glucocerebrosidase — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T78573	Glucocerebrosidase	GCase,Glucosylceramidase	Endogenous Metabolite
	Glucocerebrosidase (Glucosylceramidase; GBA), a lysosomal enzyme, catalyzes the hydrolysis of the β-glucosidic linkage in glucocerebroside (GC) to yield glucose and ceramide [1].		Endogenous Metabolite
T60353	Glucocerebrosidase-IN-1
	Glucocerebrosidase-IN-1 (compound 11a) is a potent and selective GCase (glucocerebrosidase) inhibitor, with an IC 50 of 29.3 μM and a K i of 18.5 μM. Due to GCase involvement in pathological disorders consequent to enzym...
T78671	Glucocerebrosidase-IN-1 hydrochloride		Glucosidase
	Glucocerebrosidase-IN-1 (compound 11a) hydrochloride is a potent, selective GCase (glucocerebrosidase) inhibitor with IC50 and Ki values of 29.3 μM and 18.5 μM, respectively. It is utilized in the research of Gaucher dis...		Glucosidase
T8986	ML198		Glucokinase
	ML198 is a novel activator and non-inhibitory chaperone of glucocerebrosidase. ML198 serves as a starting point to develop a novel approach towards small molecule treatment for patients suffering from Gaucher disease.		Glucokinase
T0920	Ambroxol	Ambroxolum,NA-872	P450 , Autophagy
	Ambroxol (NA-872) is a secretolytic agent used in the treatment of respiratory diseases associated with viscid or excessive mucus. It is the active ingredient of Mucosolvan, Lasolvan or Mucoangin. The substance is a muco...		P450 , Autophagy
T6234	Ambroxol hydrochloride	Mucosolvan,Mucoangin,Ambroxol HCl	Sodium Channel , Autophagy
	Ambroxol hydrochloride (Mucosolvan) is a metabolite of BROMHEXINE that stimulates mucociliary action and clears the air passages in the respiratory tract. It is usually administered as the hydrochloride.		Sodium Channel , Autophagy
T40544	NCGC00092410	ML008	Glucosidase
	NCGC00092410 (ML008) is a glucocerebrosidase (GC) inhibitor with IC50 value of 31 nM. It can be used for the study of Gaucher disease caused by mutation of glucocerebrase gene.		Glucosidase
T8989	NCGC 607	NCGC607	Others
	NCGC 607 is a a noninhibitory chaperone of glucocerebrosidase (GCase).		Others
T60048	WAY-640509		Glucokinase
	WAY-640509 is a glucocerebrosidase inhibitor.		Glucokinase
T4280	Gcase activator 1	LTI-291,LTI 291,LTI291	Glucosidase
	Gcase activator 1 (LTI-291) is a glucocerebrosidase (Gcase) activator.		Glucosidase
T8990	ML266		Glucokinase
	ML266, a glucocerebrosidase (GCase) chaperone with an IC50 of 2.5 µM, facilitates the transport of the mutant protein to the lysosome, thereby restoring GCase activity without inhibiting the enzyme's function. This compo...		Glucokinase
T39518	PFB-FDGlu		Others
	PFB-FDGlu is a lysosomal Glucocerebrosidase (GCase) substrate with cell-permeable specificity that is cleaved to produce fluorescein.PFB-FDGlu is often used in conjunction with a flow cytometer to measure GCase activity ...		Others
T37440	C2 Adamantanyl Galactosylceramide (d18:1/2:0)
	C2 Adamantanyl Galactosylceramide (d18:1/2:0) (AdaGalCer) is a bioactive sphingolipid. It reduces globotriaosylceramide 3 synthesis from exogenous lactosylceramide in microsomes. AdaGalCer stimulates recombinant glucocer...
T80994	Therapeutic agent-1
	Therapeutic Agent-1, a heteroaryl compound, serves as an enzyme replacement therapy to enhance glucocerebrosidase activity in the treatment of Gaucher disease [1].
T78493	Glucosylsphingosine	Lyso-Gb1,Glucopsychosine
	Glucosylsphingosine (lyso-Gb1), a deacylated glucosylceramide derivative metabolized by glucocerebrosidase, serves as a promising, reliable, and specific biomarker for Gaucher disease monitoring [1].
T37928	13C6 Glucosylsphingosine (d18:1)
	13C6 Glucosylsphingosine (d18:1) is an isotopically enriched form of 1-β-D-glucosylsphingosine (d18:1) that is intended for use as an internal standard for the quantification of 1-β-D-glucosylsphingosine by GC- or LC-MS....
T38213	1-β-D-Glucosylsphingadienine (d18:2 (4E,8E))	1-β-D-Glucosylsphingadienine (d18:2 (4E,8E))
	1-β-D-Glucosylsphingadienine is a glucosylsphingosine, which are deacetylated lysolipid derivatives of glucosylcerebrosides . They are formed when sphingosines undergo glucosidation by UDP-glucose. Glucosylsphingosines c...