tead — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
TP2160L1	YAP-TEAD-IN-1 acetate	YAP-TEAD-IN-1 acetate (1659305-78-8 Free base)	YAP
	YAP-TEAD-IN-1 acetate is an effective and competitive inhibitor of YAP–TEAD interaction with an IC50 of 25 nM.		YAP
TP2160L	YAP-TEAD-IN-1 TFA		Others
	YAP-TEAD-IN-1 TFA is a competitive inhibitor of YAP–TEAD interaction (IC50: 25 nM). It shows a higher binding affinity to TEAD1 (Kd: 15 nM) than YAP (50-171) (Kd: 40 nM).		Others
TP2160	YAP-TEAD-IN-1		Others
	YAP-TEAD-IN-1 is a competitive inhibitor of YAP–TEAD interaction (IC50: 25 nM). It shows a higher binding affinity to TEAD1 (Kd: 15 nM) than YAP (50-171) (Kd: 40 nM).		Others
T83951	TM2 TEAD inhibitor
	TM2 TEAD inhibitor, a robust and reversible inhibitor of the TEA domain transcription factor, presents dual inhibitory concentrations (IC50) of 38 nM for TEAD4 auto-palmitoylation and 156 nM for TEAD2 palmitoylation. It ...
T77725	YAP-TEAD-IN-3	IAG933	YAP
	YAP-TEAD-IN-3 is an inhibitor of YAP/TAZ-TEAD interactions with an IC50 of 9 nM for Avi-human TEAD (4217-434). YAP-TEAD-IN-3 inhibits YAP reporter gene expression (IC50 = 0.048 μM) and NCI-H2052 cell proliferation (IC50 ...		YAP
T72888	YAP-TEAD-IN-2		YAP
	YAP-TEAD-IN-2 (compound 6) serves as a potent inhibitor of the YAP-TEAD protein-protein interaction (PPI), demonstrating an inhibitory concentration 50 (IC50) value of 2.7 nM [1].		YAP
T61776	TEAD-IN-2
	TEAD-IN-2 is an innovative, orally bioavailable inhibitor that targets the transcriptional enhancer associate domain (TEAD). It functions by regulating TEAD through ubiquitination and/or degradation by specific compounds...
T79687	TEAD-IN-6		YAP
	TEAD-IN-6 (Example 11-1) is a TEAD modulator that inhibits the YAP1/TAZ-TEAD interaction, and has applications in cancer research [1].		YAP
T62597	TEAD-IN-3
	TEAD-IN-3 (compound I-177) is a potent inhibitor of the TEAD transcription factor, which can be used to study proliferative diseases such as cancer.
T8421	TED-347		YAP
	TED-347 is an irreversible and covalent inhibitor of TEAD4-Yap1 protein-protein interaction(EC50 of 5.9 μM), and inhibits glioblastoma cell viability.		YAP
T9954	K-975		Others
	K-975 is a highly selective, orally active TEAD inhibitor, effectively inhibiting protein-protein interactions between TEAD and YAP1/TAZ.		Others
T9032	MGH-CP1		Others
	MGH-CP1 is a potent and selective inhibitor TEAD palmitoylation. It exhibits dose-dependent and potent inhibition of TEAD2/4 auto-palmitoylation in vitro with IC50 of 710 nM and 672 nM, respectively.		Others
T22372	MYF-01-37	1-[3-Methyl-3-[3-(trifluoromethyl)anilino]pyrrolidin-1-yl]prop-2-en-1-one	Others , YAP
	MYF-01-37 (1-[3-Methyl-3-[3-(trifluoromethyl)anilino]pyrrolidin-1-yl]prop-2-en-1-one) is a novel covalent TEAD inhibitor.		Others , YAP
T64342	DC-TEADin02		YAP
	DC-TEADin02 is an inhibitor of TEAD auto palmitoylation (IC50 = 197 nM). DC-TEADin02 can be in studies about development, regeneration, and tissue homeostasis.		YAP
T77580	IK-930	compound I-32	YAP
	IK-930 is an orally active TEAD inhibitor (EC50 < 0.1 µM) with potent potency.		YAP
T3112	Verteporfin	BPD-MA,CL 318952	Apoptosis , YAP , VDA , Autophagy
	Verteporfin (BPD-MA) is a YAP inhibitor that inhibits YAP-TEAD interactions. Verteporfin is also a photosensitizer used in photodynamic therapy. Verteporfin also induces apoptosis and inhibits autophagy.		Apoptosis , YAP , VDA , Autophagy
T60148	MSC-4106		YAP
	MSC-4106, an orally active and potent YAP/TAZ-TEAD inhibitor, disrupts TEAD1 and TEAD3 auto-palmitoylation and demonstrates significant efficacy in the NCI-H226 tumor xenograft model [1].		YAP
T35545	VT107		YAP
	VT107 is a potent pan-TEAD auto-palmitoylation inhibitor. VT-107 can be used for the research of cancer[1].		YAP
T62077	VT103	VT-103,VT 103	YAP
	VT103 is an orally active and selective inhibitor of TEAD1 protein palmitoylation and is an analog of VT101. VT103 has potential antitumor activity by inhibiting YAP/TAZ-TEAD-promoted gene transcriptionment, blocking TEA...		YAP
T69638	VT-105	VT 105	Others
	VT-105 is a potent and selective TEAD autopalmitoylation inhibitor that inhibits proliferation and tumour growth in NF2-deficient mesotheliomas.		Others