c-fms — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T10643	c-Fms-IN-1		c-Fms
	c-Fms-IN-1 is an inhibitor of c-FMS kinase (IC50 = 0.8 nM).		c-Fms
T10775	c-Fms-IN-2		c-Fms
	c-Fms-IN-2 is an inhibitor of c-FMS kinase (IC50 = 24 nM).		c-Fms
T10649	c-Fms-IN-3		c-Fms
	c-Fms-IN-3 is a novel inhibitor of the c-FMS and can be used in studies about antirheumatic and anti-inflammatory diseases.		c-Fms
T61589	c-Fms-IN-13		c-Fms
	c-Fms-IN-13 (compound 14) is a potent FMS kinase inhibitor (IC50= 17 nM). c-Fms-IN-13 is an anti-inflammatory agent.		c-Fms
T10648	c-Fms-IN-9		c-Fms
	c-Fms-IN-9 is a c-FMS inhibitor. It inhibits unphosphorylated c-FMS kinase (uFMS) and uKIT (IC50s: <0.01 μM and 0.1-1 μM).		c-Fms
T10646	c-Fms-IN-7		Others
	c-Fms-IN-7 is a cFMS inhibitor (IC50: 18.5 nM).		Others
T10645	c-Fms-IN-6		c-Fms
	c-Fms-IN-6 is a potent inhibitor of c-FMS (IC50 ≤10 nM for unphosphorylated c-FMS) and also weakly inhibits unphosphorylated c-KIT and PDGFR (IC50: > 1 μM).		c-Fms
T10647	c-Fms-IN-8		CSF-1R
	c-Fms-IN-8 is a colony-stimulating factor-1 receptor (CSF-1R, c-FMS) Type II inhibitor (IC50: 9.1 nM). It is compound 4a in the reference.		CSF-1R
T10644	c-Fms-IN-10		Others
	c-Fms-IN-10 is the derivative of thieno [3,2-d] pyrimidine, a kinase inhibitor of FMS (Colony-stimulating factor-1 receptor, CSF-1R; IC50: 2 nM) with anti-tumor activity.		Others
T64050	c-Fms-IN-12
	c-Fms-IN-12 is an FMS kinase inhibitor that also inhibits c-KIT and induces apoptosis in A549 cells. c-Fms-IN-12 is a potential broad-spectrum anti-cancer agent that has demonstrated therapeutic effects in a variety of c...
T79815	c-Fms-IN-14		c-Fms
	c-Fms-IN-14 (Example 76) is a potent inhibitor of the c-Fms kinase with an IC50 of 4 nM, utilized in cancer and autoimmune disease research [1].		c-Fms
T13194	CSF1R-IN-2		c-Fms , c-Met/HGFR , Src
	CSF1R-IN-2 is an oral-active SRC, MET and c-FMS inhibitor (IC50s: 0.12 nM, 0.14 nM and 0.76 nM for SRC, MET and c-FMS respectively).		c-Fms , c-Met/HGFR , Src
T5586	cFMS Receptor Inhibitor II		c-Fms
	cFMS Receptor Inhibitor II is a CSF1R kinase inhibitor		c-Fms
T10652	Vimseltinib	DCC-3014	c-Fms , CSF-1R , c-Kit
	Vimseltinib (DCC-3014) is a c-FMS (CSF-IR) and c-Kit dual inhibitor (IC50s: <0.01 μM and 0.1-1 μM).		c-Fms , CSF-1R , c-Kit
T10894	CSF1R-IN-1		c-Fms
	CSF1R-IN-1 is a CSF1R inhibitor with IC50 of 0.5 nM.		c-Fms
T2115	Pexidartinib	PLX-3397	Apoptosis , c-Fms , FLT , CSF-1R , c-Kit
	Pexidartinib (PLX-3397) is a capsule formulation containing a small-molecule receptor tyrosine kinase (RTK) inhibitor of KIT, CSF1R and FLT3 with potential antineoplastic activity.		Apoptosis , c-Fms , FLT , CSF-1R , c-Kit
T14380	AZD7507		CSF-1R , HER , Sodium Channel
	AZD7507 is a CSF-1R inhibitor with an IC50 of 32 nM. AZD7507 has antitumor activity.		CSF-1R , HER , Sodium Channel
T6119	Sotuletinib	BLZ945	c-Fms , CSF-1R
	Sotuletinib (BLZ945) is an orally active, effective and specific CSF-1R inhibitor (IC50: 1 nM), >1000-fold selective against its closest receptor tyrosine kinase homologs.		c-Fms , CSF-1R
TQ0015	PRN1371		c-Fms , FGFR , CSF-1R
	PRN1371 is a specific and potent FGFR1-4 and CSF1R inhibitor (IC50s: 0.6/1.3/4.1/19.3/8.1 nM for FGFR1/2/3/4 and CSF1R).		c-Fms , FGFR , CSF-1R
T2624	OSI-930	OSI 930	Apoptosis , c-Fms , Raf , VEGFR , FLT , CSF-1R , Src , c-Kit
	OSI-930, an orally active inhibitor of c-Kit and the vascular endothelial growth factor receptor-2 (VEGFR-2), targets cancer cell proliferation and blood vessel growth (angiogenesis) in tumors.