tamoxifen — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T13076	Tamoxifen-d5	ICI 47699-d5,(Z)-Tamoxifen-d5,trans-Tamoxifen-d5	HSP
	Tamoxifen-d5 is a deuterium labeled Tamoxifen. Tamoxifen is a selective modulator of estrogen receptor (SERM). Tamoxifen is a potent activator of Hsp90 and enhances the Hsp90 molecular chaperone ATPase activity.		HSP
T28919	Tamoxifen analog II	Tamoxifen analog III
	Tamoxifen analog II is a potent growth inhibitor. Tamoxifen analog II displays activity against various cancer cell lines.
T22512	4’-hydroxy Tamoxifen		Others
	It is a metabolite of tamoxifen and an estrogen receptor modulator.		Others
T4420	4-Hydroxytamoxifen	ICI 79280,(Z)-4-hydroxy Tamoxifen,trans-4-Hydroxytamoxifen	Estrogen Receptor/ERR , Estrogen/progestogen Receptor
	4-Hydroxytamoxifen (ICI 79280) is the active metabolite of Tamoxifen, an estrogen receptor modulator (SERM) with selective and oral potency. 4-Hydroxytamoxifen has antitumor activity and may be used in breast cancer rese...		Estrogen Receptor/ERR , Estrogen/progestogen Receptor
T4281	Endoxifen	(E/Z)-N-desmethyl-4-hydroxy Tamoxifen,(E/Z)-Endoxifen	Estrogen Receptor/ERR , Aromatase , Estrogen/progestogen Receptor , Parasite , Drug Metabolite
	(E/Z)-Endoxifen ((E/Z)-Endoxifen) is an active metabolite of tamoxifen produced by the sequential action of cytochrome P450 (CYP) isoforms, including CYP2D6. It is a strong anti-estrogen, as it has an approximately 100-f...
T31262	Deamino-hydroxytamoxifen	Tamoxifen-ol,Tamoxifen metabolite Y
	Tamoxifen is a medication that is used to prevent breast cancer patients.
T19192	α-Hydroxytamoxifen	α-OHTAM,(E)-α-Hydroxy tamoxifen	Others
	α-Hydroxytamoxifen is a metabolite of tamoxifen. It reacts with DNA and causes the formation of DNA adducts.		Others
T8984	FLTX1		Estrogen Receptor/ERR , Estrogen/progestogen Receptor
	FLTX1 is a fluorescent derivative of Tamoxifen, designed to efficiently target and label intracellular Tamoxifen-binding sites (estrogen receptors) both under permeabilized and non-permeabilized conditions. Additionally,...		Estrogen Receptor/ERR , Estrogen/progestogen Receptor
T12148	N-Desmethyltamoxifen hydrochloride		Estrogen Receptor/ERR , Endogenous Metabolite , PKC
	N-Desmethyltamoxifen hydrochloride is the major tamoxifen metabolite in humans.		Estrogen Receptor/ERR , Endogenous Metabolite , PKC
T6743	(E/Z)-4-Hydroxytamoxifen	Afimoxifene,4-Hydroxytamoxifen	Estrogen Receptor/ERR , Estrogen/progestogen Receptor
	(E/Z)-4-Hydroxytamoxifen (Afimoxifene) is the active metabolite of tamoxifen and a selective estrogen receptor (ER) modulator that is widely used in the therapeutic and chemopreventive treatment of breast cancer.		Estrogen Receptor/ERR , Estrogen/progestogen Receptor
T12148L	N-Desmethyltamoxifen		Others
	N-Desmethyltamoxifen, the principal metabolite of tamoxifen in humans, serves as an efficacious modulator of ceramide metabolism within human AML cells by inhibiting ceramide glycosylation, hydrolysis, and sphingosine ph...		Others
T15186	(E)-4-Hydroxytamoxifen		Others
	(E)-4-Hydroxytamoxifen is a less active isomer of (Z)-4-hydroxytamoxifen and also is an estrogen receptor modulator.		Others
T2280	Endoxifen (Z-isomer)	Endoxifen Z-isomer	Estrogen Receptor/ERR , EGFR , Potassium Channel , Estrogen/progestogen Receptor , HER
	Endoxifen Z-isomer (EDX) is a key active metabolite of tamoxifen (TAM) with higher affinity and specificity to estrogen receptors that also inhibits aromatase activity.
T15249	Estrogen receptor modulator 1		Estrogen Receptor/ERR
	Estrogen receptor modulator 1 causes regression of Tamoxifen-resistant, hormone-independent xenograft tumors. Estrogen receptor modulator 1 is an orally active and selective estrogen receptor modulator (SERM) (pIC50: 0.4...		Estrogen Receptor/ERR
T6827L	Endoxifen hydrochloride
	Endoxifen hydrochloride, a principal active metabolite of Tamoxifen (TAM), exhibits heightened affinity and specificity towards the estrogen receptor and possesses aromatase inhibitory capability. It holds promise for br...
T11098	Droloxifene	3-Hydroxytamoxifen	Estrogen Receptor/ERR
	Droloxifene (3-Hydroxytamoxifen), a tamoxifen derivative, is an oral active and selective estrogen receptor modulator.Droloxifene induced p53 expression and apoptosis in McF-7 cells.Fluroxifene has anti-estrogen and anti...		Estrogen Receptor/ERR
T3855	Tracheloside		Estrogen Receptor/ERR , Phosphorylase
	Tracheloside significantly decreases the activity of alkaline phosphatase (IC50: 0.31 μg/ml), a level of inhibition comparable to that of tamoxifen (IC50: 0.43 μg/ml).		Estrogen Receptor/ERR , Phosphorylase
T35973	Cholesterol-5α,6α-epoxide	Epoxycholesterol,5α,6α-epoxy Cholestanol,NSC 18176	Others
	Cholesterol-5α,6α-epoxide (Epoxycholesterol) is the metabolite of cholesterol produced by oxidation. Cholesterol-5α,6α-epoxide induces triacylglycerol biosynthesis by binding to LXRβ following tamoxifen and PBPE applicat...		Others
T34326	Ridaifen-B	RidaifenB
	Ridaifen-B, a tamoxifen derivative, works by inducing independent autophagy of Bcl-2, without estrogen receptor involvement.
T71578	Endoxifen mesylate
	Endoxifen, also known as N-desmethyl-4-hydroxytamoxifen, is a chemical that is under development for estrogen receptor-positive breast cancer. It is also being evaluated as an antipsychotic for treatment of mania and ot...