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GW 766994
😃Good
Catalog No. T11521Cas No. 408303-43-5
Alias GW 994
GW 766994 is a specific and oral chemokine receptor-3 (CCR3) antagonist. It has the potential for asthma and eosinophilic bronchitis treatment.
GW 766994
😃Good
Catalog No. T11521Alias GW 994Cas No. 408303-43-5
GW 766994 is a specific and oral chemokine receptor-3 (CCR3) antagonist. It has the potential for asthma and eosinophilic bronchitis treatment.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $1,200 | 6-8 weeks | |
| 50 mg | $1,560 | 6-8 weeks | |
| 100 mg | $2,500 | 6-8 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | GW 766994 is a specific and oral chemokine receptor-3 (CCR3) antagonist. It has the potential for asthma and eosinophilic bronchitis treatment. |
| Targets&IC50 | CCR3:7.86 (pki) |
| In vitro | GW 766994 (10 μM) counteracts CCL11-induced CDK5 activation, CDK5 and GSK3β phosphorylations, and the heightened phosphorylation of tau in hippocampal neurons. As a specific chemokine receptor-3 (CCR3) antagonist, GW 766994 has progressed to clinical trials for the treatment of asthma and eosinophilic bronchitis. |
| Alias | GW 994 |
| Molecular Weight | 451.35 |
| Formula | C21H24Cl2N4O3 |
| Cas No. | 408303-43-5 |
| Relative Density. | 1.331 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 56 mg/mL (124.07 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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