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Malic enzyme inhibitor ME1

Catalog No. T11940 CAS 522649-59-8

Synonyms: ME1

Malic enzyme inhibitor ME1 (ME1) is a specific inhibitor of Malic enzyme (IC50 = 0.15 μM). Malic enzyme inhibitor ME1 reduces cell viability/metabolic activity.

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Malic enzyme inhibitor ME1 Chemical Structure

Malic enzyme inhibitor ME1, CAS 522649-59-8

Pack Size	Availability	Price/USD
1 mg	In stock	$ 67.00
5 mg	In stock	$ 198.00
10 mg	In stock	$ 363.00
25 mg	In stock	$ 616.00
50 mg	In stock	$ 877.00
100 mg	In stock	$ 1,180.00
500 mg	In stock	$ 2,390.00
1 mL * 10 mM (in DMSO)	In stock	$ 159.00

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Purity: 99.93%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Malic enzyme inhibitor ME1 (ME1) is a specific inhibitor of Malic enzyme (IC50 = 0.15 μM). Malic enzyme inhibitor ME1 reduces cell viability/metabolic activity.
Targets&IC50	Malic enzyme:0.15 μM
In vitro	In HCT116 cells and HT29 cells, Malic enzyme inhibitor ME1 (50 μM) significantly reduces the total number of cells and cell colonies in a dose-dependent manner. In MTS cells, Malic enzyme inhibitor ME1 decreases the viability and metabolic activities of cells[2].

Synonyms	ME1
Molecular Weight	351.4
Formula	C20H21N3O3
CAS No.	522649-59-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 90.0 mg/mL (256.1 mM), Sonication and heating to 60℃ are recommended.

References and Literature

1. Zhang YJ, et al. In silico design and synthesis of piperazine-1-pyrrolidine-2,5-dione scaffold-based novel malic enzyme inhibitors. Bioorg Med Chem Lett. 2006 Feb;16(3):525-8. Epub 2005 Nov 8. 2. Fernandes L, et al. Malic Enzyme 1 (ME1) is pro-oncogenic in ApcMin/+ mice. Sci Rep. 2018 Sep 24;8(1):14268.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Bioactive Compound Library Bioactive Compounds Library Max

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Malic enzyme inhibitor ME1 522649-59-8 Others ME 1 ME1 ME-1 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.