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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T6680 | Staurosporine | Antibiotic AM-2282,AM-2282,CGP 41251 | Apoptosis , PKA , Antibacterial , Antibiotic , Src , PKC , Antifungal |
Staurosporine (AM-2282) is a protein kinase inhibitor with ATP-competitive and non-selective inhibitory activity (IC50=6/15/2/3/3000 nM) against PKC, PKA, c-Fgr, phosphorylase kinase and TAOK2. Staurosporine also induces... | |||
T35423 | 7-oxo Staurosporine | ||
7-oxo Staurosporine is an antibiotic originally isolated from S. platensis with diverse biological activites. It inhibits PKC, PKA, phosphorylase kinase, EGFR, and c-Src in vitro (IC50s = 9, 26, 5, 200, and 800 nM, respe... | |||
T69476 | 5'-Hydroxy-staurosporine | ||
5'-Hydroxy-staurosporine is an AMPK inhibitor with selective toxicity toward human colon tumor cells. | |||
T6S1740 | Nardosinone | Others | |
1. Nardosinone has inhibitory effect on Ang II-induced hypertrophy in H9c2 cells, might be mediated by targeting PI3K/Akt and MEK/ERK signaling pathways. 2. Nardosinone could protect against the neuronal injury exposed t... | |||
T2787 | Picroside I | 6'-Cinnamoylcatalpol | MMP , STAT |
Picroside I (6'-Cinnamoylcatalpol), a hepatoprotective agent, is reported to be antimicrobial and used against hepatitis B. It has antioxidant, and anti-inflammatory activities, it may be the valuable anti-invasive drug ... | |||
T70683 | NA 382 | ||
NA 382 is a staurosporine derivative that inhibits multidrug resistance. | |||
T24027 | EM20-25 | EM2025,EM20 25 | |
EM20-25 is a novel BCL-2 inhibitor. It also neutralizes the antiapoptotic activity of overexpressed BCL-2 toward staurosporine. | |||
T69812 | AFN941 | ||
AFN941 is a staurosporine analog, acting as a Jak3-specific inhibitor. | |||
T15636 | K-252a | Antibiotic K 252a,Antibiotic SF 2370,SF2370 | Others |
K-252a is a staurosporine analog isolated from Nocardiopsis sp. soil fungi. K-252a inhibits protein kinase (IC50: 470 nM, 140 nM, 270 nM, and 1.7 nM for PKC, PKA, Ca2+/calmodulin-dependent kinase type II, and phosphoryla... | |||
T15638 | K-252c | PKC | |
K-252c is a staurosporine analog isolated from Nocardiopsis sp. and is a cell-permeable PKC inhibitor (IC50: 2.45 μM). K-252c also inhibits β-lactamase, chymotrypsin, and malate dehydrogenase. K-252c causes apoptosis in ... | |||
TN2257 | Tanshinone IIB | BCL , Caspase , P-gp | |
Co-treatment with Tanshinone IIB (TSB) significantly inhibits the DNA laddering, cytotoxicity and apoptosis of rat cortical neurons induced by staurosporine in a concentration-dependent manner; TSB also suppresses the el... |