endocytosis — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T26357	Pitstop 2		Apoptosis
	Pitstop2 is a selective inhibitor of amphiphysin association of clathrin terminal domain with an IC50 value of 12 μM. Pitstop2 acutely interferes with receptor-mediated endocytosis, entry of HIV, and synaptic vesicle rec...		Apoptosis
T9063	Clathrin-IN-1		HIV Protease
	Clathrin-IN-1 is a inhibitor of clathrin, and inhibits clathrin-mediated endocytosis (CME) by associating with the terminal domain of clathrin. It has the potential for anti-cancer research.		HIV Protease
T6822	Hydroxy-Dynasore	Dyngo-4a	Dynamin
	Hydroxy-Dynasore (Dyngo-4a) , a effective dynamin inhibitor, inhibits withDynI (brain), DynI (rec), and DynII (rec) of IC50 of 0.38 μM, 1.1 μM, and 2.3 μM, respectively.		Dynamin
TP1907L1	Dynamin inhibitory peptide, myristoylated acetate	Dynamin inhibitory peptide, myristoylated acetate(251634-22-7 free base)	Dynamin
	Dynamin inhibitory peptide, myristoylated acetate is a DynaMin inhibitor to interfere with the binding of amphiphysin with dynamin. DynaMin inhibitory peptide, myristoylated TFA is a membrane-permeant form of the peptide...		Dynamin
T64368	ES9-17		Others
	ES9-17, an analog of ES9 (endosidin9), is an inhibitor of clathrin-mediated endocytosis (CME). ES9-17 inhibits the uptake of FM4-64 and transferrin. ES9-17 inhibits root growth of Arabidopsis seedings.		Others
T64369	Dynamin IN-2		Dynamin
	Dynamin IN-2 (compound 43) is a Wiskostatin analogue. Dynamin IN-2 is a potent dynamin inhibitor (dynamin I GTPase, IC50= 1.0 μM). Dynamin IN-2 blocks clathrin mediated endocytosis (CME) (IC50= 9.5 μM).		Dynamin
T67931	[Tyr3]Octreotate		Others
	[Tyr3]Octreotate is a long peptide compound containing 8 amino acids and is a functional DOTA chelating agent with covalent bonds. [Tyr3]Octreotate binds to transmembrane receptors of SSR2-active NETs and is actively tra...		Others
T35856	BMS-986176		AAK1 (AP2 associated kinase 1)
	AAK1-IN-1 (example 123) is an AAK1 (adaptor associated kinase 1) inhibitor with an IC50 of 2.2 nM. AAK1-IN-1 can be used for neurodegenerative diseases research[1]. Adaptor associated kinase 1 (AAK1) is a member of the A...		AAK1 (AP2 associated kinase 1)
T15556	Ikarugamycin		Others
	Ikarugamycin, an antibiotic, is an inhibitor of clathrin-mediated endocytosis (CME).		Others
T36368	2H-Cho-Arg (trifluoroacetate salt)
	2H-Cho-Arg is a steroid-based cationic lipid that contains a 2H-cholesterol skeleton coupled to an L-arginine head group and can be used to facilitate gene transfection. It forms a complex with plasmid DNA (pDNA) and dec...
T38617	Biotin-TAT (47-57)
	Biotin-TAT (47-57) is a biotin-tagged transactivator of transcription, commonly employed as a protein transduction domain (PTD) in various primary cells. Its transduction capacity is contingent on ATP and temperature, su...
TP1907	DynaMin inhibitory peptide, myristoylated
	Cell-permeable version of dynamin inhibitory peptide, an inhibitor of the GTPase dynamin that competitively blocks binding of dynamin to amphiphysin, preventing endocytosis. Reduces NMDA receptor internalization.
T61488	Dynole 2-24
	Dynole 2 24 is an indole-based dynamin GTPase inhibitor ( IC 50 =0.56 μM for dynamin I). Dynole 2 24 is nontoxic and shows increased potency against dynamin I and II in vitro and in cells (IC (CME) =1.9 μM). Dynole 2 2...
T36350	Cho-Arg (trifluoroacetate salt)
	Cho-Arg is a steroid-based cationic lipid that contains a cholesterol skeleton coupled to an L-arginine head group. It forms a complex with plasmid DNA and decreases plasmid DNA migration in an agarose-gel retardant assa...
TP2039	Dynamin inhibitory peptide, myristoylated (control)
	Control peptide version of dynamin inhibitory peptide, myristoylated, an inhibitor of the GTPase dynamin that competitively blocks binding of dynamin to amphiphysin, preventing endocytosis. In contrast to dynamin inhibit...
T38407	RTIL 13
	RTIL 13 is a highly effective inhibitor of dynamin GTPase, exhibiting an IC50 value of 2.3 μM for dynamin I GTPase. Furthermore, it selectively interacts with the pleckstrin homology lipid binding domain. This compound e...
T79105	BVFP		Neurotensin Receptor
	BVFP exhibits affinity for the PGRN 588–593 peptide through binding with a dissociation constant (Kd) of 20 μM and is capable of disrupting the interaction between PGRN and SORT1. Moreover, BVFP inhibits the SORT1-mediat...		Neurotensin Receptor
T80140	(Val3,Pro8)-Oxytocin		Oxytocin Receptor
	(Val3,Pro8)-Oxytocin functions primarily as a Gq-dependent pathway agonist and exhibits secondary activity as a reduced efficacy agonist for β-arrestin recruitment and receptor-mediated endocytosis at the oxytocin recept...		Oxytocin Receptor
T36359	Dios-Arg (trifluoroacetate salt)
	Dios-Arg is a steroid-based cationic lipid that contains a diosgenin skeleton coupled to an L-arginine head group. It forms a complex with plasmid DNA and decreases plasmid DNA migration in an agarose-gel retardant assay...
T75796	Dynamin inhibitory peptide TFA
	Dynamin Inhibitory Peptide TFA competitively inhibits the binding of dynamin to amphiphysin, effectively preventing endocytosis. Additionally, this compound impedes the dopamine D3's influence on GABA A receptors [1].