disruptor — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T0787	Butylhydroxyanisole	BHA,E320,Butylated hydroxyanisole	Antioxidant , Ferroptosis , Reactive Oxygen Species
	Butylhydroxyanisole (BHA) is an antioxidant consisting of a mixture of two isomeric organic compounds, 2-tert-butyl-4-hydroxyanisole and 3-tert-butyl-4-hydroxyanisole.		Antioxidant , Ferroptosis , Reactive Oxygen Species
TQ0055	AMG-3969		Glucokinase
	AMG-3969 is an effective glucokinase-glucokinase regulatory protein interaction (GK-GKRP) disruptor (IC50: 4 nM).		Glucokinase
T13807	OSIP-486823	CP248	Microtubule Associated , PKA
	OSIP-486823（CP248） is a novel and potent microtubule disruptor with affinity for both protein kinase G (PKG) and microtubules.		Microtubule Associated , PKA
T72049	4-N-Nonyloxyphenol	4-nonoxyphenol,p-Nonyloxyphenol
	4-N-Nonyloxyphenol (4-nonoxyphenol), a heterogeneous photosensitizer based on kaolinite nanotubes, is a widely used pesticide and endocrine disruptor for the photodegradation of phenol-based pesticides.
T5626	Atrazine	Aktikon,Chromozin,Gesaprim,Oleogesaprim	Others
	Atrazine (Oleogesaprim) is an herbicide that does not occur naturally,and is a selective triazine herbicide. Atrazine (Oleogesaprim) is also a potent endocrine disruptor.		Others
T9093	NY2267	Acetic acid, 2-[[6-[2-(cyclohexylamino)-1-[[(4-methoxyphenyl)methyl](2-pyridinylcarbonyl)amino]-2-oxoethyl]-2-naphthalenyl]oxy]-, 1,1-dimethylethyl ester	c-Myc
	NY2267 (Acetic acid, 2-[[6-[2-(cyclohexylamino)-1-[[(4-methoxyphenyl)methyl](2-pyridinylcarbonyl)amino]-2-oxoethyl]-2-naphthalenyl]oxy]-, 1,1-dimethylethyl ester) is a disruptor of Myc-Max interaction, with an IC50 of 36...		c-Myc
T2060	ELR510444	LR-510444,LR510444,LR 510444	Apoptosis , Microtubule Associated
	ELR510444 (LR510444) is a novel microtubule disruptor; inhibits MDA-MB-231 cell proliferation with IC50 of 30.9 nM; not a substrate for the P-glycoprotein drug transporter and retains activity in βIII-tubulin-overexpress...		Apoptosis , Microtubule Associated
T9118	KEA1-97		Apoptosis , Others , Caspase
	Kea1-97 is a selective disruptor of interaction between thioredoxin and caspase-3 (IC50 = 10 μ M). Kea1-97 destroys the interaction between thioredoxin and caspase 3 and activates caspases without affecting the activity ...		Apoptosis , Others , Caspase
T5623	Bisphenol A		Others , Endogenous Metabolite
	Bisphenol A is an endogenous metabolic compound of phenols and is widely used in the production of epoxy resins and polycarbonate plastics. It is reproductive, developmental and systemic toxicant and is often classified ...		Others , Endogenous Metabolite
T14212	AMG-1694		Glucokinase
	AMG-1694, a potent disruptor of the glucokinase–glucokinase regulatory protein (GK-GKRP) complex, operates by promoting the dissociation of this complex, thereby indirectly enhancing GK enzymatic activity with an IC50 of...		Glucokinase
T13725	Hsp90-Cdc37-IN-1		Others
	Hsp90-Cdc37-IN-1 is an Hsp90-Cdc37 interaction disruptor (IC50: 140 nM) that inhibit cell migration and reverse drug resistance.		Others
T20273	Diamyl phthalate	NSC 4720,NSC-4720,NSC4720
	Diamyl phthalate is an agent of endocrine disruptor.
T34858	THIQ-20c	THIQ 20c
	THIQ-20c is a steroidomimetic and chimeric microtubule disruptor.
T34711	STAD 2	STAD-2,STAD2
	STAD-2 is a cell permeable akap disruptor, selectively binding to pka-rii and blocking the interaction of pka-ri with akap
T68528	M-COPA
	M-COPA is a golgi disruptor which inhibits cell surface expression of MET protein and the ADP-ribosylation factor 1 (Arf1) activation. M-COPA also inhibits angiogenesis through suppression of both VEGFR1/2 and nuclear fa...
T38379	4-tert-Octylphenol diethoxylate
	4-tert-Octylphenol diethoxylate is a degradation product of the multi-purpose surfactant, Triton X. A known environmental contaminant, 4-tert-octylphenol diethoxylate is reported to be an endocrine disruptor in animal an...
TP2129	RI-STAD 2
	AKAP disruptor. Selectively binds PKA-RI with high affinity (KD values are 6.2 and 12.1 nM for the RIα and β subunits, respectively) and blocks its interaction with AKAP. Inhibits type I PKA-mediated phosphorylation in l...
T60539	KG-548
	KG-548 is an ARNT/TACC3 disruptor as well as a HIF-1α inhibitor. KG-548 directly interferes with the formation of the ARNT/TACC3 complex by competitively binding the ARNT PAS-B domain with TACC3. ARNT is the aryl hydroca...
T62383	Anti-MRSA agent 2
	Anti-MRSA agent 2 (compound 14) is a good inhibitor of methicillin-resistant Staphylococcus aureus (MRSA) (MIC: 0.098 μg/ml) with relatively low toxicity to normal cells. anti-MRSA agent 2 is a strong disruptor of bacter...
T36703	CAY10760
	CAY10760 is an inhibitor of the protein-protein interaction between RAD51 recombinase and BRCA2 (EC50= 19 μM in a cell-free competitive ELISA).1It decreases homologous recombination by 54% in wild-typeBRCA2-expressing Bx...