eosinophilic — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
TN2290	Uvaol		Endogenous Metabolite , JNK , PPAR
	Uvaol is present in olives and virgin olive oil with anti-inflammatory, anti-proliferative, and vasorelaxant activities.		Endogenous Metabolite , JNK , PPAR
T9962	Mepolizumab	SB 240563	IL Receptor
	Mepolizumab (SB 240563) is a humanized monoclonal antibody neutralizing IL-5. Mepolizumab can be used in studies about severe eosinophilic asthma and eosinophilic granulomatosis with polyangiitis.		IL Receptor
T4902	Isotrifoliin	Isoquercetin,Isoquercitroside	Reactive Oxygen Species
	Isotrifoliin (Isoquercitroside)n is an effective antioxidant and an eosinophilic inflammation suppressor.		Reactive Oxygen Species
T4S2164	Narirutin	Naringenin-7-O-rutinoside,Isonaringin	Others , Antibacterial
	1. Narirutin (Naringenin-7-O-rutinoside) has antiproliferative property. 2. Narirutin has anti-oxidant property. 3. Narirutin has anti-allergic and anti-inflammatory properties , can reduce airway inflammation in ovalbum...		Others , Antibacterial
T10497	Benralizumab	BIW-8405,MEDI-563	Apoptosis , IL Receptor , Interleukin
	Benralizumab (MEDI-563) is a monoclonal antibody targeting the interleukin-5 receptor alpha (IL-5Rα). It enhances antibody-dependent cell-mediated cytotoxicity, leading to a rapid depletion of eosinophils. Benralizumab i...		Apoptosis , IL Receptor , Interleukin
TP2008L	Lyn peptide inhibitor acetate	Lyn peptide inhibitor acetate(222018-18-0 free base)	IL Receptor
	Lyn peptide inhibitor acetate is a potent and cell-permeable inhibitor of Lyn-coupled IL-5 receptor signaling pathway, while keeping other signals intact. Lyn peptide inhibitor blocks Lyn activation and inhibits the bind...		IL Receptor
T8274	3-Methyl-L-histidine		Endogenous Metabolite
	3-Methylhistidine belongs to the class of organic compounds known as histidine and derivatives. Histidine and derivatives are compounds containing cysteine or a derivative thereof resulting from reaction of cysteine at t...		Endogenous Metabolite
T12706	Reslizumab	Sch 55700	IL Receptor
	Reslizumab is humanized monoclonal antibodies that target interleukin-5 (IL-5) for the treatment of eosinophilic asthma.		IL Receptor
T70107	Olcorolimus
	Olcorolimus inhibits single allergen-induced allergic inflammation such as eosinophilic and lymphocytic infiltration and mRNA expression for interleukin (IL)-4 and IL-5
T30535	BMS-639623	UNII-PON9OFP69G,PON9OFP69G,BMS 639623,CHEMBL399495
	BMS-639623 is a CCR3 antagonist with a picomolar inhibitory effect on eosinophilic chemotaxis and can be used in the treatment of asthma.
T11521	GW 766994	GW 994	CCR
	GW 766994 is a specific and oral chemokine receptor-3 (CCR3) antagonist. It has the potential for asthma and eosinophilic bronchitis treatment.		CCR
T63629	PDGFRα/FLT3-ITD-IN-2
	PDGFRα/FLT3-ITD-IN-2 is a potent inhibitor of PDGFRα (IC50>20 μM) and FLT3 (IC50: 0.004 μM). PDGFRα/FLT3-ITD-IN-2 has shown investigational potential in acute myeloid leukemia or chronic eosinophilic leukemia.
T80599	Dectrekumab	QAX576
	Dectrekumab (QAX576), a humanized monoclonal antibody targeting IL-13, significantly reduces intraepithelial esophageal eosinophil counts and normalizes dysregulated esophageal disease-related transcripts in Eosinophilic...
T63454	PDGFRα/FLT3-ITD-IN-1
	PDGFRα/FLT3-ITD-IN-1 are potent inhibitors of PDGFRα/FLT3, and their IC50 values are greater than 0.036 and 0.003 μM, respectively. PDGFRα/FLT3-ITD-IN-1 exhibits investigational potential in acute myeloid leukemia or chr...
T63127	PDGFRα/FLT3-ITD-IN-3
	PDGFRα/FLT3-ITD-IN-3 (Compound 18d) is a potent inhibitor of PDGFRα (IC50: 0.153 μM), FLT3 (IC50: 0.004 μM) and PDGFRα/FLT3-ITD-IN-3 has the potential to be studied in acute myeloid leukaemia or chronic eosinophilic leuk...
T76869	Lirentelimab
	Lirentelimab (AK002), a humanized IgG1 monoclonal antibody, specifically targets sialic acid-binding Ig-like lectin 8 (SIGLEC8). It promotes apoptosis in IL-5-activated eosinophils and suppresses IgE-mediated activation ...
TP2008	Lyn peptide inhibitor
	Cell-permeable inhibitor of Lyn-dependent effects of the IL-5 receptor. Blocks binding of Lyn tyrosine kinase to βc subunit of IL-3/GM-CSF/IL-5 receptors, blocking Lyn activation. Inhibits IL-5 receptor-mediated eosinoph...
T75806	Lyn peptide inhibitor TFA
	Lyn Peptide Inhibitor TFA is a powerful, cell-permeable inhibitor specifically targeting the Lyn-coupled IL-5 receptor signaling pathway, without affecting alternative signaling pathways. It effectively prevents Lyn acti...
T76942	Cendakimab
	Cendakimab (RPC4046; ABT 308; CC-93538) is a selective humanized recombinant monoclonal antibody targeting the IL-13 molecule with high specificity. It demonstrates potent affinity for both the wild-type and variant form...