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Search Results for " staurosporine "

11

Compounds

Cat No. Product Name Synonyms Targets
T6680 Staurosporine Antibiotic AM-2282,AM-2282,CGP 41251 Apoptosis , PKA , Antibacterial , Antibiotic , Src , PKC , Antifungal
Staurosporine (AM-2282) is a protein kinase inhibitor with ATP-competitive and non-selective inhibitory activity (IC50=6/15/2/3/3000 nM) against PKC, PKA, c-Fgr, phosphorylase kinase and TAOK2. Staurosporine also induces...
T35423 7-oxo Staurosporine
7-oxo Staurosporine is an antibiotic originally isolated from S. platensis with diverse biological activites. It inhibits PKC, PKA, phosphorylase kinase, EGFR, and c-Src in vitro (IC50s = 9, 26, 5, 200, and 800 nM, respe...
T69476 5'-Hydroxy-staurosporine
5'-Hydroxy-staurosporine is an AMPK inhibitor with selective toxicity toward human colon tumor cells.
T6S1740 Nardosinone Others
1. Nardosinone has inhibitory effect on Ang II-induced hypertrophy in H9c2 cells, might be mediated by targeting PI3K/Akt and MEK/ERK signaling pathways. 2. Nardosinone could protect against the neuronal injury exposed t...
T2787 Picroside I 6'-Cinnamoylcatalpol MMP , STAT
Picroside I (6'-Cinnamoylcatalpol), a hepatoprotective agent, is reported to be antimicrobial and used against hepatitis B. It has antioxidant, and anti-inflammatory activities, it may be the valuable anti-invasive drug ...
T70683 NA 382
NA 382 is a staurosporine derivative that inhibits multidrug resistance.
T24027 EM20-25 EM2025,EM20 25
EM20-25 is a novel BCL-2 inhibitor. It also neutralizes the antiapoptotic activity of overexpressed BCL-2 toward staurosporine.
T69812 AFN941
AFN941 is a staurosporine analog, acting as a Jak3-specific inhibitor.
T15636 K-252a Antibiotic K 252a,Antibiotic SF 2370,SF2370 Others
K-252a is a staurosporine analog isolated from Nocardiopsis sp. soil fungi. K-252a inhibits protein kinase (IC50: 470 nM, 140 nM, 270 nM, and 1.7 nM for PKC, PKA, Ca2+/calmodulin-dependent kinase type II, and phosphoryla...
T15638 K-252c PKC
K-252c is a staurosporine analog isolated from Nocardiopsis sp. and is a cell-permeable PKC inhibitor (IC50: 2.45 μM). K-252c also inhibits β-lactamase, chymotrypsin, and malate dehydrogenase. K-252c causes apoptosis in ...
TN2257 Tanshinone IIB BCL , Caspase , P-gp
Co-treatment with Tanshinone IIB (TSB) significantly inhibits the DNA laddering, cytotoxicity and apoptosis of rat cortical neurons induced by staurosporine in a concentration-dependent manner; TSB also suppresses the el...
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