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K-252a

Catalog No. T15636 CAS 99533-80-9

Synonyms: Antibiotic K 252a, Antibiotic SF 2370, SF2370

K-252a is a staurosporine analog isolated from Nocardiopsis sp. soil fungi. K-252a inhibits protein kinase (IC50: 470 nM, 140 nM, 270 nM, and 1.7 nM for PKC, PKA, Ca2+/calmodulin-dependent kinase type II, and phosphorylase kinase, respectively).

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K-252a, CAS 99533-80-9

Pack Size	Availability	Price/USD	Quantity
1 mg	35 days	$ 143.00
5 mg	35 days	$ 520.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	K-252a is a staurosporine analog isolated from Nocardiopsis sp. soil fungi. K-252a inhibits protein kinase (IC50: 470 nM, 140 nM, 270 nM, and 1.7 nM for PKC, PKA, Ca2+/calmodulin-dependent kinase type II, and phosphorylase kinase, respectively).
Targets&IC50	CaMK II:270 nM, PKC:470 nM, PKA:140 nM, PhK:1.7 nM
In vitro	K-252a is an effective inhibitor (IC50: 3 nM) of the tyrosine-protein kinase (TRK) activity of the NGF receptor gp140trk, the product of the trk proto-oncogene [3].

Synonyms	Antibiotic K 252a, Antibiotic SF 2370, SF2370
Molecular Weight	467.47
Formula	C27H21N3O5
CAS No.	99533-80-9

Storage

keep away from direct sunlight

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Yasuzawa, T., et al. The structures of the novel protein kinase C inhibitors K-252a, b, c AND d Journal of Antibiotics 39(8), 1072-1078 (1986). 2. Davis, P.D., et al. Inhibitors of protein kinase C. 1.1 2,3-bisarylmaleimides Journal of Medicinal Chemistry 35, 177-184 (1992). 3. Tapley P, et al. K252a is a selective inhibitor of the tyrosine protein kinase activity of the trk family of oncogenes and neurotrophin receptors. Oncogene. 1992 Feb;7(2):371-81.

Citations

1. Ge J B, Jiang B, Shi T S, et al.Cucurbitacin B exerts significant antidepressant-like effects in a chronic unpredictable mild stress model of depression: Involvement of the hippocampal BDNF-TrkB system.International Journal of Neuropsychopharmacology.2023: pyad052.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

K-252a 99533-80-9 Others Antibiotic SF2370 K 252a SF-2370 K252a Antibiotic K 252a SF 2370 Antibiotic SF 2370 SF2370 Antibiotic SF-2370 inhibitor inhibit

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