (Kd)
In vitro	TD139 has a high affinity for galectin-3 with a Kd of 14 nM and 10 nM for galectin-1, but low affinity for galectins 2, 4N, 4C, 7, 8N, or 9N [1].
In vivo	In primary lung AECs TD139 reduces TGF-β1–induced β-catenin translocation to the nucleus, with most of the β-catenin remaining at the cell surface. TD139 blocks TGF-β1–induced β-catenin phosphorylation. A marked reduction in fibrosis and β-catenin activation accompanied by the decreased galectin-3 expression is observed in the lungs of WT mice treated with TD139 [1]. Pretreatment of WT C57BL/6 mice with TD139 leads to the attenuation of liver injury and milder infiltration of IFNγ- and IL-17- and -4-producing CD4(+) T cells, as well as an increase in the total number of IL-10-producing CD4(+) T cells and F4/80(+) CD206(+) alternatively activates macrophages and prevents the apoptosis of liver-infiltrating MNCs [2].

Molecular Weight	648.64
Formula	C28H30F2N6O8S
CAS No.	1450824-22-2

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

H2O: Insoluble

Ethanol: 3 mg/mL

DMSO: 5 mg/mL

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Mackinnon AC, et al. Regulation of transforming growth factor-β1-driven lung fibrosis by galectin-3. Am J Respir Crit Care Med. 2012 Mar 1;185(5):537-46. 2. Volarevic V, et al. Galectin-3 deficiency prevents concanavalin A-induced hepatitis in mice. Hepatology. 2012 Jun;55(6):1954-64.

Citations

1. Liu Y, Zhao C, Meng J, et al. Galectin-3 regulates microglial activation and promotes inflammation through TLR4/MyD88/NF-kB in experimental autoimmune uveitis. Clinical Immunology. 2022: 108939.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Immunology/Inflammation Compound Library Anti-Metabolism Disease Compound Library Drug Repurposing Compound Library Nonsteroidal Anti-Inflammatory Compound Library Anti-Fibrosis Compound Library Bioactive Compound Library Clinical Compound Library

Related Products

Related compounds with same targets

TD139 Thiodigalactoside OTX008 GB1107 G3-C12 acetate(848301-94-0 free base)

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Keywords

TD139 1450824-22-2 Immunology/Inflammation Galectin TD-139 Inhibitor inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.