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Cat No. | Product Name | Synonyms | Targets |
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T4283 | SRI-011381 | TGF-beta/Smad | |
SRI-011381, a new-type agonist of the TGF-beta signaling pathway, is utilized in the treatment of Alzheimer's disease. | |||
T5129 | SRI-011381 hydrochloride | SRI-011381 hydrochloride [1629138-41-5(free base)] | TGF-beta/Smad |
SRI-011381 hydrochloride, a new-type agonist of the TGF-beta signaling pathway, is utilized in the treatment of Alzheimer's disease. | |||
T61389 | TGFβ1-IN-1 | TGF-beta/Smad | |
TGFβ1-IN-1 is an orally active TGF-β1 inhibitor that inhibits the production of TGF-β1-induced fibrotic markers (α-SMA and fibronectin) and can be used for the study of cancer and autoimmune diseases. | |||
T24470 | Mitochonic Acid 35 | MA35,MA-35,MA 35,Mitochonic Acid-35 | |
Mitochonic Acid 35 is a dual TNF-α and TGF-β1 inhibitor that acts by inhibiting IκB kinase phosphorylation and Smad3 phosphorylation. | |||
T82951 | A-TGF (34-43), rat | ||
α-TGF (34-43), rat, is an active peptide utilized in immunological research [1]. | |||
T82409 | Fepixnebart | ||
Fepixnebart is a humanized IgG4κ antibody that targets TGF-alpha (TGFA). | |||
T21978 | P-nitro-Pifithrin-α | ||
p-nitro-Pifithrin-α is a cell-permeable analog of pifithrin-α, a potent p53 inhibitor. It suppresses p53-mediated TGF-β1 expression in HK-2 cells and inhibits the activation of caspase-3 by Zika virus (ZIKV) strains. Mor... | |||
T83770 | Klotho-derived Peptide 1 (56-87) (human) TFA | KP1 (56-87) | |
Klotho-derived peptide 1 (KP1) (56-87), a peptide originating from the human Klotho protein, disrupts TGF-β signaling by binding to TGF-β receptor types 1 and 2 (TGFBR1 and TGFBR2; Kds = 1.41 and 14.6 µM, respectively). ... | |||
T74996 | FXR agonist 3 | ||
FXR agonist 3, an anti-NASH (Non-Alcoholic Steatohepatitis) agent, functions by activating FXR. It demonstrates anti-fibrogenic activity by inhibiting the expression of COL1A1, TGF-β1, α-SMA, and TIMP1. Additionally, it ... | |||
T61586 | TGFβ-IN-2 | ||
TGFβ-IN-2 (Compound 9d) effectively inhibits the accumulation of total collagen induced by TGF-β in NRK-49F cells, with an IC 50 value of 4.31 μM. It also suppresses the in vitro protein expression of COL1A1, α-SMA, and ... | |||
T71884 | ß-Carboline-1-carboxylic acid | ||
β-Carboline-1-carboxylic acid is an alkaloid that has been found in P. quassioides and has diverse biological activities. It reduces LPS-induced increases in MCP-1, TNF-α, IL-6, and IL-1β levels in RAW 264.7 cells when u... |
Cat No. | Product Name | Synonyms | Targets |
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T5S0896 | Loureirin A | Akt , PI3K | |
Loureirin A has an inhibitory effect on platelet activation, perhaps through an impairment of PI3K/Akt signaling.Loureirin A negatively affects agonist-induced platelet aggregation such as collagen, collagen-related pept... |
Cat No. | Product Name | Species | Expression System |
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TMPY-03958 | TGF alpha Protein, Human, Recombinant | Human | E. coli |
The miR-137 served as a tumor suppressor in non-small cell lung cancer (NSCLC) and its suppressive effect is mediated by repressing TGFA expression. TGFA gene expression was significantly higher in tumor tissues compared... | |||
TMPK-00888 | TGF alpha Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 Cells |
Transforming growth factor-alpha (TGFA) has been proposed as a candidate gene in the etiology of nonsyndromic cleft lip with or without cleft palate (NS-CL/P) and of nonsyndromic cleft palate only (NS-CPO). Biologic supp... | |||
TMPK-00757 | TGF alpha Protein, Human, Recombinant (hFc) | Human | HEK293 Cells |
Transforming growth factor-alpha (TGFA) has been proposed as a candidate gene in the etiology of nonsyndromic cleft lip with or without cleft palate (NS-CL/P) and of nonsyndromic cleft palate only (NS-CPO). Biologic supp... | |||
TMPJ-00290 | GFR Alpha-2/GFRA2 Protein, Human, Recombinant (hFc & His) | Human | HEK293 Cells |
GDNF family receptor alpha-2 is a glycosylphosphatidylinosito l (GPI)-linked cell surface receptor. It is part of the GDNF receptor family. Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two s... | |||
TMPJ-00851 | IDE Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Insulin-Degrading Enzyme (IDE) is a secreted enzyme that belongs to the peptidase M16 family. IDE is a large zinc-binding protease and cleaves multiple short polypeptides that vary considerably in sequence. IDE plays a r... | |||
TMPJ-00968 | NAMPT Protein, Human, Recombinant (His) | Human | E. coli |
Pre-B cell colony enhancing factor (PBEF) was originally identified as a cytokine that potentiated the clonal expansion and differentiation of pre-B cells, but it is also acknowledged to be the ubiquitous intracellular e... | |||
TMPJ-00680 | ANGPTL7 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Angiopoietin-like 7 (ANGPTL7) is a secreted glycoprotein that is structurally related to the angiopoietins. Members of this protein family contain an N-terminal coiled coil domain and a C-terminal fibrinogen-like domain.... | |||
TMPY-01027 | Mast Cell Protease-1/MCPT-1 Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells |
Mast Cell Protease 1 (MMCP-1), also known as MCP-1, MCPT-1 and β-chymase, is a member of the Chymase family of chymotrypsin-like serine proteases. MCPT-1 is a 26 kDa β-chymase that is a component of mast cell granules. I... |