enzyme — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T11940	Malic enzyme inhibitor ME1	ME1	Others
	Malic enzyme inhibitor ME1 (ME1) is a specific inhibitor of Malic enzyme (IC50 = 0.15 μM). Malic enzyme inhibitor ME1 reduces cell viability/metabolic activity.		Others
T76169	Angiotensin-converting enzyme
	Angiotensin-converting enzyme (ACE), a dicarboxypeptidase, converts inactive Angiotensin I (Ang I) to its active form, Angiotensin II (Ang II), and degrades active bradykinin (BK), functioning as a potent vasoconstrictor...
T79450	Enzyme-IN-2
	Enzyme-IN-2 (compound 15) serves as a potent urease inhibitor, exhibiting anti-ureolytic activity with a K i of 2.36 µM and an IC 50 of 0.75 µM [1].
T74878	Enzyme-IN-1
	Enzyme-IN-1 (compound 1), a peptide-based inhibitor of N-terminal nucleophile (Ntn) hydrolases, specifically targets and inhibits the chymotrypsin-like activity (CT-L) of the 20S proteasome. This compound may possess pot...
T24136	Heclin		E1/E2/E3 Enzyme
	Heclin is an inhibitor of HECT E3 ubiquitin ligase that acts by inhibiting Smurf2, Nedd4, and WWP1 with IC50 values of 6.8, 6.3, and 6.9 μM, respectively.		E1/E2/E3 Enzyme
T5374	NAcM-OPT		E1/E2/E3 Enzyme , NEDD8
	NAcM-OPT is a specific, reversible inhibitor targeting N-Acetyl-UBE2M interaction with DCN1 （IC50: 79 nM).		E1/E2/E3 Enzyme , NEDD8
T5199	COH000		E1/E2/E3 Enzyme
	COH000 is a covalent and irreversible inhibitor of small ubiquitin-like modifier (SUMO)-activating enzyme and inhibited SUMOylation (IC50: ~ 0.2 μM in vitro).		E1/E2/E3 Enzyme
T16699	PYZD-4409		Others , E1/E2/E3 Enzyme
	PYZD-4409 is a selective UBA1 inhibitor with an IC50 of 20 μM. PYZD-4409 induces cell death in malignant cells and is preferentially cytotoxic to malignant cells over normal hematopoietic cells.		Others , E1/E2/E3 Enzyme
T16102	ML-792		E1/E2/E3 Enzyme
	ML-792 is a specific small ubiquitin-like modifier (SUMO)-activating enzyme (SAE) inhibitor. Compared with NAE/NEDD8 and UAE/ubiquitin (IC50s of 32 μM and >100 μM, respectively), ML-792 is an effective and selective inhi...		E1/E2/E3 Enzyme
T16901	SMIP004		Apoptosis , Others , E1/E2/E3 Enzyme
	SMIP004 is an SKP2 E3 ligase inhibitor. SMIP004 is a cancer cell-selective apoptosis inducer of human prostate cancer cells.		Apoptosis , Others , E1/E2/E3 Enzyme
T6629	PYR-41	PYR41,PYR 41	Apoptosis , E1/E2/E3 Enzyme
	PYR-41 is the first cell-permeable inhibitor of ubiquitin-activating enzyme E1, with no activity at E2.		Apoptosis , E1/E2/E3 Enzyme
T7379	2-D08		E1/E2/E3 Enzyme , TAM Receptor
	2-D08 is a synthetic flavone that inhibits sumoylation, also inhibits Axl with an IC50 of 0.49 nM.2-D08 showed anti-aggregatory and neuroprotective effect.		E1/E2/E3 Enzyme , TAM Receptor
T12261	NSC232003		E1/E2/E3 Enzyme
	NSC232003 is a highly potent and cell-permeable inhibitor of UHRF1.		E1/E2/E3 Enzyme
T9236	WSB1 Degrader 1		Others , E1/E2/E3 Enzyme
	WSB1 Degrader 1 is a potent, orally active degrader of WD repeat and SOCS box-containing 1, exhibiting anti-cancer metastatic effects.		Others , E1/E2/E3 Enzyme
T7415	DKM 2-93		E1/E2/E3 Enzyme
	DKM 2-93 is a relatively selective inhibitor of UBA5(IC50 : 430 μM).		E1/E2/E3 Enzyme
T3517	RO8994		Mdm2 , E1/E2/E3 Enzyme , p53
	RO8994 is a highly effective and specific inhibitor of spiroindolinone small-molecule MDM2, with IC50 of 20 nM (MTT proliferation assays) and 5 nM (HTRF binding assays).		Mdm2 , E1/E2/E3 Enzyme , p53
T3317	SZL P1-41		Apoptosis , Others , E1/E2/E3 Enzyme
	SZL P1-41, a skp2 inhibitor, can prevent assembly of Skp2-Skp1 complexes. It selectively suppresses Skp2 SCF E3 ligase activity but exhibits no effect on the activity of other SCF complexes. It also inhibits Skp2-mediate...		Apoptosis , Others , E1/E2/E3 Enzyme
T2158	Nutlin-3	Nutlin3	E1/E2/E3 Enzyme
	Nutlin-3 is an MDM2 antagonist.Nutlin-3 inhibits the MDM2-p53 interaction (IC50: 0.09 μM) and activates p53. Antiproliferative agent; chemotherapeutic agent; induces apoptosis in Y cells.		E1/E2/E3 Enzyme
T8428	Subasumstat	TAK-981	E1/E2/E3 Enzyme
	Subasumstat (TAK-981) is a selective the SUMOylation enzymatic cascade inhibitor, has potential immune-activating and antineoplastic activities.		E1/E2/E3 Enzyme
T11980	MD-224		Mdm2 , E1/E2/E3 Enzyme , PROTACs
	MD-224 is a highly potent and efficacious MDM2 degrader based on the proteolysistargeting chimera (PROTAC) concept,and as a new class of anticancer agent.		Mdm2 , E1/E2/E3 Enzyme , PROTACs