vedotin — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T39595	Disitamab vedotin	RC 48,RC-48,RC48	EGFR
	Disitamab vedotin (RC-48) is an antibo-active molecular conjugate (ADC) containing a monoclonal antibody against human epidermal growth factor receptor 2 (HER2) that binds to the cytotoxic agent MMAE via a degradable lin...		EGFR
T74178	Glembatumumab vedotin	CR011-vcMMAE,CR 011 ADC,CDX-011	Microtubule Associated
	Glembatumumab vedotin (CDX-011) is an antibody-activated small molecule coupling, Glembatumumab vedotin has potent anticancer effects and can be used in the study of triple negative breast cancer (TNBC).		Microtubule Associated
T76707	Brentuximab vedotin	SGN-35	Others
	Brentuximab vedotin (SGN-35) is an antibody-activated molecule coupling (ADC) targeting CD30 with antitumor activity for the study of lymphomas.		Others
T6897	Monomethyl auristatin E	Vedotin,MMAE	Apoptosis , Microtubule Associated
	Monomethyl auristatin E (MMAE) (MMAE), an antimitotic agent, inhibits cell division by blocking the polymerization of tubulin and also has inhibition of antibody-drug conjugates (ADCs) activity.		Apoptosis , Microtubule Associated
T77838	Telisotuzumab vedotin	ABBV-399
	Telisotuzumab vedotin (ABBV-399), an antibody-drug conjugate (ADCs), targets c-Met and comprises the cytotoxic agent Monomethyl Auristatin E (MMAE), the Telisotuzumab antibody, and a cleavable mc-val-cit-PABC linker. Thi...
T77823	Polatuzumab vedotin
	Polatuzumab vedotin, an antibody-drug conjugate, selectively targets CD79b with a humanized anti-CD79b IgG1 monoclonal antibody bound to monomethyl auristatin E (MMAE), a robust microtubule inhibitor. This compound shows...
T81133	Sofituzumab vedotin	DMUC5754A
	Sofituzumab vedotin (DMUC5754A) is an antibody-drug conjugate (ADC) comprising an anti-MUC16 antibody linked to monomethyl auristatin E (MMAE) via a protease-cleavable linker, utilized for cancer research [1].
T77881	Tisotumab vedotin
	Tisotumab vedotin is an antibody-drug conjugate (ADC) that specifically targets tissue factor (TF). This compound combines a fully human monoclonal antibody directed against TF (TF-011) with the cytotoxic agent Monomethy...
T77186	Zilovertamab vedotin
	Zilovertamab vedotin (VLS-101) is a novel antibody-drug conjugate consisting of the humanized monoclonal antibody zilovertamab linked to the anti-microtubule cytotoxin monomethyl auristatin E (MMAE). Upon binding to ROR1...
T78065	Enfortumab vedotin-ejfv
	Enfortumab vedotin-ejfv is an antibody-drug conjugate targeting Nectin-4, employed in the treatment of urothelial carcinoma [1].
T77439	Glembatumumab		Others
	Glembatumumab is a fully human IgG2 monoclonal antibody targeting the extracellular structural domain of GPNMB expressed in human breast cancer and melanoma.Glembatumumab is a naked antibody to Glembatumumab vedotin and ...		Others
T76864	Enapotamab		TAM Receptor
	Enapotamab is an AXL/UFO-related antibody that can be used to synthesize antibody-drug couplings (Enapotamab Vedotin).		TAM Receptor
T77405	Enfortumab		Others
	Enfortumab is a monoclonal antibody against Nectin-4.Enfortumab can be used to synthesize antibody-drug couplings (enfortumab vedotin) and can also be used in conjunction with platinum compounds to study uroepithelial ca...		Others
T77477	Polatuzumab
	Polatuzumab is a monoclonal antibody that targets CD79b and carries chemotherapeutically active molecules.Polatuzumab adheres to CD79b proteins and transports the chemotherapeutically active molecules into cells to kill ...
T5149	MC-Val-Cit-PAB		Others , AChR
	MC-Val-Cit-PAB is a cathepsin cleavable ADC linker that is used for making antibody-drug conjugate. FDA approved drugs such as brentuximab vedotin use this linker.		Others , AChR
T3503	MC-Val-Cit-PABC-PNP	Maleimidocaproyl-L-valine-L-citrulline-p-aminobenzyl alcohol p-nitrophenyl carbonate	Others , AChR
	MC-Val-Cit-PABC-PNP, also known as Mc-Val-Cit-PABC-PNP, is a cathepsin cleavable ADC peptide linker. For example, FDA approved drug, brentuximab vedotin, adopts this linker. Protein- and peptide-drug conjugates hold a pr...		Others , AChR
T76718	Brentuximab		TNF
	Brentuximab is a chimeric antibody targeting CD30 and is a naked antibody to Brentuximab vedotin.Brentuximab has antitumor activity and may be used to study relapsed or refractory Hodgkin's lymphoma.		TNF
T77159	Disitamab
	Disitamab Vedotin (RC48-0) is a humanized monoclonal antibody that targets HER2 and can be utilized in creating antibody-drug conjugates (ADCs), specifically referred to as Disitamab Vedotin [1].
T82078	Iladatuzumab	MCDS0593A
	Iladatuzumab (MCDS0593A), a humanized IgG1 monoclonal antibody targeting CD79B, serves as a precursor for the synthesis of antibody-drug conjugates (ADCs), such as Iladatuzumab vedotin (DCDS0780A), with potential applica...
T80609	Mecbotamab
	Mecbotamab vedotin (BA3011) is a humanized IgG1-κ antibody engineered to target the AXL receptor tyrosine kinase (AXL). Serving as a conditionally active biologic (CAB), mecbotamab is conjugated to monomethyl auristatin ...