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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T23521 | VULM 1457 | Acyltransferase | |
VULM 1457 is a potent ACAT inhibitor. VULM 1457 has remarkable hypolipidaemic activity and improves the overall myocardial ischaemia-reperfusion injury outcomes. VULM1457 significantly reduces production and secretion of... | |||
TN1474 | Caulilexin C | Others , Antifungal | |
Caulilexin C shows inhibitory activity on human Acyl CoA: cholesterol transferase I (hACATI) and on human Acyl CoA: cholesterol transferase 2 (hACAT2) at 100 mug/ml. | |||
T5215 | N-(3-Phenylpropionyl)glycine | Phenylpropionylglycine | Others |
N-(3-Phenylpropionyl)glycine (Phenylpropionylglycine) is an acyl glycine. Acyl glycines are normally minor metabolites of fatty acids. However, the excretion of certain acyl glycines is increased in several inborn errors... | |||
T22225 | 4-Methylsalicylic acid | Others | |
4-Methylsalicylic acid is used to inhibit the medium chain acyl-CoA synthetase. | |||
T5245 | N-Isovaleroylglycine | Isovaleroylglycine,N-Isovalerylglycine | Others , Endogenous Metabolite |
N-Isovaleroylglycine (Isovaleroylglycine) is an acyl glycine. Acyl glycines are normally minor metabolites of fatty acids. However, the excretion of certain acyl glycines is increased in several inborn errors of metaboli... | |||
T4734 | Suberic acid | Octanedioic acid,1,8-Octanedioic acid | Others , Endogenous Metabolite |
Suberic acid (1,8-Octanedioic acid) is present in the urine of patients with fatty acid oxidation disorders. A metabolic breakdown product derived from oleic acid. Elevated levels of this unstaruated dicarboxylic acid ar... | |||
T4681 | T863 | DGAT-3,DGAT-1 inhibitor | Acyltransferase , Transferase |
T-863(DGAT-1 inhibitor) is an orally active, selective and potent DGAT1 (Acyl-CoA:diacylglycerol acyltransferase 1) inhibitor that interacts with the acyl-CoA binding site of DGAT1, and inhibits triacylglycerol synthesis... | |||
T29457L | 5-Hydroxydecanoate sodium | Potassium Channel | |
5-Hydroxydecanoate sodium is a selective ATP-sensitive K+ (KATP) channel blocker with IC50 of about 30 μM. 5-Hydroxydecanoate sodium is a substrate for mitochondrial outer membrane acyl-CoA synthetase with antioxidant p... | |||
T5279 | Ethylmalonic acid | alpha-Carboxybutyrate,2-Ethylmalonic acid | Others , Endogenous Metabolite |
Ethylmalonic acid (alpha-Carboxybutyrate) can be found in blood, cerebrospinal fluid (CSF), and urine, as well as in human fibroblasts, prostate, and skeletal muscle tissues. Moreover, ethylmalonic acid is found to be as... | |||
T10035 | 10,12-Tricosadiynoic acid | TDA,TCDA | Acyltransferase |
10,12-Tricosadiynoic acid is a highly selective and orally active inhibitor of acyl-CoA oxidase-1 (ACOX1). It can treat the high-fat diet- or obesity-induced metabolic diseases by improving mitochondrial lipid and ROS me... | |||
T11016 | DGAT-1 inhibitor 2 | Transferase | |
DGAT-1 inhibitor 2 is an effective DGAT-1 inhibitor; anti-obesity drug. Objective: DGAT-1 acyl-CoA: diacylglycerol acyltransferase 1 (DGAT1) is one of two known DGAT enzymes that catalyze the final step of triglyceride s... | |||
T60060 | ACSS2-IN-2 | MTB-9655 | Fatty Acid Synthase |
ACSS2-IN-2 (MTB-9655) is an inhibitor of acyl-CoA synthetase short-chain family member 2 (ACSS2). ACSS2-IN-2 can inhibit ACSS2 activity with an IC50 value of 3.8 nM. ACSS2-IN-2 can be used for the research of several dis... | |||
T12425 | PF-06424439 methanesulfonate | Acyltransferase , Transferase | |
PF-06424439 methanesulfonate, an orally administered, potent, and selective imidazopyridine diacylglycerol acyltransferase 2 (DGAT2) inhibitor with an IC50 of 14 nM, demonstrates slow reversibility and time-dependent inh... | |||
T35666 | PRGL493 | Others | |
PRGL493 is an inhibitor of long-chain acyl-CoA synthetase 4 (ACSL4).1It inhibits formation of arachidonoyl-CoA (AA-CoA) from arachidonic acid in, as well as the proliferation and migration of, PC3 and MDA-MB-231 cancer c... | |||
T14523 | Beauvericin | Others , Acyltransferase | |
Beauvericin, a Fusarium mycotoxin, inhibits acyl-CoA:cholesterol acyltransferase (ACAT) in rat liver microsomal enzyme assays with an IC50 value of 3 μM. | |||
T38905 | FATP1-IN-1 | FATP1-IN-1 | Others |
FATP1-IN-1 is a potent inhibitor of fatty acid transport protein 1 (FATP1). It effectively inhibits the activity of recombinant human or mouse acyl-CoA synthetase, which is essential for the function of FATP1. The inhibi... | |||
T4867 | Erucic acid | Prifac 2990,13(Z)-Docosenoic Acid,cis-13-docosenoic acid | PI3K , Endogenous Metabolite |
Increased levels of erucic acid (22:1n9) have been found in the red blood cell membranes of autistic subjects with developmental regression (PMID: 16581239 ). Erucic acid (13(Z)-Docosenoic Acid) is broken down long-chain... | |||
T4947 | 3-Hydroxybutyric acid | Butanoic acid | Endogenous Metabolite |
3-Hydroxybutyric acid (Butanoic acid) (or beta-hydroxybutyrate) is a ketone body. Like the other ketone bodies (acetoacetate and acetone), levels of 3-hydroxybutyrate in blood and urine are raised in ketosis. In humans, ... | |||
T5267 | N-Acetyl-L-glutamic acid | Ac-L-Glu-OH,N-Acetylglutamic acid | Others , Endogenous Metabolite |
N-Acetyl-L-glutamic acid (Ac-L-Glu-OH) (NAcGlu) is an acetylated amino acid. NAcGlu is biosynthesized from glutamic acid and acetyl-CoA by the enzyme N-acetyl glutamate synthase (NAGS). NAcGlu activates carbamoyl phospha... | |||
T13262 | FCE 28654 | ||
FCE 28654 is a water-soluble acyl-CoA inhibitor. |