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Imarikiren HCl

Catalog No. T27595 CAS 1202269-24-6

Synonyms: TAK-272 hydrochloride, TAK-272 HCl. Imarikiren HCl , |TAK272, TAK 272, TAK-272

Imarikiren is a potent, selective and orally active direct renin inhibitor. TAK-272 shows potent inhibitory activity against human renin (IC50 = 2.1 nM) in hPRA assay and excellent selectivity against other aspartic proteases, such as cathepsin D (IC50 < 10 μM) and pepsin (IC50 < 10 μM). TAK-272 exhibits a dramatically improved PK profile in rats (F = 25.2%). TAK-272 (3 and 10 mg/kg, p.o.) exhibits potent and long-lasting antihypertensive efficacy in a dose-dependent manner.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Imarikiren HCl, CAS 1202269-24-6

Pack Size	Availability	Price/USD
25 mg	8-10 weeks	$ 1,970.00
50 mg	8-10 weeks	$ 2,580.00
100 mg	8-10 weeks	$ 3,400.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Imarikiren is a potent, selective and orally active direct renin inhibitor. TAK-272 shows potent inhibitory activity against human renin (IC50 = 2.1 nM) in hPRA assay and excellent selectivity against other aspartic proteases, such as cathepsin D (IC50 > 10 μM) and pepsin (IC50 > 10 μM). TAK-272 exhibits a dramatically improved PK profile in rats (F = 25.2%). TAK-272 (3 and 10 mg/kg, p.o.) exhibits potent and long-lasting antihypertensive efficacy in a dose-dependent manner.

Synonyms	TAK-272 hydrochloride, TAK-272 HCl. Imarikiren HCl , \|TAK272, TAK 272, TAK-272
Molecular Weight	536.11
Formula	C27H42ClN5O4
CAS No.	1202269-24-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Discovery of TAK-272: A Novel, Potent, and Orally Active Renin Inhibitor Yasuhiro Imaeda, Hidekazu Tokuhara, Yoshiyuki Fukase, Ray Kanagawa, Yumiko Kajimoto, Keiji Kusumoto, Mitsuyo Kondo, Gyorgy Snell, Craig A. Behnke, and Takanobu Kuroita Publication Date (Web): September 12, 2016 (Letter) DOI: 10.1021/acsmedchemlett.6b00251

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Imarikiren HCl 1202269-24-6 TAK-272 hydrochloride TAK272 Hydrochloride TAK 272 Hydrochloride TAK-272 HCl. Imarikiren HCl | TAK272 TAK 272 TAK-272 TAK-272 Hydrochloride inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.