cathepsin-d — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T37504L	Cathepsin D and E FRET Substrate acetate(839730-93-7 Free base)	Cathepsin D and E FRET Substrate acetate(839730-93-7 Free base)
	Cathepsin D and E FRET Substrate acetate is a fluorogenic substrate for cathepsins D and E but not for B, H, or L. Cathepsin D and E FRET Substrate acetate can be used in mechanistic studies on cathepsins D and E studies...
T38254	Cathepsin D and E FRET Substrate acetate
	Cathepsin D and E FRET Substrate acetate is a fluorogenic substrate selectively cleaved by cathepsins D and E at the Phe-Phe amide bond, without activity towards cathepsins B, H, or L. This specificity makes it an essent...
T37504	Cathepsin D and E FRET Substrate
	Mca-GKPILFFRL-Dpa-r-amide, FRET substrate for cathepsin D and E. Also cleaved by napsin A.
T16777	ROC-325		Apoptosis , Autophagy
	ROC-325 is an effective and orally active inhibitor of autophagy with anticancer activity. ROC-325 induces renal cell carcinoma apoptosis and exhibits favorable selectivity.		Apoptosis , Autophagy
T8709	Nandrolone phenylpropionate	Nandrolone phenpropionate	Androgen Receptor
	Nandrolone phenylpropionate (Nandrolone phenpropionate) is an androgen receptor agonist. It mainly used to treat women with breast cancer and osteoporosis		Androgen Receptor
T12188	NB-360		BACE
	NB-360 is a potent and brain-penetrable inhibitor of BACE1 and BACE2 with IC50s of 5, 5, and 6 nM for mouse and human BACE1 and BACE2. NB-360 exhibits excellent selectivity over the related aspartyl proteases pepsin, cat...		BACE
T3695	Pepstatin	Pepstatin A,Pepsin Inhibitor S 735A,Ahpatinin C	Amino Acids and Derivatives , Proteasome , HIV Protease , Autophagy
	Pepstatin (Pepsin Inhibitor S 735A) is a specific aspartic proteases inhibitor produced by actinomycetes, and inhibits the aspartic proteases cathepsin D, pepsin and renin.
T2639	LY2811376		Beta Amyloid , Beta-Secretase , BACE
	LY2811376, an orally available non-peptidic β-secretase(BACE1) inhibitor (IC50: 239-249 nM), can decrease Aβ secretion (EC50: 300 nM). It has 10-fold selectivity towards BACE1 over BACE2, and more than 50-fold inhibition...		Beta Amyloid , Beta-Secretase , BACE
T27595	Imarikiren HCl	TAK-272 hydrochloride,TAK-272 HCl. Imarikiren HCl \|,TAK272,TAK 272,TAK-272
	Imarikiren is a potent, selective and orally active direct renin inhibitor. TAK-272 shows potent inhibitory activity against human renin (IC50 = 2.1 nM) in hPRA assay and excellent selectivity against other aspartic prot...
T76614	H-Pro-Thr-Glu-Phe-p-nitro-Phe-Arg-Leu-OH
	H-Pro-Thr-Glu-Phe-p-nitro-Phe-Arg-Leu-OH is a water-soluble polypeptide capable of acting as a substrate for enzymes cathepsin D, pepsin, and pepsinogen, holding potential applications in biochemical analysis [1] [2].
T37661	LY 2886721 Hydrochloride
	Potent and selective β-secretase (BACE) inhibitor (IC50 values are 10.2 and 20.3 nM for human BACE2 and BACE1, respectively). Displays >5,000-fold selectivity for BACE over other proteases including cathepsin D, pepsin a...
T83679	Parasin I (catfish) TFA
	Parasin I, a peptide fragment derived from the N-terminal region of histone H2A in catfish (P. asotus), plays a critical role in host defense. This antimicrobial peptide is produced through the action of cathepsin D on h...
T13434	β-Secretase Inhibitor IV		Others
	β-Secretase Inhibitor IV is a potent, cell-active inhibitor of BACE-1(IC50s of 15.6 and 16.3nM under BACE-1 concentrations of 2 nM and 100 pM, respectively).		Others