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Narirutin

Name: Narirutin
Brand: TargetMol
SKU: T4S2164
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T4S2164Cas No. 14259-46-2

Alias Naringenin-7-O-rutinoside, Isonaringin

1. Narirutin (Naringenin-7-O-rutinoside) has antiproliferative property. 2. Narirutin has anti-oxidant property. 3. Narirutin has anti-allergic and anti-inflammatory properties , can reduce airway inflammation in ovalbumin (OVA)-sensitized / challenged NC / Nga mice , a model of allergic eosinophilic airway inflammation.

Narirutin

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Purity: 99.86%

Catalog No. T4S2164Alias Naringenin-7-O-rutinoside, IsonaringinCas No. 14259-46-2

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$30	In Stock	In Stock
5 mg	$64	In Stock	In Stock
10 mg	$113	In Stock	In Stock
25 mg	$213	In Stock	In Stock
50 mg	$319	In Stock	In Stock
100 mg	$475	-	In Stock
500 mg	$987	Inquiry	Inquiry

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.86%

Appearance:Solid

Color:White to Yellow

Resource Download

COA HNMR LCMS

Product Introduction

Narirutin AI Summary

Narirutin demonstrates a range of bioactivities, including the inhibition of procoagulant activity in human monocytes by counteracting IL1-induced tissue factor expression at 10 uM after 18 hours, showing an activity level of 0.0 microunits per 10^5 cells. It also inhibits TNFalpha expression in LPS-stimulated human monocytes, albeit with a relatively weak potency (IC50 > 200,000 nM). The compound possesses antioxidant properties, evidenced by a TEAC assay result of 0.76 trolox equivalent units (MU). In enzymatic assays, Narirutin inhibits electric eel AChE by 22.1% at a concentration of 2 mg/ml, but shows negligible inhibition on horse BChE (-0.5%). It also inhibits PTP1B with an IC50 of 56500.0 nM and exhibits anti-diabetic activity in insulin-resistant human HepG2 cells with an effectiveness of 86.93% in enhancing insulin-stimulated glucose uptake. However, its inhibition of alpha-glucosidase is weak (IC50 > 200,000 nM). Remarkably, Narirutin inhibits self-induced amyloid beta aggregation by 53.0% at 20 uM and human BACE-1 by 79.3% at 500 uM, indicating potential therapeutic value for conditions related to amyloid aggregation..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	1. Narirutin (Naringenin-7-O-rutinoside) has antiproliferative property. 2. Narirutin has anti-oxidant property. 3. Narirutin has anti-allergic and anti-inflammatory properties , can reduce airway inflammation in ovalbumin (OVA)-sensitized / challenged NC / Nga mice , a model of allergic eosinophilic airway inflammation.
Synonyms	Naringenin-7-O-rutinoside, Isonaringin

Chemical Properties

Molecular Weight	580.53
Formula	C₂₇H₃₂O₁₄
Cas No.	14259-46-2
Smiles	C[C@@H]1O[C@@H](OC[C@H]2O[C@@H](Oc3cc(O)c4C(=O)C[C@H](Oc4c3)c3ccc(O)cc3)[C@H](O)[C@@H](O)[C@@H]2O)[C@H](O)[C@H](O)[C@H]1O
Relative Density.	1.66 g/cm3 (Predicted)

Storage & Solubility Information

Storage

keep away from direct sunlight | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Pyridine, Methanol, etc.: Soluble

Ethanol: Soluble

DMSO: 237.5 mg/mL (409.11 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (5.68 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7226 mL	8.6128 mL	17.2256 mL	86.1282 mL
5 mM	0.3445 mL	1.7226 mL	3.4451 mL	17.2256 mL
10 mM	0.1723 mL	0.8613 mL	1.7226 mL	8.6128 mL
20 mM	0.0861 mL	0.4306 mL	0.8613 mL	4.3064 mL
50 mM	0.0345 mL	0.1723 mL	0.3445 mL	1.7226 mL
100 mM	0.0172 mL	0.0861 mL	0.1723 mL	0.8613 mL

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc