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TD139

Catalog No. T5121 CAS 1450824-22-2

TD139 is an inhaled galectin-3 inhibitor (Kd: 14 nM).

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TD139, CAS 1450824-22-2

Pack Size	Availability	Price/USD
1 mg	In stock	$ 98.00
2 mg	In stock	$ 162.00
5 mg	In stock	$ 277.00
10 mg	In stock	$ 449.00
25 mg	In stock	$ 673.00
50 mg	In stock	$ 958.00
100 mg	In stock	$ 1,290.00

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Purity: 99.48%

Purity: 99.05%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	TD139 is an inhaled galectin-3 inhibitor (Kd: 14 nM).
Targets&IC50	GAL3:14 nM (Kd)
In vitro	TD139 has a high affinity for galectin-3 with a Kd of 14 nM and 10 nM for galectin-1, but low affinity for galectins 2, 4N, 4C, 7, 8N, or 9N [1].
In vivo	In primary lung AECs TD139 reduces TGF-β1–induced β-catenin translocation to the nucleus, with most of the β-catenin remaining at the cell surface. TD139 blocks TGF-β1–induced β-catenin phosphorylation. A marked reduction in fibrosis and β-catenin activation accompanied by the decreased galectin-3 expression is observed in the lungs of WT mice treated with TD139 [1]. Pretreatment of WT C57BL/6 mice with TD139 leads to the attenuation of liver injury and milder infiltration of IFNγ- and IL-17- and -4-producing CD4(+) T cells, as well as an increase in the total number of IL-10-producing CD4(+) T cells and F4/80(+) CD206(+) alternatively activates macrophages and prevents the apoptosis of liver-infiltrating MNCs [2].

Molecular Weight	648.64
Formula	C28H30F2N6O8S
CAS No.	1450824-22-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: Insoluble

Ethanol: 3 mg/mL

DMSO: 55 mg/mL (84.79 mM)

References and Literature

1. Mackinnon AC, et al. Regulation of transforming growth factor-β1-driven lung fibrosis by galectin-3. Am J Respir Crit Care Med. 2012 Mar 1;185(5):537-46. 2. Volarevic V, et al. Galectin-3 deficiency prevents concanavalin A-induced hepatitis in mice. Hepatology. 2012 Jun;55(6):1954-64.

Citations

1. Liu Y, Zhao C, Meng J, et al. Galectin-3 regulates microglial activation and promotes inflammation through TLR4/MyD88/NF-kB in experimental autoimmune uveitis. Clinical Immunology. 2022: 108939. 2. Xiao H, Wang T, Gao B, et al.The effects of a galectin‐3 inhibitor on bladder pain syndrome in mice with cyclophosphamide‐induced cystitis.Neurourology and Urodynamics.2024

Related compound libraries

This product is contained In the following compound libraries：

Drug Repurposing Compound Library Inhibitor Library Bioactive Compound Library Anti-Metabolism Disease Compound Library ReFRAME Related Library NO PAINS Compound Library Clinical Compound Library Nonsteroidal Anti-Inflammatory Compound Library Immunology/Inflammation Compound Library Bioactive Compounds Library Max

Related Products

Related compounds with same targets

G3-C12 acetate(848301-94-0 free base) Galectin-3 antagonist 2 OTX008 GB1107 Galectin-3/galectin-8-IN-2 Galectin-3/galectin-8-IN-1 Thiodigalactoside DB21, Galectin-1 Antagonist

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Keywords

TD139 1450824-22-2 Immunology/Inflammation Galectin TD-139 TD 139 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.